(161 nodes) Regulation of small molecule metabolic process network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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Your Input:
	guca1a	Guanylate cyclase activator 1A. (189 aa)
	I3ITT0_ORENI	TP53 induced glycolysis regulatory phosphatase b. (318 aa)
	LOC100705084	Si:ch73-352p4.8. (532 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (328 aa)
	LOC100700105	Tribbles pseudokinase 3. (353 aa)
	LOC100704320	ATCAY kinesin light chain interacting caytaxin a. (334 aa)
	LOC100534578	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	LOC100704762	Flavin-containing monooxygenase. (564 aa)
	Foxk1	Forkhead box K1. (711 aa)
	LOC100701817	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	I3J709_ORENI	J domain-containing protein. (257 aa)
	h6pd	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
	LOC100697834	Flavin-containing monooxygenase. (431 aa)
	zbtb20	Zinc finger and BTB domain containing 20. (678 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	lpgat1	Lysophosphatidylglycerol acyltransferase 1. (372 aa)
	Rd3	Retinal degeneration 3, GUCY2D regulator. (210 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (301 aa)
	scap	SREBF chaperone. (1326 aa)
	LOC100707395	Suppressor of glucose, autophagy associated 1. (1806 aa)
	wdtc1	WD and tetratricopeptide repeats 1. (675 aa)
	clybl	Citrate lyase beta like. (343 aa)
	Prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (441 aa)
	Prmt3	Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa)
	gnmt	Glycine N-methyltransferase. (295 aa)
	LOC100707066	Interleukin-1. (244 aa)
	srebf2	Sterol regulatory element binding transcription factor 2. (1178 aa)
	ak4	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
	IGFBP4	Insulin like growth factor binding protein 4. (260 aa)
	I3JR57_ORENI	FATP synthase c subunit lysine N-methyltransferase. (225 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2537 aa)
	I3JS28_ORENI	Nuclear receptor subfamily 1, group d, member 1. (552 aa)
	jmjd8	Jumonji domain containing 8. (270 aa)
	snai2	Snail family zinc finger 2. (260 aa)
	LOC100704864	Forkhead box K2. (609 aa)
	LOC100701603	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (306 aa)
	IGFBP3	Insulin like growth factor binding protein 3. (286 aa)
	LOC102082684	Ubiquitin-like domain-containing protein. (481 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (712 aa)
	mlycd	Malonyl-CoA decarboxylase. (511 aa)
	etfbkmt	Electron transfer flavoprotein subunit beta lysine methyltransferase. (258 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (270 aa)
	ncor2	Nuclear receptor corepressor 2. (2362 aa)
	dab2	DAB adaptor protein 2. (782 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (580 aa)
	fam3c	Family with sequence similarity 3 member C. (227 aa)
	LOC102079941	Apolipoprotein Ba. (4368 aa)
	ppard	PPAR beta. (512 aa)
	gckr	Uncharacterized protein. (580 aa)
	flcn	Folliculin. (560 aa)
	ncor1	Nuclear receptor corepressor 1. (2351 aa)
	bad	BCL2 associated agonist of cell death b. (158 aa)
	arl2	ADP-ribosylation factor-like 2; Belongs to the small GTPase superfamily. Arf family. (184 aa)
	LOC100696033	Tetratricopeptide repeat domain 39B. (580 aa)
	LOC100707019	Uncharacterized protein. (262 aa)
	pparg	Peroxisome proliferator activated receptor gamma. (556 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (310 aa)
	I3KBH0_ORENI	Vitellogenin domain-containing protein. (736 aa)
	lepa	Leptin A. (161 aa)
	LOC100698852	Si:dkey-190g11.3. (217 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1115 aa)
	PPTC7	Protein phosphatase; Belongs to the PP2C family. (297 aa)
	LOC100699941	Putative apolipoprotein E. (288 aa)
	lacc1	Laccase (multicopper oxidoreductase) domain containing 1. (414 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (501 aa)
	brca1	Uncharacterized protein. (1392 aa)
	dusp12	Dual specificity phosphatase 12. (299 aa)
	LOC100708634	Apolipoprotein A-Ib. (263 aa)
	guca1b	Guanylate cyclase activator 1B. (197 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	sirt7	Sirtuin 7. (406 aa)
	LOC100693787	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	arv1	ARV1 homolog, fatty acid homeostasis modulator. (239 aa)
	LOC100693947	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (165 aa)
	LOC100708764	Uncharacterized protein. (616 aa)
	lcmt1	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (325 aa)
	MTLN	Mitoregulin. (56 aa)
	fh	Fumarate hydratase. (499 aa)
	LOC106098181	Uncharacterized protein. (195 aa)
	I3KZG3_ORENI	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (336 aa)
	LOC100698181	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (469 aa)
	ppargc1a	PPARG coactivator 1 alpha. (1284 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (587 aa)
	rusc1	RUN and SH3 domain containing 1. (1610 aa)
	Dnajc30	DnaJ homolog subfamily C member 30. (231 aa)
	pdk3	Protein-serine/threonine kinase. (434 aa)
	LOC100692334	Dickkopf WNT signaling pathway inhibitor 3a. (292 aa)
	I3J3L5_ORENI	Dimethylaniline monooxygenase [N-oxide-forming]. (536 aa)
	I3JEN3_ORENI	Uncharacterized protein. (601 aa)
	LOC100699579	Nuclear receptor subfamily 1, group H, member 5. (517 aa)
	LOC100710146	TP53 induced glycolysis regulatory phosphatase a. (271 aa)
	LOC100696016	Cytochrome c oxidase assembly homolog 11 (yeast). (257 aa)
	LOC100689844	Battenin. (441 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (488 aa)
	LOC100700851	Guanylate cyclase activator 1d. (188 aa)
	LOC100712552	Uncharacterized protein. (108 aa)
	LOC100701650	Protein-serine/threonine kinase. (429 aa)
	sirt6	Sirtuin 6. (356 aa)
	LOC100702182	Zgc:158403. (601 aa)
	LOC102083193	Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform X1. (410 aa)
	pibf1	Progesterone immunomodulatory binding factor 1. (775 aa)
	I3KMU3_ORENI	Insulin-like growth factor 1. (230 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (627 aa)
	ENSONIP00000043344	annotation not available (98 aa)
	acmsd	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (337 aa)
	ttc39a	Tetratricopeptide repeat domain 39A. (618 aa)
	DGKQ	Diacylglycerol kinase. (974 aa)
	LOC100709119	C1q and TNF related 6b. (242 aa)
	ogt	O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1. (1073 aa)
	LOC100692890	RAN binding protein 2. (3035 aa)
	p2ry6	Pyrimidinergic receptor P2Y6. (373 aa)
	LOC112843185	General transcription factor II-I repeat domain-containing protein 2B-like. (606 aa)
	LOC100704224	Dimethylaniline monooxygenase [N-oxide-forming]. (553 aa)
	slc7a11	Solute carrier family 7 member 11. (514 aa)
	ENSONIP00000053607	Dimethylaniline monooxygenase [N-oxide-forming] 5. (560 aa)
	pid1	Phosphotyrosine interaction domain containing 1. (232 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (481 aa)
	LOC100703165	Peroxiredoxin like 2C. (225 aa)
	ENSONIP00000055812	annotation not available (389 aa)
	I3JN85_ORENI	Uncharacterized protein. (601 aa)
	I3KQI1_ORENI	DUF4371 domain-containing protein. (528 aa)
	ephx2	Epoxide hydrolase 2, cytoplasmic. (564 aa)
	LOC100712504	PDZ domain containing 3b. (522 aa)
	ENSONIP00000058414	Parathyroid hormone 1a. (90 aa)
	LOC100707156	Dimethylaniline monooxygenase [N-oxide-forming] 5 isoform X1. (568 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (577 aa)
	pdk4	Protein-serine/threonine kinase. (441 aa)
	I3IW71_ORENI	Uncharacterized protein. (103 aa)
	LOC100698100	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	ncs1	Neuronal calcium sensor 1a. (190 aa)
	pdk1	Protein-serine/threonine kinase. (430 aa)
	ENSONIP00000066221	annotation not available (501 aa)
	tysnd1	Serine protease; Belongs to the peptidase S1B family. (590 aa)
	LOC100695329	ATP-binding cassette, sub-family G (WHITE), member 4b. (650 aa)
	I3KAU3_ORENI	Insulin-like growth factor 2b. (217 aa)
	lepr	Uncharacterized protein. (1190 aa)
	ENSONIP00000070671	annotation not available (76 aa)
	podn	Podocan. (643 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	ENSONIP00000071939	Cytidine deaminase. (130 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (501 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (182 aa)
	LOC100698988	E1A binding protein p300 a. (2777 aa)
	I3JFT4_ORENI	Uncharacterized protein. (2460 aa)
	abcd2	ATP-binding cassette, sub-family D (ALD), member 2. (751 aa)
	Lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1023 aa)
	LOC100700725	E1A binding protein p300 b. (2799 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (436 aa)
	bckdk	Protein-serine/threonine kinase. (482 aa)
	abcg4	ABC transporter domain-containing protein. (665 aa)
	Slc27a4	Solute carrier family 27 member 4. (660 aa)
	plek	Pleckstrin. (391 aa)
	LOC100707699	Nuclear receptor subfamily 1, group D, member 4b. (596 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1177 aa)
	LOC100704493	Dimethylaniline monooxygenase [N-oxide-forming]. (551 aa)
	LOC106098827	General transcription factor II-I repeat domain-containing protein 2. (343 aa)
	LOC100691436	Midnolin. (568 aa)
	Tspo	Translocator protein. (182 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ3	ENSONIP00000053607	ENSONIP00000000153	ENSONIP00000053607	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Dimethylaniline monooxygenase [N-oxide-forming] 5.	0.445
COQ3	I3J3L5_ORENI	ENSONIP00000000153	ENSONIP00000033220	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Dimethylaniline monooxygenase [N-oxide-forming].	0.445
COQ3	LOC100696016	ENSONIP00000000153	ENSONIP00000034080	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Cytochrome c oxidase assembly homolog 11 (yeast).	0.444
COQ3	LOC100697834	ENSONIP00000000153	ENSONIP00000005236	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Flavin-containing monooxygenase.	0.445
COQ3	LOC100704224	ENSONIP00000000153	ENSONIP00000051825	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Dimethylaniline monooxygenase [N-oxide-forming].	0.445
COQ3	LOC100704493	ENSONIP00000000153	ENSONIP00000080068	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Dimethylaniline monooxygenase [N-oxide-forming].	0.445
COQ3	LOC100704762	ENSONIP00000000153	ENSONIP00000003451	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Flavin-containing monooxygenase.	0.445
COQ3	LOC100707156	ENSONIP00000000153	ENSONIP00000061800	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Dimethylaniline monooxygenase [N-oxide-forming] 5 isoform X1.	0.445
COQ3	acadm	ENSONIP00000000153	ENSONIP00000075459	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Acyl-CoA dehydrogenase medium chain.	0.426
COQ3	ephx2	ENSONIP00000000153	ENSONIP00000057273	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	Epoxide hydrolase 2, cytoplasmic.	0.814
DKK3	dab2	ENSONIP00000013810	ENSONIP00000013998	Dickkopf WNT signaling pathway inhibitor 3.	DAB adaptor protein 2.	0.442
ENSONIP00000053607	COQ3	ENSONIP00000053607	ENSONIP00000000153	Dimethylaniline monooxygenase [N-oxide-forming] 5.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.445
ENSONIP00000053607	ephx2	ENSONIP00000053607	ENSONIP00000057273	Dimethylaniline monooxygenase [N-oxide-forming] 5.	Epoxide hydrolase 2, cytoplasmic.	0.420
ENSONIP00000058414	I3KMU3_ORENI	ENSONIP00000058414	ENSONIP00000042664	Parathyroid hormone 1a.	Insulin-like growth factor 1.	0.586
ENSONIP00000071939	LOC100701817	ENSONIP00000071939	ENSONIP00000004442	Cytidine deaminase.	Protein phosphatase; Belongs to the PP2C family.	0.444
ENSONIP00000071939	PPTC7	ENSONIP00000071939	ENSONIP00000020101	Cytidine deaminase.	Protein phosphatase; Belongs to the PP2C family.	0.444
Foxk1	ogt	ENSONIP00000004054	ENSONIP00000047879	Forkhead box K1.	O-linked N-acetylglucosamine (GlcNAc) transferase, tandem duplicate 1.	0.703
I3ITT0_ORENI	LOC100710146	ENSONIP00000000019	ENSONIP00000033731	TP53 induced glycolysis regulatory phosphatase b.	TP53 induced glycolysis regulatory phosphatase a.	0.903
I3ITT0_ORENI	h6pd	ENSONIP00000000019	ENSONIP00000005085	TP53 induced glycolysis regulatory phosphatase b.	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase).	0.467
I3J3L5_ORENI	COQ3	ENSONIP00000033220	ENSONIP00000000153	Dimethylaniline monooxygenase [N-oxide-forming].	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.445