(22 nodes) Erythrocyte development network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	SRF	Serum response factor. (597 aa)
	I3JWF9_ORENI	MADS-box domain-containing protein. (506 aa)
	I3K114_ORENI	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family. (338 aa)
	sh2b3	SH2B adaptor protein 3. (723 aa)
	bdh2	3-hydroxybutyrate dehydrogenase, type 2. (245 aa)
	LOC100689943	Ribosomal protein S19. (163 aa)
	RPS19	Ribosomal protein S19. (175 aa)
	lyar	Ly1 antibody reactive. (358 aa)
	epo	Erythropoietin; Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Belongs to the EPO/TPO family. (204 aa)
	maea	Macrophage erythroblast attacher. (409 aa)
	LOC109194259	T-cell acute lymphocytic leukemia 1. (447 aa)
	ENSONIP00000035341	T-cell acute lymphocytic leukemia protein 1 homolog. (100 aa)
	LOC100696076	GATA binding protein 1a. (457 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1834 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1167 aa)
	lmo2	LIM domain only 2 (rhombotin-like 1). (161 aa)
	melk	Non-specific serine/threonine protein kinase. (701 aa)
	LOC100698203	Phospholipase A(2). (153 aa)
	LOC100697245	5-aminolevulinate synthase. (591 aa)
	slc40a1	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily. (567 aa)
	LOC112841626	Erythroid transcription factor-like isoform X1. (280 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000035341	LOC100696076	ENSONIP00000035341	ENSONIP00000038387	T-cell acute lymphocytic leukemia protein 1 homolog.	GATA binding protein 1a.	0.764
ENSONIP00000035341	LOC112841626	ENSONIP00000035341	ENSONIP00000080130	T-cell acute lymphocytic leukemia protein 1 homolog.	Erythroid transcription factor-like isoform X1.	0.764
ENSONIP00000035341	lmo2	ENSONIP00000035341	ENSONIP00000051247	T-cell acute lymphocytic leukemia protein 1 homolog.	LIM domain only 2 (rhombotin-like 1).	0.965
I3K114_ORENI	LOC100697245	ENSONIP00000014809	ENSONIP00000059787	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	5-aminolevulinate synthase.	0.581
I3K114_ORENI	slc40a1	ENSONIP00000014809	ENSONIP00000074915	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.	0.465
LOC100689943	RPS19	ENSONIP00000020360	ENSONIP00000024879	Ribosomal protein S19.	Ribosomal protein S19.	0.901
LOC100689943	lyar	ENSONIP00000020360	ENSONIP00000025664	Ribosomal protein S19.	Ly1 antibody reactive.	0.693
LOC100689943	med1	ENSONIP00000020360	ENSONIP00000038435	Ribosomal protein S19.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.952
LOC100696076	ENSONIP00000035341	ENSONIP00000038387	ENSONIP00000035341	GATA binding protein 1a.	T-cell acute lymphocytic leukemia protein 1 homolog.	0.764
LOC100696076	LOC100697245	ENSONIP00000038387	ENSONIP00000059787	GATA binding protein 1a.	5-aminolevulinate synthase.	0.465
LOC100696076	LOC109194259	ENSONIP00000038387	ENSONIP00000034543	GATA binding protein 1a.	T-cell acute lymphocytic leukemia 1.	0.764
LOC100696076	lmo2	ENSONIP00000038387	ENSONIP00000051247	GATA binding protein 1a.	LIM domain only 2 (rhombotin-like 1).	0.941
LOC100697245	I3K114_ORENI	ENSONIP00000059787	ENSONIP00000014809	5-aminolevulinate synthase.	Solute carrier family 25 member 37; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.581
LOC100697245	LOC100696076	ENSONIP00000059787	ENSONIP00000038387	5-aminolevulinate synthase.	GATA binding protein 1a.	0.465
LOC100697245	LOC112841626	ENSONIP00000059787	ENSONIP00000080130	5-aminolevulinate synthase.	Erythroid transcription factor-like isoform X1.	0.465
LOC109194259	LOC100696076	ENSONIP00000034543	ENSONIP00000038387	T-cell acute lymphocytic leukemia 1.	GATA binding protein 1a.	0.764
LOC109194259	LOC112841626	ENSONIP00000034543	ENSONIP00000080130	T-cell acute lymphocytic leukemia 1.	Erythroid transcription factor-like isoform X1.	0.764
LOC109194259	lmo2	ENSONIP00000034543	ENSONIP00000051247	T-cell acute lymphocytic leukemia 1.	LIM domain only 2 (rhombotin-like 1).	0.981
LOC112841626	ENSONIP00000035341	ENSONIP00000080130	ENSONIP00000035341	Erythroid transcription factor-like isoform X1.	T-cell acute lymphocytic leukemia protein 1 homolog.	0.764
LOC112841626	LOC100697245	ENSONIP00000080130	ENSONIP00000059787	Erythroid transcription factor-like isoform X1.	5-aminolevulinate synthase.	0.465