(26 nodes) Positive regulation of response to cytokine stimulus network (Oreochromis niloticus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1288 aa)
	gas6	Uncharacterized protein. (662 aa)
	LOC100700935	ADAM metallopeptidase domain 17a. (851 aa)
	LOC100704951	Poly [ADP-ribose] polymerase. (1792 aa)
	Prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (441 aa)
	ube2k	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	LOC100702432	Uncharacterized protein. (441 aa)
	mavs	CARD_2 domain-containing protein. (552 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (721 aa)
	LOC100702954	Interferon regulatory factor 3. (466 aa)
	Trim32	Tripartite motif containing 32. (681 aa)
	supt5h	Transcription elongation factor SPT5. (1087 aa)
	I3KPD0_ORENI	LSM14A mRNA processing body assembly factor a. (99 aa)
	LOC100708886	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	tbk1	TANK-binding kinase 1. (746 aa)
	med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1834 aa)
	c1qtnf4	C1q and TNF related 4. (360 aa)
	edn1	Endothelin 1. (202 aa)
	trim44	Tripartite motif containing 44. (375 aa)
	LOC100696773	Uncharacterized protein. (302 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (570 aa)
	ifih1	Interferon induced with helicase C domain 1. (1036 aa)
	Fadd	Uncharacterized protein. (209 aa)
	rnf185	Ring finger protein 185. (172 aa)
	LOC100692440	ADAM metallopeptidase domain 17b. (876 aa)
	Lsm14a	LSM14A mRNA processing body assembly factor. (106 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Fadd	Prkn	ENSONIP00000071989	ENSONIP00000009000	Uncharacterized protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.441
Fadd	ikbke	ENSONIP00000071989	ENSONIP00000024279	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.421
Fadd	mavs	ENSONIP00000071989	ENSONIP00000015464	Uncharacterized protein.	CARD_2 domain-containing protein.	0.667
Fadd	ripk2	ENSONIP00000071989	ENSONIP00000057830	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.724
Fadd	tbk1	ENSONIP00000071989	ENSONIP00000037971	Uncharacterized protein.	TANK-binding kinase 1.	0.421
LOC100702954	Trim32	ENSONIP00000025281	ENSONIP00000026301	Interferon regulatory factor 3.	Tripartite motif containing 32.	0.566
LOC100702954	ifih1	ENSONIP00000025281	ENSONIP00000059635	Interferon regulatory factor 3.	Interferon induced with helicase C domain 1.	0.722
LOC100702954	ikbke	ENSONIP00000025281	ENSONIP00000024279	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.990
LOC100702954	mavs	ENSONIP00000025281	ENSONIP00000015464	Interferon regulatory factor 3.	CARD_2 domain-containing protein.	0.978
LOC100702954	tbk1	ENSONIP00000025281	ENSONIP00000037971	Interferon regulatory factor 3.	TANK-binding kinase 1.	0.996
LOC100704951	ifih1	ENSONIP00000005684	ENSONIP00000059635	Poly [ADP-ribose] polymerase.	Interferon induced with helicase C domain 1.	0.750
LOC100708886	Prkn	ENSONIP00000031559	ENSONIP00000009000	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.619
LOC100708886	ube2k	ENSONIP00000031559	ENSONIP00000011335	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.900
Lsm14a	dhx9	ENSONIP00000080734	ENSONIP00000000368	LSM14A mRNA processing body assembly factor.	DEAH (Asp-Glu-Ala-His) box helicase 9.	0.649
Prkn	Fadd	ENSONIP00000009000	ENSONIP00000071989	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Uncharacterized protein.	0.441
Prkn	LOC100708886	ENSONIP00000009000	ENSONIP00000031559	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.619
Prkn	ikbke	ENSONIP00000009000	ENSONIP00000024279	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.412
Prkn	ripk2	ENSONIP00000009000	ENSONIP00000057830	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Receptor-interacting serine-threonine kinase 2.	0.475
Prkn	tbk1	ENSONIP00000009000	ENSONIP00000037971	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	TANK-binding kinase 1.	0.412
Prkn	ube2k	ENSONIP00000009000	ENSONIP00000011335	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.619