(98 nodes) Regulation of lymphocyte proliferation network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	arg2	Arginase. (352 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1133 aa)
	il10	Interleukin 10. (275 aa)
	I3KIB4_ORENI	CD40 molecule, TNF receptor superfamily member 5. (193 aa)
	LOC100706482	Arginase. (348 aa)
	tyrobp	TYRO protein tyrosine kinase binding protein. (111 aa)
	LOC109197370	Cytotoxic T-lymphocyte-associated protein 4. (234 aa)
	I3KMU3_ORENI	Insulin-like growth factor 1. (230 aa)
	ENSONIP00000043214	annotation not available (354 aa)
	LOC102078285	Cytokine receptor family member B16. (332 aa)
	I3KAU3_ORENI	Insulin-like growth factor 2b. (217 aa)
	LOC109194160	Protein kinase domain-containing protein. (516 aa)
	sh3rf1	SH3 domain containing ring finger 1. (887 aa)
	ENSONIP00000065081	annotation not available (253 aa)
	ENSONIP00000064693	annotation not available (392 aa)
	LOC100696446	Tyrosine-protein kinase. (634 aa)
	LOC109196543	Cytotoxic T-lymphocyte-associated protein 4. (234 aa)
	dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2047 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (570 aa)
	LOC100701554	Solute carrier family 7 member 1a. (646 aa)
	LOC100694718	E3 ubiquitin-protein ligase. (877 aa)
	LOC100704899	Interferon regulatory factor. (319 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (348 aa)
	LOC106097100	Ig-like domain-containing protein. (369 aa)
	LOC100709385	Programmed cell death 1 ligand 1. (297 aa)
	Fadd	Uncharacterized protein. (209 aa)
	ENSONIP00000073708	Tumor necrosis factor receptor superfamily member 14. (245 aa)
	rassf5	Ras association domain family member 5. (599 aa)
	LOC106097102	V-set domain-containing T-cell activation inhibitor 1. (378 aa)
	LOC100697584	Galectin. (366 aa)
	ENSONIP00000079049	annotation not available (248 aa)
	I3JNG7_ORENI	Uncharacterized protein. (258 aa)
	LOC106097098	V-set domain-containing T-cell activation inhibitor 1. (352 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (896 aa)
	LOC102082670	TNFR-Cys domain-containing protein. (245 aa)
	LOC102077908	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like. (272 aa)
	LOC100692238	Uncharacterized protein. (433 aa)
	ENSONIP00000071557	annotation not available (333 aa)
	Dhps	Deoxyhypusine synthase. (367 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (720 aa)
	LOC100694194	Receptor-interacting serine-threonine kinase 3. (506 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1331 aa)
	ENSONIP00000002713	annotation not available (760 aa)
	LOC100699896	Interleukin 12 receptor, beta 2a. (779 aa)
	sash3	SAM and SH3 domain containing 3. (398 aa)
	LOC100703882	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (232 aa)
	ENSONIP00000069313	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. (203 aa)
	AIF1	Allograft inflammatory factor 1. (155 aa)
	marchf7	Membrane-associated ring finger (C3HC4) 7. (799 aa)
	LOC100701722	Uncharacterized protein. (507 aa)
	I3J7Z3_ORENI	ZP domain-containing protein. (368 aa)
	I3J9Z2_ORENI	Glycoprotein (transmembrane) nmb. (611 aa)
	crtam	Ig-like domain-containing protein. (444 aa)
	I3JC33_ORENI	HERV-H LTR-associating 2a, tandem duplicate 2. (321 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (291 aa)
	atm	Non-specific serine/threonine protein kinase. (3095 aa)
	nck1	Cytoplasmic protein. (392 aa)
	LOC100694653	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (683 aa)
	I3JMV3_ORENI	Uncharacterized protein. (225 aa)
	ENSONIP00000010198	annotation not available (280 aa)
	I3JMV5_ORENI	Uncharacterized protein. (414 aa)
	I3JMW0_ORENI	Uncharacterized protein. (351 aa)
	LOC106096615	Uncharacterized protein. (235 aa)
	LOC100707066	Interleukin-1. (244 aa)
	card11	Caspase recruitment domain family, member 11. (1162 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (635 aa)
	I3JR76_ORENI	Uncharacterized protein. (238 aa)
	LOC100697163	E3 ubiquitin-protein ligase. (888 aa)
	tmem131l	Transmembrane 131 like. (1493 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1105 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1377 aa)
	vsir	V-set immunoregulatory receptor. (302 aa)
	glmn	Glomulin, FKBP associated protein a. (606 aa)
	syk	Tyrosine-protein kinase. (615 aa)
	il6st	Uncharacterized protein. (893 aa)
	LOC100700684	Galectin. (229 aa)
	I3K3F0_ORENI	Amine oxidase. (474 aa)
	LOC100710179	Ig-like domain-containing protein. (309 aa)
	LOC100708733	Leucine rich repeat containing 32. (656 aa)
	LOC100712573	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (637 aa)
	nck2	Cytoplasmic protein. (398 aa)
	tnfsf13b	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (261 aa)
	LOC100702318	Galectin. (324 aa)
	LOC100699900	ZP domain-containing protein. (454 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (272 aa)
	I3KH87_ORENI	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (824 aa)
	I3KJL2_ORENI	Tumor necrosis factor receptor superfamily, member 9a. (192 aa)
	LOC100706746	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (358 aa)
	LOC100695129	Uncharacterized protein. (659 aa)
	LOC102079736	Uncharacterized protein. (966 aa)
	LOC100707936	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (211 aa)
	LOC100706816	Galectin-3 isoform X2. (376 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (538 aa)
	Sos1	Son of sevenless homolog 1 (Drosophila). (1401 aa)
	I3KV79_ORENI	C-type lectin domain-containing protein. (367 aa)
	cd276	CD276 molecule. (306 aa)
	tnfrsf13b	Tumor necrosis factor receptor superfamily member 13B isoform X1. (247 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	LOC100707066	ENSONIP00000003539	ENSONIP00000010489	Allograft inflammatory factor 1.	Interleukin-1.	0.609
AIF1	il10	ENSONIP00000003539	ENSONIP00000038761	Allograft inflammatory factor 1.	Interleukin 10.	0.521
AIF1	ptprc	ENSONIP00000003539	ENSONIP00000012723	Allograft inflammatory factor 1.	Protein tyrosine phosphatase receptor type C.	0.503
AIF1	tyrobp	ENSONIP00000003539	ENSONIP00000041497	Allograft inflammatory factor 1.	TYRO protein tyrosine kinase binding protein.	0.893
Dhps	LOC100706482	ENSONIP00000070653	ENSONIP00000040849	Deoxyhypusine synthase.	Arginase.	0.525
Dhps	arg2	ENSONIP00000070653	ENSONIP00000032620	Deoxyhypusine synthase.	Arginase.	0.525
ENSONIP00000002713	atm	ENSONIP00000002713	ENSONIP00000006906	annotation not available	Non-specific serine/threonine protein kinase.	0.577
ENSONIP00000069313	I3KIB4_ORENI	ENSONIP00000069313	ENSONIP00000039757	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1.	CD40 molecule, TNF receptor superfamily member 5.	0.489
ENSONIP00000069313	LOC100703882	ENSONIP00000069313	ENSONIP00000003367	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.515
ENSONIP00000069313	LOC102077908	ENSONIP00000069313	ENSONIP00000044169	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1.	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like.	0.914
ENSONIP00000069313	ptprc	ENSONIP00000069313	ENSONIP00000012723	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1.	Protein tyrosine phosphatase receptor type C.	0.410
ENSONIP00000073708	LOC100703882	ENSONIP00000073708	ENSONIP00000003367	Tumor necrosis factor receptor superfamily member 14.	Tumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family.	0.695
ENSONIP00000079049	LOC109196543	ENSONIP00000079049	ENSONIP00000059827	annotation not available	Cytotoxic T-lymphocyte-associated protein 4.	0.463
ENSONIP00000079049	LOC109197370	ENSONIP00000079049	ENSONIP00000042204	annotation not available	Cytotoxic T-lymphocyte-associated protein 4.	0.464
Fadd	I3KIB4_ORENI	ENSONIP00000071989	ENSONIP00000039757	Uncharacterized protein.	CD40 molecule, TNF receptor superfamily member 5.	0.603
Fadd	LOC100694194	ENSONIP00000071989	ENSONIP00000000393	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 3.	0.975
Fadd	LOC100696446	ENSONIP00000071989	ENSONIP00000062031	Uncharacterized protein.	Tyrosine-protein kinase.	0.602
Fadd	LOC109194160	ENSONIP00000071989	ENSONIP00000066584	Uncharacterized protein.	Protein kinase domain-containing protein.	0.974
Fadd	ripk2	ENSONIP00000071989	ENSONIP00000057830	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.724
Fadd	syk	ENSONIP00000071989	ENSONIP00000014124	Uncharacterized protein.	Tyrosine-protein kinase.	0.601