(32 nodes) HECT domain network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hecw1	Si:ch211-188f17.1. (1649 aa)
	LOC100701023	WW domain containing E3 ubiquitin protein ligase 1. (961 aa)
	UBE3A	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (896 aa)
	herc2	HECT and RLD domain containing E3 ubiquitin protein ligase 2. (4816 aa)
	trip12	Thyroid hormone receptor interactor 12. (2065 aa)
	ube3c	Ubiquitin protein ligase E3C. (1092 aa)
	I3JLD1_ORENI	Uncharacterized protein. (4087 aa)
	LOC100697163	E3 ubiquitin-protein ligase. (888 aa)
	herc4	HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1022 aa)
	HECTD4	HECT domain E3 ubiquitin protein ligase 4. (4451 aa)
	huwe1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4575 aa)
	AREL1	Apoptosis resistant E3 ubiquitin protein ligase 1. (1020 aa)
	hectd2	HECT domain containing 2. (762 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2785 aa)
	Hace1	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1. (925 aa)
	LOC100692390	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a. (1442 aa)
	herc3	HECT and RLD domain containing E3 ubiquitin protein ligase 3. (1048 aa)
	hectd3	HECT domain containing 3. (855 aa)
	I3KX51_ORENI	HECT domain-containing protein. (516 aa)
	hectd1	HECT domain containing 1. (2614 aa)
	Herc1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4909 aa)
	I3JEG4_ORENI	NEDD4 E3 ubiquitin protein ligase a. (960 aa)
	wwp2	E3 ubiquitin-protein ligase. (908 aa)
	I3J7B1_ORENI	Uncharacterized protein. (1389 aa)
	LOC100694718	E3 ubiquitin-protein ligase. (877 aa)
	LOC100691078	E3 ubiquitin-protein ligase. (844 aa)
	smurf1	E3 ubiquitin-protein ligase. (745 aa)
	LOC100696261	Ubiquitin protein ligase E3A. (874 aa)
	SMURF2	E3 ubiquitin-protein ligase. (747 aa)
	nedd4l	NEDD4 like E3 ubiquitin protein ligase. (1289 aa)
	ube3b	Ubiquitin protein ligase E3B. (1068 aa)
	g2e3	G2/M-phase specific E3 ubiquitin protein ligase. (769 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AREL1	trip12	ENSONIP00000015134	ENSONIP00000007095	Apoptosis resistant E3 ubiquitin protein ligase 1.	Thyroid hormone receptor interactor 12.	0.794
HECTD4	trip12	ENSONIP00000013423	ENSONIP00000007095	HECT domain E3 ubiquitin protein ligase 4.	Thyroid hormone receptor interactor 12.	0.413
Hace1	trip12	ENSONIP00000020791	ENSONIP00000007095	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1.	Thyroid hormone receptor interactor 12.	0.794
Hace1	ube3c	ENSONIP00000020791	ENSONIP00000007518	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1.	Ubiquitin protein ligase E3C.	0.401
Herc1	LOC100696261	ENSONIP00000033525	ENSONIP00000068650	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Ubiquitin protein ligase E3A.	0.462
Herc1	UBE3A	ENSONIP00000033525	ENSONIP00000004712	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.581
Herc1	trip12	ENSONIP00000033525	ENSONIP00000007095	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Thyroid hormone receptor interactor 12.	0.435
I3J7B1_ORENI	trip12	ENSONIP00000047377	ENSONIP00000007095	Uncharacterized protein.	Thyroid hormone receptor interactor 12.	0.409
I3JEG4_ORENI	trip12	ENSONIP00000035704	ENSONIP00000007095	NEDD4 E3 ubiquitin protein ligase a.	Thyroid hormone receptor interactor 12.	0.409
I3JLD1_ORENI	LOC100696261	ENSONIP00000009675	ENSONIP00000068650	Uncharacterized protein.	Ubiquitin protein ligase E3A.	0.462
I3JLD1_ORENI	UBE3A	ENSONIP00000009675	ENSONIP00000004712	Uncharacterized protein.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.581
I3JLD1_ORENI	trip12	ENSONIP00000009675	ENSONIP00000007095	Uncharacterized protein.	Thyroid hormone receptor interactor 12.	0.435
LOC100691078	SMURF2	ENSONIP00000062937	ENSONIP00000069637	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.900
LOC100691078	trip12	ENSONIP00000062937	ENSONIP00000007095	E3 ubiquitin-protein ligase.	Thyroid hormone receptor interactor 12.	0.409
LOC100692390	trip12	ENSONIP00000021149	ENSONIP00000007095	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a.	Thyroid hormone receptor interactor 12.	0.409
LOC100694718	LOC100697163	ENSONIP00000056551	ENSONIP00000011573	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.901
LOC100694718	LOC100701023	ENSONIP00000056551	ENSONIP00000004518	E3 ubiquitin-protein ligase.	WW domain containing E3 ubiquitin protein ligase 1.	0.663
LOC100694718	trip12	ENSONIP00000056551	ENSONIP00000007095	E3 ubiquitin-protein ligase.	Thyroid hormone receptor interactor 12.	0.409
LOC100694718	wwp2	ENSONIP00000056551	ENSONIP00000041467	E3 ubiquitin-protein ligase.	E3 ubiquitin-protein ligase.	0.666
LOC100696261	Herc1	ENSONIP00000068650	ENSONIP00000033525	Ubiquitin protein ligase E3A.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.462