(72 nodes) Regulation of G1/S transition of mitotic cell cycle network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mblac1	Metallo-beta-lactamase domain containing 1. (222 aa)
	I3IU26_ORENI	Lysine (K)-specific methyltransferase 2E. (1590 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (819 aa)
	rb1	Retinoblastoma 1. (919 aa)
	LOC100707642	Cyclin D2, b; Belongs to the cyclin family. (294 aa)
	wac	WW domain containing adaptor with coiled-coil a. (563 aa)
	Sass6	SAS-6 centriolar assembly protein. (588 aa)
	ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2. (267 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (668 aa)
	LOC100692710	Cleavage and polyadenylation specific factor 3. (758 aa)
	plrg1	Pleiotropic regulator 1. (513 aa)
	ENSONIP00000064740	Cyclin-dependent kinase 4 inhibitor C isoform X2. (172 aa)
	fbxo31	F-box protein 31. (585 aa)
	LOC100703282	Cyclin-dependent kinase inhibitor 1B. (168 aa)
	crlf3	Cytokine receptor-like factor 3. (471 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	appl1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (708 aa)
	brd7	Bromodomain containing 7. (614 aa)
	cdc73	Ro60, Y RNA binding protein. (530 aa)
	fhl1	Four and a half LIM domains 1a. (305 aa)
	cdkn2d	Cyclin-dependent kinase 4 inhibitor D. (164 aa)
	ENSONIP00000041766	Cyclin-dependent kinase inhibitor 1B. (179 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (325 aa)
	ENSONIP00000039288	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase. (264 aa)
	LOC100707378	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (127 aa)
	ctdspl	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase. (323 aa)
	LOC100698323	Cyclin D2, a; Belongs to the cyclin family. (297 aa)
	Cul4b	Cullin-4B. (869 aa)
	LSM10	LSM10, U7 small nuclear RNA associated. (121 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	dcun1d3	DCN1-like protein. (326 aa)
	LOC100696120	WW domain-containing protein. (526 aa)
	stox1	Storkhead box 1. (1089 aa)
	LOC100692495	Retinoblastoma-like 2 (p130). (1078 aa)
	I3KPB3_ORENI	Autophagy/beclin-1 regulator 1b. (1278 aa)
	Pkd1	Polycystic kidney disease 1a. (4572 aa)
	lsm11	LSM11, U7 small nuclear RNA associated. (338 aa)
	I3KLB2_ORENI	Uncharacterized protein. (200 aa)
	I3KHI6_ORENI	Regulator of cell cycle. (128 aa)
	LOC100691308	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b. (292 aa)
	LOC100690631	P53-induced death domain protein 1. (858 aa)
	I3KDT0_ORENI	BAF chromatin remodeling complex subunit BCL7A. (168 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (525 aa)
	kif14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1616 aa)
	CTDSP1	CTD small phosphatase 1. (262 aa)
	LOC100692440	ADAM metallopeptidase domain 17b. (876 aa)
	tm4sf5	Transmembrane 4 L six family member 5. (217 aa)
	e2f7	E2F transcription factor 7. (752 aa)
	rfwd3	Ring finger and WD repeat domain 3. (670 aa)
	pla2g4a	Phospholipase A2. (745 aa)
	e2f1	E2F transcription factor 1. (454 aa)
	LOC100693791	Four and a half LIM domains 1b. (279 aa)
	psme1	Proteasome activator subunit 1. (249 aa)
	LOC100698862	CASP2 and RIPK1 domain containing adaptor with death domain. (200 aa)
	fbxo7	F-box protein 7. (504 aa)
	mtbp	MDM2 binding protein. (869 aa)
	psme2	Proteasome activator subunit 2. (245 aa)
	rbl1	Retinoblastoma-like 1 (p107). (1064 aa)
	I3J9Z2_ORENI	Glycoprotein (transmembrane) nmb. (611 aa)
	LOC100706062	Si:ch211-137i24.10. (193 aa)
	LOC100705800	Si:ch211-137i24.10. (191 aa)
	prmt2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (443 aa)
	LOC100691373	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
	LOC100700935	ADAM metallopeptidase domain 17a. (851 aa)
	CPSF3	Cleavage and polyadenylation specific factor 3. (691 aa)
	id2	Inhibitor of DNA binding 2a. (136 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1386 aa)
	AIF1	Allograft inflammatory factor 1. (155 aa)
	LOC109194384	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (208 aa)
	kank2	KN motif and ankyrin repeat domains 2. (1027 aa)
	ino80	INO80 complex ATPase subunit. (1573 aa)
	ecd	Ecdysoneless homolog (Drosophila). (667 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPSF3	LOC100692710	ENSONIP00000004645	ENSONIP00000066919	Cleavage and polyadenylation specific factor 3.	Cleavage and polyadenylation specific factor 3.	0.900
CPSF3	LSM10	ENSONIP00000004645	ENSONIP00000026207	Cleavage and polyadenylation specific factor 3.	LSM10, U7 small nuclear RNA associated.	0.827
CPSF3	cdc73	ENSONIP00000004645	ENSONIP00000047370	Cleavage and polyadenylation specific factor 3.	Ro60, Y RNA binding protein.	0.435
CPSF3	lsm11	ENSONIP00000004645	ENSONIP00000022265	Cleavage and polyadenylation specific factor 3.	LSM11, U7 small nuclear RNA associated.	0.509
CTDSP1	ccnh	ENSONIP00000015564	ENSONIP00000039660	CTD small phosphatase 1.	Cyclin H; Belongs to the cyclin family.	0.472
CTDSP1	mnat1	ENSONIP00000015564	ENSONIP00000025341	CTD small phosphatase 1.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.462
Cul4b	I3KPB3_ORENI	ENSONIP00000030664	ENSONIP00000022958	Cullin-4B.	Autophagy/beclin-1 regulator 1b.	0.648
Cul4b	Sass6	ENSONIP00000030664	ENSONIP00000072723	Cullin-4B.	SAS-6 centriolar assembly protein.	0.467
Cul4b	ccnh	ENSONIP00000030664	ENSONIP00000039660	Cullin-4B.	Cyclin H; Belongs to the cyclin family.	0.670
Cul4b	cdc73	ENSONIP00000030664	ENSONIP00000047370	Cullin-4B.	Ro60, Y RNA binding protein.	0.502
Cul4b	cul4a	ENSONIP00000030664	ENSONIP00000076782	Cullin-4B.	Cullin 4A; Belongs to the cullin family.	0.919
Cul4b	dcun1d3	ENSONIP00000030664	ENSONIP00000025104	Cullin-4B.	DCN1-like protein.	0.677
Cul4b	ino80	ENSONIP00000030664	ENSONIP00000000976	Cullin-4B.	INO80 complex ATPase subunit.	0.497
Cul4b	mnat1	ENSONIP00000030664	ENSONIP00000025341	Cullin-4B.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.657
ENSONIP00000039288	ccnh	ENSONIP00000039288	ENSONIP00000039660	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase.	Cyclin H; Belongs to the cyclin family.	0.472
ENSONIP00000039288	mnat1	ENSONIP00000039288	ENSONIP00000025341	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.462
ENSONIP00000041766	ENSONIP00000064740	ENSONIP00000041766	ENSONIP00000064740	Cyclin-dependent kinase inhibitor 1B.	Cyclin-dependent kinase 4 inhibitor C isoform X2.	0.413
ENSONIP00000041766	LOC100691373	ENSONIP00000041766	ENSONIP00000005200	Cyclin-dependent kinase inhibitor 1B.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.884
ENSONIP00000041766	LOC100692495	ENSONIP00000041766	ENSONIP00000022971	Cyclin-dependent kinase inhibitor 1B.	Retinoblastoma-like 2 (p130).	0.643
ENSONIP00000041766	LOC100698323	ENSONIP00000041766	ENSONIP00000034856	Cyclin-dependent kinase inhibitor 1B.	Cyclin D2, a; Belongs to the cyclin family.	0.884