(14 nodes) Regulation of membrane protein ectodomain proteolysis network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TIMP3	TIMP metallopeptidase inhibitor 3. (285 aa)
	il10	Interleukin 10. (275 aa)
	LOC100703129	Sorting nexin. (579 aa)
	timp2	TIMP metallopeptidase inhibitor 2a. (220 aa)
	LOC100699941	Putative apolipoprotein E. (288 aa)
	timp4	TIMP metallopeptidase inhibitor 4, tandem duplicate 2. (224 aa)
	LOC100707019	Uncharacterized protein. (262 aa)
	LOC100707634	Sorting nexin. (636 aa)
	Sh3d19	SH3 domain containing 19. (1042 aa)
	LOC100707066	Interleukin-1. (244 aa)
	LOC100702284	TIMP metallopeptidase inhibitor 2b. (220 aa)
	NRDC	Nardilysin b (N-arginine dibasic convertase); Belongs to the peptidase M16 family. (1107 aa)
	LOC100534578	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	I3IXY5_ORENI	Nardilysin a (N-arginine dibasic convertase); Belongs to the peptidase M16 family. (1076 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100534578	LOC100699941	ENSONIP00000002809	ENSONIP00000020343	Tumor necrosis factor b (TNF superfamily, member 2).	Putative apolipoprotein E.	0.467
LOC100534578	LOC100707066	ENSONIP00000002809	ENSONIP00000010489	Tumor necrosis factor b (TNF superfamily, member 2).	Interleukin-1.	0.953
LOC100534578	il10	ENSONIP00000002809	ENSONIP00000038761	Tumor necrosis factor b (TNF superfamily, member 2).	Interleukin 10.	0.874
LOC100699941	LOC100534578	ENSONIP00000020343	ENSONIP00000002809	Putative apolipoprotein E.	Tumor necrosis factor b (TNF superfamily, member 2).	0.467
LOC100699941	LOC100707066	ENSONIP00000020343	ENSONIP00000010489	Putative apolipoprotein E.	Interleukin-1.	0.519
LOC100699941	il10	ENSONIP00000020343	ENSONIP00000038761	Putative apolipoprotein E.	Interleukin 10.	0.590
LOC100702284	TIMP3	ENSONIP00000006679	ENSONIP00000056235	TIMP metallopeptidase inhibitor 2b.	TIMP metallopeptidase inhibitor 3.	0.511
LOC100702284	il10	ENSONIP00000006679	ENSONIP00000038761	TIMP metallopeptidase inhibitor 2b.	Interleukin 10.	0.520
LOC100707019	LOC100707066	ENSONIP00000017280	ENSONIP00000010489	Uncharacterized protein.	Interleukin-1.	0.404
LOC100707019	il10	ENSONIP00000017280	ENSONIP00000038761	Uncharacterized protein.	Interleukin 10.	0.457
LOC100707066	LOC100534578	ENSONIP00000010489	ENSONIP00000002809	Interleukin-1.	Tumor necrosis factor b (TNF superfamily, member 2).	0.953
LOC100707066	LOC100699941	ENSONIP00000010489	ENSONIP00000020343	Interleukin-1.	Putative apolipoprotein E.	0.519
LOC100707066	LOC100707019	ENSONIP00000010489	ENSONIP00000017280	Interleukin-1.	Uncharacterized protein.	0.404
LOC100707066	il10	ENSONIP00000010489	ENSONIP00000038761	Interleukin-1.	Interleukin 10.	0.948
TIMP3	LOC100702284	ENSONIP00000056235	ENSONIP00000006679	TIMP metallopeptidase inhibitor 3.	TIMP metallopeptidase inhibitor 2b.	0.511
TIMP3	il10	ENSONIP00000056235	ENSONIP00000038761	TIMP metallopeptidase inhibitor 3.	Interleukin 10.	0.473
TIMP3	timp2	ENSONIP00000056235	ENSONIP00000029511	TIMP metallopeptidase inhibitor 3.	TIMP metallopeptidase inhibitor 2a.	0.532
il10	LOC100534578	ENSONIP00000038761	ENSONIP00000002809	Interleukin 10.	Tumor necrosis factor b (TNF superfamily, member 2).	0.874
il10	LOC100699941	ENSONIP00000038761	ENSONIP00000020343	Interleukin 10.	Putative apolipoprotein E.	0.590
il10	LOC100702284	ENSONIP00000038761	ENSONIP00000006679	Interleukin 10.	TIMP metallopeptidase inhibitor 2b.	0.520