STRINGSTRING
LOC100712331 LOC100712331 LOC100693895 LOC100693895 fgf1 fgf1 ENSONIP00000077461 ENSONIP00000077461 LOC100692440 LOC100692440 ENSONIP00000077507 ENSONIP00000077507 bmp4 bmp4 fgf2 fgf2 LOC100534578 LOC100534578 rptor rptor LOC100700935 LOC100700935 Vegfb Vegfb LOC100694986 LOC100694986 hlx hlx LOC100701202 LOC100701202 hpn hpn I3KXK7_ORENI I3KXK7_ORENI LOC100707172 LOC100707172 F3 F3 ENSONIP00000012226 ENSONIP00000012226 sirt1 sirt1 Xbp1 Xbp1 LOC100703394 LOC100703394 LOC100694613 LOC100694613 wnt2b wnt2b st8sia1 st8sia1 smo smo fgf7 fgf7 rreb1 rreb1 bad bad pdx1 pdx1 I3KBE6_ORENI I3KBE6_ORENI Nf1 Nf1 I3KGK9_ORENI I3KGK9_ORENI LOC100709933 LOC100709933 ara ara nkx2-5 nkx2-5 LOC100693787 LOC100693787 grn grn stxbp4 stxbp4 aggf1 aggf1 vegfc vegfc I3KWA4_ORENI I3KWA4_ORENI GAS1 GAS1 ENSONIP00000025853 ENSONIP00000025853 LOC100702089 LOC100702089 I3KYD0_ORENI I3KYD0_ORENI LOC100692879 LOC100692879 mydgf mydgf LOC106096946 LOC106096946 LOC100707786 LOC100707786 LOC100697209 LOC100697209 Prok1 Prok1 LOC100701144 LOC100701144 LOC100693354 LOC100693354 tgfa tgfa I3K4Y1_ORENI I3K4Y1_ORENI LOC100692931 LOC100692931 ENSONIP00000035199 ENSONIP00000035199 Vegfa Vegfa med1 med1 il10 il10 map2k5 map2k5 I3K981_ORENI I3K981_ORENI sirt6 sirt6 Bmpr2 Bmpr2 I3KMU3_ORENI I3KMU3_ORENI htr2b htr2b LOC100705021 LOC100705021 ENSONIP00000054096 ENSONIP00000054096 LOC100693478 LOC100693478 I3JF61_ORENI I3JF61_ORENI granulin granulin agtr1 agtr1 sp1 sp1 I3KAU3_ORENI I3KAU3_ORENI id1 id1 tnfaip3 tnfaip3 ENSONIP00000071122 ENSONIP00000071122
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100712331Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (545 aa)
LOC100693895Epithelial mitogen homolog (mouse). (164 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (182 aa)
ENSONIP00000077461Androgen receptor-like. (186 aa)
LOC100692440ADAM metallopeptidase domain 17b. (876 aa)
ENSONIP00000077507annotation not available (47 aa)
bmp4Bone morphogenetic protein 4. (403 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC100534578Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
rptorRegulatory associated protein of MTOR, complex 1. (1386 aa)
LOC100700935ADAM metallopeptidase domain 17a. (851 aa)
VegfbPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (274 aa)
LOC100694986Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1210 aa)
hlxH2.0-like homeo box 1 (Drosophila). (379 aa)
LOC100701202Uncharacterized protein. (441 aa)
hpnHepsin; Belongs to the peptidase S1 family. (427 aa)
I3KXK7_ORENIRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (134 aa)
LOC100707172Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (612 aa)
F3Coagulation factor IIIa. (298 aa)
ENSONIP00000012226Granulin a. (1456 aa)
sirt1Deacetylase sirtuin-type domain-containing protein. (712 aa)
Xbp1X-box binding protein 1. (260 aa)
LOC100703394Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
LOC100694613C2H2-type domain-containing protein. (598 aa)
wnt2bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (410 aa)
st8sia1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (335 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
rreb1Ras responsive element binding protein 1a. (1889 aa)
badBCL2 associated agonist of cell death b. (158 aa)
pdx1Pancreatic and duodenal homeobox 1. (255 aa)
I3KBE6_ORENIUncharacterized protein. (612 aa)
Nf1Neurofibromin 1b. (2742 aa)
I3KGK9_ORENIRNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (138 aa)
LOC100709933Uncharacterized protein. (277 aa)
araUncharacterized protein. (714 aa)
nkx2-5NK2 homeobox 5. (319 aa)
LOC100693787Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
grnGranulin b. (827 aa)
stxbp4Syntaxin binding protein 4. (704 aa)
aggf1Angiogenic factor with G patch and FHA domains 1. (743 aa)
vegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (418 aa)
I3KWA4_ORENIPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (185 aa)
GAS1Growth arrest-specific 1b. (263 aa)
ENSONIP00000025853annotation not available (134 aa)
LOC100702089Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (351 aa)
I3KYD0_ORENIJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (327 aa)
LOC100692879Fibroblast growth factor binding protein 1b. (211 aa)
mydgfMyeloid-derived growth factor. (234 aa)
LOC106096946LRRCT domain-containing protein. (334 aa)
LOC100707786JunE proto-oncogene, AP-1 transcription factor subunit. (347 aa)
LOC100697209Secretogranin II (chromogranin C), b. (583 aa)
Prok1Prokineticin-1. (100 aa)
LOC100701144Leucine-rich alpha-2-glycoprotein. (332 aa)
LOC100693354Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
tgfaTransforming growth factor, alpha. (270 aa)
I3K4Y1_ORENIAndrogen receptor. (535 aa)
LOC100692931GRANULINS domain-containing protein. (211 aa)
ENSONIP00000035199Prokineticin. (99 aa)
VegfaVascular endothelial growth factor A isoform X3. (201 aa)
med1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1834 aa)
il10Interleukin 10. (275 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (438 aa)
I3K981_ORENICytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (498 aa)
sirt6Sirtuin 6. (356 aa)
Bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1033 aa)
I3KMU3_ORENIInsulin-like growth factor 1. (230 aa)
htr2b5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (478 aa)
LOC100705021Vasoactive intestinal peptide. (157 aa)
ENSONIP00000054096annotation not available (205 aa)
LOC100693478Progranulin. (210 aa)
I3JF61_ORENIBone morphogenetic protein 16. (580 aa)
granulinProgranulin. (206 aa)
agtr1Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (414 aa)
sp1Sp1 transcription factor. (726 aa)
I3KAU3_ORENIInsulin-like growth factor 2b. (217 aa)
id1Inhibitor of DNA binding 1, HLH protein. (130 aa)
tnfaip3Tumor necrosis factor, alpha-induced protein 3. (861 aa)
ENSONIP00000071122Junctional protein associated with coronary artery disease. (1369 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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