(39 nodes) Protein K63-linked ubiquitination network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100706848	Si:ch211-81a5.1. (297 aa)
	RNF126	Ring finger protein 126. (330 aa)
	traf2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (524 aa)
	I3J513_ORENI	UBIQUITIN_CONJUGAT_2 domain-containing protein. (200 aa)
	LOC100709870	Ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	BFAR	Bifunctional apoptosis regulator. (460 aa)
	rnf8	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (489 aa)
	Prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (441 aa)
	LOC102079525	ZFP91-CNTF readthrough (NMD candidate). (776 aa)
	LOC100697163	E3 ubiquitin-protein ligase. (888 aa)
	LOC100696319	Ring finger protein 126. (311 aa)
	I3JW29_ORENI	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC100708442	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (598 aa)
	I3K4G6_ORENI	RING-type domain-containing protein. (3990 aa)
	ENSONIP00000020099	Ubiquitin-conjugating enzyme E2 G1 isoform X2. (94 aa)
	LOC100697176	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (587 aa)
	LOC100691685	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (442 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (1389 aa)
	rnf152	Ring finger protein 152. (165 aa)
	LOC102081064	E3 ubiquitin-protein ligase ZFP91 isoform X1. (680 aa)
	hectd1	HECT domain containing 1. (2614 aa)
	LOC100712348	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (254 aa)
	ube2v2	Ubiquitin-conjugating enzyme E2 variant 2. (148 aa)
	ube2g1	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
	LOC102081483	Ubiquitin-conjugating enzyme E2 variant 1. (153 aa)
	Traf3ip2	SEFIR domain-containing protein. (115 aa)
	ENSONIP00000041907	annotation not available (108 aa)
	prpf19	Pre-mRNA processing factor 19. (1489 aa)
	rnf115	Ring finger protein 115. (340 aa)
	ENSONIP00000051840	Uncharacterized protein LOC100709415 isoform X1. (121 aa)
	LOC100694718	E3 ubiquitin-protein ligase. (877 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (594 aa)
	LOC100699741	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (138 aa)
	arih2	RBR-type E3 ubiquitin transferase. (507 aa)
	rnf213	Ring finger protein 213a. (4290 aa)
	ENSONIP00000075286	annotation not available (92 aa)
	Rnf4	E3 ubiquitin-protein ligase RNF4 isoform X1. (192 aa)
	LOC100701435	Uncharacterized protein LOC100701435. (441 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BFAR	I3J513_ORENI	ENSONIP00000004863	ENSONIP00000003953	Bifunctional apoptosis regulator.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.440
BFAR	LOC102081483	ENSONIP00000004863	ENSONIP00000037071	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 1.	0.467
BFAR	rnf8	ENSONIP00000004863	ENSONIP00000007491	Bifunctional apoptosis regulator.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.553
BFAR	ube2v2	ENSONIP00000004863	ENSONIP00000030823	Bifunctional apoptosis regulator.	Ubiquitin-conjugating enzyme E2 variant 2.	0.440
ENSONIP00000020099	I3J513_ORENI	ENSONIP00000020099	ENSONIP00000003953	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.701
ENSONIP00000020099	LOC100699741	ENSONIP00000020099	ENSONIP00000060489	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.483
ENSONIP00000020099	LOC100709870	ENSONIP00000020099	ENSONIP00000004770	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	Ubiquitin-conjugating enzyme E2G 1b (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.901
ENSONIP00000020099	LOC100712348	ENSONIP00000020099	ENSONIP00000030218	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.	0.483
ENSONIP00000020099	LOC102081483	ENSONIP00000020099	ENSONIP00000037071	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	Ubiquitin-conjugating enzyme E2 variant 1.	0.917
ENSONIP00000020099	Prkn	ENSONIP00000020099	ENSONIP00000009000	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.664
ENSONIP00000020099	UBE2O	ENSONIP00000020099	ENSONIP00000022985	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	Ubiquitin conjugating enzyme E2 O.	0.637
ENSONIP00000020099	rnf8	ENSONIP00000020099	ENSONIP00000007491	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.482
ENSONIP00000020099	ube2g1	ENSONIP00000020099	ENSONIP00000036134	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.	0.901
ENSONIP00000020099	ube2v2	ENSONIP00000020099	ENSONIP00000030823	Ubiquitin-conjugating enzyme E2 G1 isoform X2.	Ubiquitin-conjugating enzyme E2 variant 2.	0.756
ENSONIP00000051840	LOC100697176	ENSONIP00000051840	ENSONIP00000020311	Uncharacterized protein LOC100709415 isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.477
ENSONIP00000051840	LOC100701435	ENSONIP00000051840	ENSONIP00000079615	Uncharacterized protein LOC100709415 isoform X1.	Uncharacterized protein LOC100701435.	0.900
ENSONIP00000051840	Traf3ip2	ENSONIP00000051840	ENSONIP00000038158	Uncharacterized protein LOC100709415 isoform X1.	SEFIR domain-containing protein.	0.901
ENSONIP00000051840	traf3	ENSONIP00000051840	ENSONIP00000059949	Uncharacterized protein LOC100709415 isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.477
ENSONIP00000051840	traf6	ENSONIP00000051840	ENSONIP00000057481	Uncharacterized protein LOC100709415 isoform X1.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.725
ENSONIP00000075286	I3J513_ORENI	ENSONIP00000075286	ENSONIP00000003953	annotation not available	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.701