(18 nodes) Lung morphogenesis network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRF	Serum response factor. (597 aa)
	I3JWF9_ORENI	MADS-box domain-containing protein. (506 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (410 aa)
	LOC100712573	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (637 aa)
	lama1	Laminin, alpha 1. (2770 aa)
	LOC100699984	Peptidase S72 domain-containing protein. (909 aa)
	hps1	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (676 aa)
	LOC100696456	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (298 aa)
	dag1	Dystroglycan 1. (903 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (538 aa)
	LOC100693354	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
	LOC100702144	Uncharacterized protein; Belongs to the peptidase C1 family. (330 aa)
	tcf21	Basic helix-loop-helix protein 21. (174 aa)
	ctsz	Cathepsin Z; Belongs to the peptidase C1 family. (303 aa)
	dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2047 aa)
	Hhip	Hedgehog interacting protein. (955 aa)
	stk40	Serine/threonine kinase 40. (439 aa)
	ctsh	Cathepsin H; Belongs to the peptidase C1 family. (324 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100696456	LOC100702144	ENSONIP00000023243	ENSONIP00000031986	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.408
LOC100696456	ctsh	ENSONIP00000023243	ENSONIP00000070506	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.408
LOC100699984	dag1	ENSONIP00000021921	ENSONIP00000023354	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.902
LOC100702144	LOC100696456	ENSONIP00000031986	ENSONIP00000023243	Uncharacterized protein; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.408
LOC100702144	ctsz	ENSONIP00000031986	ENSONIP00000056620	Uncharacterized protein; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.408
ctsh	LOC100696456	ENSONIP00000070506	ENSONIP00000023243	Cathepsin H; Belongs to the peptidase C1 family.	Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.	0.408
ctsh	ctsz	ENSONIP00000070506	ENSONIP00000056620	Cathepsin H; Belongs to the peptidase C1 family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.458
ctsz	LOC100702144	ENSONIP00000056620	ENSONIP00000031986	Cathepsin Z; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C1 family.	0.408
ctsz	ctsh	ENSONIP00000056620	ENSONIP00000070506	Cathepsin Z; Belongs to the peptidase C1 family.	Cathepsin H; Belongs to the peptidase C1 family.	0.458
dag1	LOC100699984	ENSONIP00000023354	ENSONIP00000021921	Dystroglycan 1.	Peptidase S72 domain-containing protein.	0.902