(23 nodes) Regulation of DNA methylation-dependent heterochromatin assembly network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSONIP00000037239	annotation not available (353 aa)
	ENSONIP00000040152	Uncharacterized protein LOC109195389. (354 aa)
	LOC102078390	Protein TASOR isoform X1. (675 aa)
	Kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (864 aa)
	ENSONIP00000055990	annotation not available (364 aa)
	LOC112843493	DDE_Tnp_1_7 domain-containing protein. (425 aa)
	LOC112843493-2	Uncharacterized LOC112843493. (425 aa)
	atf7ip2	Activating transcription factor 7-interacting protein 2 isoform X1. (432 aa)
	LOC100700176	Atherin isoform X1. (416 aa)
	ENSONIP00000075405	annotation not available (288 aa)
	ENSONIP00000075353	annotation not available (325 aa)
	tasor	Transcription activation suppressor a. (2153 aa)
	setdb1	SET domain bifurcated histone lysine methyltransferase 1b. (1230 aa)
	creg1	Uncharacterized protein. (644 aa)
	Aicda	Activation-induced cytidine deaminase. (281 aa)
	morc2	MORC family CW-type zinc finger 2. (1047 aa)
	ENSONIP00000017541	Uncharacterized protein LOC112844609. (356 aa)
	I3KNJ8_ORENI	Activating transcription factor 7 interacting protein. (1127 aa)
	ENSONIP00000027150	annotation not available (398 aa)
	ENSONIP00000027429	annotation not available (367 aa)
	dnmt1	DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1510 aa)
	I3KHR9_ORENI	Sterile alpha motif domain containing 1b. (92 aa)
	ENSONIP00000037156	Uncharacterized protein LOC112848329. (538 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000017541	creg1	ENSONIP00000017541	ENSONIP00000011317	Uncharacterized protein LOC112844609.	Uncharacterized protein.	0.688
ENSONIP00000017541	setdb1	ENSONIP00000017541	ENSONIP00000008136	Uncharacterized protein LOC112844609.	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000027150	creg1	ENSONIP00000027150	ENSONIP00000011317	annotation not available	Uncharacterized protein.	0.688
ENSONIP00000027150	setdb1	ENSONIP00000027150	ENSONIP00000008136	annotation not available	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000027429	creg1	ENSONIP00000027429	ENSONIP00000011317	annotation not available	Uncharacterized protein.	0.688
ENSONIP00000027429	setdb1	ENSONIP00000027429	ENSONIP00000008136	annotation not available	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000037156	creg1	ENSONIP00000037156	ENSONIP00000011317	Uncharacterized protein LOC112848329.	Uncharacterized protein.	0.688
ENSONIP00000037156	setdb1	ENSONIP00000037156	ENSONIP00000008136	Uncharacterized protein LOC112848329.	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000037239	creg1	ENSONIP00000037239	ENSONIP00000011317	annotation not available	Uncharacterized protein.	0.688
ENSONIP00000037239	setdb1	ENSONIP00000037239	ENSONIP00000008136	annotation not available	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000040152	creg1	ENSONIP00000040152	ENSONIP00000011317	Uncharacterized protein LOC109195389.	Uncharacterized protein.	0.688
ENSONIP00000040152	setdb1	ENSONIP00000040152	ENSONIP00000008136	Uncharacterized protein LOC109195389.	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000055990	creg1	ENSONIP00000055990	ENSONIP00000011317	annotation not available	Uncharacterized protein.	0.688
ENSONIP00000055990	setdb1	ENSONIP00000055990	ENSONIP00000008136	annotation not available	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000075353	creg1	ENSONIP00000075353	ENSONIP00000011317	annotation not available	Uncharacterized protein.	0.688
ENSONIP00000075353	setdb1	ENSONIP00000075353	ENSONIP00000008136	annotation not available	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
ENSONIP00000075405	creg1	ENSONIP00000075405	ENSONIP00000011317	annotation not available	Uncharacterized protein.	0.688
ENSONIP00000075405	setdb1	ENSONIP00000075405	ENSONIP00000008136	annotation not available	SET domain bifurcated histone lysine methyltransferase 1b.	0.688
I3KNJ8_ORENI	creg1	ENSONIP00000022693	ENSONIP00000011317	Activating transcription factor 7 interacting protein.	Uncharacterized protein.	0.900
I3KNJ8_ORENI	setdb1	ENSONIP00000022693	ENSONIP00000008136	Activating transcription factor 7 interacting protein.	SET domain bifurcated histone lysine methyltransferase 1b.	0.900