STRINGSTRING
fermt1 fermt1 LOC109194384 LOC109194384 Hmga2 Hmga2 atxn1l atxn1l LOC100694653 LOC100694653 sox17 sox17 kdf1 kdf1 LOC100691607 LOC100691607 I3JV01_ORENI I3JV01_ORENI ptprc ptprc dgcr8 dgcr8 LOC100712573 LOC100712573 Nf1 Nf1 LOC106098551 LOC106098551 I3KHI5_ORENI I3KHI5_ORENI pdcd2 pdcd2 LOC100707945 LOC100707945 fgf4 fgf4 TGFBR2 TGFBR2 vegfc vegfc nf2 nf2 LOC100711530 LOC100711530 sirt6 sirt6 LOC100708747 LOC100708747 AGO3 AGO3 Kdm1a Kdm1a EIF2C3 EIF2C3 ENSONIP00000064740 ENSONIP00000064740 LOC100697642 LOC100697642
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fermt1Fermitin family member 1. (700 aa)
LOC109194384Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (208 aa)
Hmga2Uncharacterized protein. (132 aa)
atxn1lAtaxin 1-like. (840 aa)
LOC100694653Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
sox17SRY-box transcription factor 17. (397 aa)
kdf1Keratinocyte differentiation factor 1a. (390 aa)
LOC100691607Uncharacterized protein. (693 aa)
I3JV01_ORENIProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (408 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1377 aa)
dgcr8DGCR8 microprocessor complex subunit. (777 aa)
LOC100712573Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (637 aa)
Nf1Neurofibromin 1b. (2742 aa)
LOC106098551Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (614 aa)
I3KHI5_ORENIArgonaute RISC component 1; Belongs to the argonaute family. (865 aa)
pdcd2Programmed cell death 2. (366 aa)
LOC100707945Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (538 aa)
vegfcVascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (418 aa)
nf2Neurofibromin 2a (merlin). (632 aa)
LOC100711530SRY-box transcription factor 18. (565 aa)
sirt6Sirtuin 6. (356 aa)
LOC100708747Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (903 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (916 aa)
Kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (864 aa)
EIF2C3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily. (903 aa)
ENSONIP00000064740Cyclin-dependent kinase 4 inhibitor C isoform X2. (172 aa)
LOC100697642Neurofibromin 2b (merlin). (603 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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