(95 nodes) Positive regulation of peptidyl-tyrosine phosphorylation network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100706019	Gremlin 1a, DAN family BMP antagonist. (236 aa)
	I3K0I9_ORENI	Neuregulin 1. (649 aa)
	LOC100702432	Uncharacterized protein. (441 aa)
	LOC100706624	Ephrin-A5a; Belongs to the ephrin family. (229 aa)
	I3K566_ORENI	Tumor necrosis factor receptor superfamily, member 1a. (373 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (679 aa)
	I3K9Y9_ORENI	Si:dkey-193c22.2. (2193 aa)
	LOC100698076	Neuregulin 2b. (726 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (501 aa)
	LOC100710479	GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. (475 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (394 aa)
	I3KLG7_ORENI	Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
	LOC100706746	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (358 aa)
	LOC100695167	G protein-coupled receptor, class C, group 5, member Bb. (422 aa)
	LOC100691361	Heparin-binding EGF-like growth factor a. (238 aa)
	LOC102079602	Uncharacterized protein. (130 aa)
	I3KSQ8_ORENI	TNFR-Cys domain-containing protein. (239 aa)
	LOC100711365	Interleukin 19 like. (178 aa)
	LOC100707843	Platelet/endothelial cell adhesion molecule 1. (793 aa)
	GREM1	Gremlin. (182 aa)
	cspg4	Chondroitin sulfate proteoglycan 4. (2304 aa)
	LOC100695462	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (145 aa)
	ABI1	Abl-interactor 1a. (511 aa)
	LOC100703100	Abl-interactor 1b. (500 aa)
	tgfa	Transforming growth factor, alpha. (270 aa)
	LOC100699223	Cytokine receptor-like factor 1b. (396 aa)
	ENSONIP00000032417	Uncharacterized protein LOC100702023 isoform X1. (699 aa)
	LOC100708728	Ephrin-A1a; Belongs to the ephrin family. (227 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (318 aa)
	unc119	Unc-119 lipid binding chaperone. (207 aa)
	ncf1	Neutrophil cytosolic factor 1. (421 aa)
	LOC100695496	Uncharacterized protein LOC100695496 isoform X2. (238 aa)
	Vegfa	Vascular endothelial growth factor A isoform X3. (201 aa)
	LOC100696076	GATA binding protein 1a. (457 aa)
	pak2	Non-specific serine/threonine protein kinase. (536 aa)
	LOC100709722	EGF-like domain-containing protein. (133 aa)
	il34	Interleukin 34. (257 aa)
	I3KIB4_ORENI	CD40 molecule, TNF receptor superfamily member 5. (193 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (775 aa)
	I3KMU3_ORENI	Insulin-like growth factor 1. (230 aa)
	LOC100689879	SH2 domain-containing protein 1B. (165 aa)
	vtn	Vitronectin a. (562 aa)
	LOC102082670	TNFR-Cys domain-containing protein. (245 aa)
	DGKQ	Diacylglycerol kinase. (974 aa)
	alkal2	ALK and LTK ligand 2a. (163 aa)
	LOC100692624	Vitronectin b. (437 aa)
	LOC102080107	Signal-transducing adaptor protein 1 isoform X1. (373 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (293 aa)
	RELN	Reelin. (3468 aa)
	LOC100710391	Cytokine receptor-like factor 1a. (414 aa)
	hax1	HCLS1 associated protein X-1. (330 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (570 aa)
	I3KAU3_ORENI	Insulin-like growth factor 2b. (217 aa)
	LOC100696920	Docking protein 7. (761 aa)
	nox4	NADPH oxidase 4. (605 aa)
	LOC100694799	acidPPc domain-containing protein. (323 aa)
	LOC100712331	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (545 aa)
	EFNA5	Ephrin A5; Belongs to the ephrin family. (230 aa)
	LOC100693895	Epithelial mitogen homolog (mouse). (164 aa)
	ENSONIP00000073708	Tumor necrosis factor receptor superfamily member 14. (245 aa)
	lrrk1	Uncharacterized protein. (2034 aa)
	LOC100710323	Si:dkey-237i9.8. (767 aa)
	LOC100702271	GMP_PDE_delta domain-containing protein. (256 aa)
	LOC100692440	ADAM metallopeptidase domain 17b. (876 aa)
	I3K153_ORENI	Uncharacterized protein. (375 aa)
	LOC112841626	Erythroid transcription factor-like isoform X1. (280 aa)
	LOC100534576	Preproghrelin. (153 aa)
	plpp3	Phospholipid phosphatase 3. (334 aa)
	LOC100705514	Ephrin-A1b; Belongs to the ephrin family. (274 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (463 aa)
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	ARHGEF2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (905 aa)
	adnp	Activity-dependent neuroprotector homeobox b. (1058 aa)
	I3IZY9_ORENI	ALK and LTK ligand 1. (156 aa)
	DOK7	Docking protein 7. (887 aa)
	gas6	Uncharacterized protein. (662 aa)
	I3J5B3_ORENI	Cas scaffold protein family member 4. (726 aa)
	ENSONIP00000004607	Low affinity immunoglobulin gamma Fc region receptor III-A. (338 aa)
	I3J6W8_ORENI	Ig-like domain-containing protein. (330 aa)
	nrp1	Neuropilin; Belongs to the neuropilin family. (999 aa)
	LOC100700935	ADAM metallopeptidase domain 17a. (851 aa)
	I3J8E6_ORENI	Uncharacterized protein. (2222 aa)
	LOC100704951	Poly [ADP-ribose] polymerase. (1792 aa)
	LOC100711745	Neuregulin 2a. (747 aa)
	gng10	Betacellulin, epidermal growth factor family member. (185 aa)
	LOC100707172	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (612 aa)
	I3JR76_ORENI	Uncharacterized protein. (238 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2537 aa)
	ercc6	Excision repair cross-complementation group 6. (1437 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1377 aa)
	arl2bp	ADP-ribosylation factor-like 2 binding protein. (205 aa)
	LOC100704015	Rho guanine nucleotide exchange factor (GEF) 1a. (909 aa)
	Rictor	RPTOR independent companion of MTOR, complex 2 a. (1788 aa)
	il6st	Uncharacterized protein. (893 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	I3J5B3_ORENI	ENSONIP00000029293	ENSONIP00000004053	Abl-interactor 1a.	Cas scaffold protein family member 4.	0.462
ABI1	LOC100703100	ENSONIP00000029293	ENSONIP00000029405	Abl-interactor 1a.	Abl-interactor 1b.	0.900
ABI1	PAK2	ENSONIP00000029293	ENSONIP00000000917	Abl-interactor 1a.	Non-specific serine/threonine protein kinase.	0.426
ABI1	pak2	ENSONIP00000029293	ENSONIP00000038583	Abl-interactor 1a.	Non-specific serine/threonine protein kinase.	0.426
ARHGEF2	LOC100704015	ENSONIP00000001746	ENSONIP00000012999	Rho/rac guanine nucleotide exchange factor (GEF) 2.	Rho guanine nucleotide exchange factor (GEF) 1a.	0.902
ENSONIP00000004607	I3J6W8_ORENI	ENSONIP00000004607	ENSONIP00000004608	Low affinity immunoglobulin gamma Fc region receptor III-A.	Ig-like domain-containing protein.	0.900
ENSONIP00000032417	I3K566_ORENI	ENSONIP00000032417	ENSONIP00000016261	Uncharacterized protein LOC100702023 isoform X1.	Tumor necrosis factor receptor superfamily, member 1a.	0.587
ENSONIP00000032417	LOC100695496	ENSONIP00000032417	ENSONIP00000035691	Uncharacterized protein LOC100702023 isoform X1.	Uncharacterized protein LOC100695496 isoform X2.	0.835
ENSONIP00000032417	LOC100699223	ENSONIP00000032417	ENSONIP00000030165	Uncharacterized protein LOC100702023 isoform X1.	Cytokine receptor-like factor 1b.	0.427
ENSONIP00000032417	LOC100710391	ENSONIP00000032417	ENSONIP00000055886	Uncharacterized protein LOC100702023 isoform X1.	Cytokine receptor-like factor 1a.	0.427
ENSONIP00000032417	il6st	ENSONIP00000032417	ENSONIP00000014614	Uncharacterized protein LOC100702023 isoform X1.	Uncharacterized protein.	0.930
GREM1	LOC100706019	ENSONIP00000026333	ENSONIP00000026713	Gremlin.	Gremlin 1a, DAN family BMP antagonist.	0.902
I3J5B3_ORENI	ABI1	ENSONIP00000004053	ENSONIP00000029293	Cas scaffold protein family member 4.	Abl-interactor 1a.	0.462
I3J5B3_ORENI	LOC100703100	ENSONIP00000004053	ENSONIP00000029405	Cas scaffold protein family member 4.	Abl-interactor 1b.	0.462
I3J6W8_ORENI	ENSONIP00000004607	ENSONIP00000004608	ENSONIP00000004607	Ig-like domain-containing protein.	Low affinity immunoglobulin gamma Fc region receptor III-A.	0.900
I3K0I9_ORENI	LOC100698076	ENSONIP00000014634	ENSONIP00000019844	Neuregulin 1.	Neuregulin 2b.	0.525
I3K0I9_ORENI	LOC100709722	ENSONIP00000014634	ENSONIP00000039207	Neuregulin 1.	EGF-like domain-containing protein.	0.500
I3K0I9_ORENI	gng10	ENSONIP00000014634	ENSONIP00000009591	Neuregulin 1.	Betacellulin, epidermal growth factor family member.	0.558
I3K566_ORENI	ENSONIP00000032417	ENSONIP00000016261	ENSONIP00000032417	Tumor necrosis factor receptor superfamily, member 1a.	Uncharacterized protein LOC100702023 isoform X1.	0.587
I3K566_ORENI	ripk2	ENSONIP00000016261	ENSONIP00000057830	Tumor necrosis factor receptor superfamily, member 1a.	Receptor-interacting serine-threonine kinase 2.	0.453