(25 nodes) U2-type catalytic step 2 spliceosome network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	crnkl1	Crooked neck pre-mRNA splicing factor 1. (758 aa)
	snw1	SNW domain containing 1. (536 aa)
	snrpd3	Small nuclear ribonucleoprotein Sm D3. (127 aa)
	Cwc22	MI domain-containing protein. (1025 aa)
	prpf8	Pre-mRNA processing factor 8. (2350 aa)
	bcas2	BCAS2 pre-mRNA processing factor. (225 aa)
	Snrpa1	Small nuclear ribonucleoprotein polypeptide A. (291 aa)
	rbm22	RNA binding motif protein 22. (427 aa)
	cdc40	Cell division cycle 40 homolog (S. cerevisiae). (581 aa)
	ppil1	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (202 aa)
	dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8. (1213 aa)
	dhx34	DEAH (Asp-Glu-Ala-His) box polypeptide 34. (1172 aa)
	xab2	XPA binding protein 2. (854 aa)
	syf2	SYF2 pre-mRNA-splicing factor. (239 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1473 aa)
	snrnp40	Small nuclear ribonucleoprotein 40 (U5). (347 aa)
	ppie	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (309 aa)
	snrpd2	Small nuclear ribonucleoprotein Sm D2. (118 aa)
	eftud2	Elongation factor Tu GTP binding domain containing 2. (1011 aa)
	snrpb	Small nuclear ribonucleoprotein-associated protein. (256 aa)
	cwc15	CWC15 spliceosome associated protein homolog. (237 aa)
	plrg1	Pleiotropic regulator 1. (513 aa)
	Snrpf	Small nuclear ribonucleoprotein F. (85 aa)
	snrpd1	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (110 aa)
	snrpe	Small nuclear ribonucleoprotein E. (92 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cwc22	Snrpa1	ENSONIP00000008688	ENSONIP00000014349	MI domain-containing protein.	Small nuclear ribonucleoprotein polypeptide A.	0.912
Cwc22	Snrpf	ENSONIP00000008688	ENSONIP00000068044	MI domain-containing protein.	Small nuclear ribonucleoprotein F.	0.844
Cwc22	aqr	ENSONIP00000008688	ENSONIP00000051878	MI domain-containing protein.	Aquarius intron-binding spliceosomal factor.	0.852
Cwc22	bcas2	ENSONIP00000008688	ENSONIP00000011614	MI domain-containing protein.	BCAS2 pre-mRNA processing factor.	0.630
Cwc22	cdc40	ENSONIP00000008688	ENSONIP00000016887	MI domain-containing protein.	Cell division cycle 40 homolog (S. cerevisiae).	0.999
Cwc22	crnkl1	ENSONIP00000008688	ENSONIP00000072834	MI domain-containing protein.	Crooked neck pre-mRNA splicing factor 1.	0.977
Cwc22	cwc15	ENSONIP00000008688	ENSONIP00000064198	MI domain-containing protein.	CWC15 spliceosome associated protein homolog.	0.931
Cwc22	dhx34	ENSONIP00000008688	ENSONIP00000038932	MI domain-containing protein.	DEAH (Asp-Glu-Ala-His) box polypeptide 34.	0.916
Cwc22	dhx8	ENSONIP00000008688	ENSONIP00000022980	MI domain-containing protein.	DEAH (Asp-Glu-Ala-His) box polypeptide 8.	0.916
Cwc22	eftud2	ENSONIP00000008688	ENSONIP00000055002	MI domain-containing protein.	Elongation factor Tu GTP binding domain containing 2.	0.994
Cwc22	plrg1	ENSONIP00000008688	ENSONIP00000065166	MI domain-containing protein.	Pleiotropic regulator 1.	0.948
Cwc22	ppie	ENSONIP00000008688	ENSONIP00000054207	MI domain-containing protein.	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.	0.741
Cwc22	ppil1	ENSONIP00000008688	ENSONIP00000018120	MI domain-containing protein.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.967
Cwc22	prpf8	ENSONIP00000008688	ENSONIP00000010265	MI domain-containing protein.	Pre-mRNA processing factor 8.	0.991
Cwc22	rbm22	ENSONIP00000008688	ENSONIP00000016411	MI domain-containing protein.	RNA binding motif protein 22.	0.905
Cwc22	snrnp40	ENSONIP00000008688	ENSONIP00000053667	MI domain-containing protein.	Small nuclear ribonucleoprotein 40 (U5).	0.578
Cwc22	snrpb	ENSONIP00000008688	ENSONIP00000056472	MI domain-containing protein.	Small nuclear ribonucleoprotein-associated protein.	0.631
Cwc22	snrpd1	ENSONIP00000008688	ENSONIP00000068638	MI domain-containing protein.	Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.	0.866
Cwc22	snrpd2	ENSONIP00000008688	ENSONIP00000054582	MI domain-containing protein.	Small nuclear ribonucleoprotein Sm D2.	0.882
Cwc22	snrpd3	ENSONIP00000008688	ENSONIP00000004821	MI domain-containing protein.	Small nuclear ribonucleoprotein Sm D3.	0.868