(20 nodes) CBS domain network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Clcn6	Chloride channel 6; Belongs to the chloride channel (TC 2.A.49) family. (827 aa)
	clcn4	Chloride channel protein. (794 aa)
	impdh2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (565 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (427 aa)
	clcn3	Chloride channel protein. (881 aa)
	Cnnm3	Uncharacterized protein. (764 aa)
	I3KLA6_ORENI	Uncharacterized protein. (780 aa)
	LOC100701529	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (625 aa)
	LOC100697765	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (379 aa)
	LOC100693341	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (611 aa)
	LOC100707713	Uncharacterized protein. (815 aa)
	I3JZ42_ORENI	Cyclin and CBS domain divalent metal cation transport mediator 4a. (820 aa)
	I3JTS5_ORENI	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (520 aa)
	cnnm2	Cyclin and CBS domain divalent metal cation transport mediator 2b. (851 aa)
	CNNM1-2	Cyclin and CBS domain divalent metal cation transport mediator 1. (892 aa)
	LOC100703206	Uncharacterized protein. (312 aa)
	clcn7	Chloride channel protein. (799 aa)
	clcn5	Chloride channel protein. (840 aa)
	LOC100707752	Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (592 aa)
	CNNM1	Cyclin and CBS domain divalent metal cation transport mediator 1. (892 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3JTS5_ORENI	I3KLA6_ORENI	ENSONIP00000027328	ENSONIP00000062938	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	Uncharacterized protein.	0.902
I3JTS5_ORENI	LOC100697765	ENSONIP00000027328	ENSONIP00000058577	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	0.915
I3JTS5_ORENI	prkag1	ENSONIP00000027328	ENSONIP00000072597	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	0.918
I3KLA6_ORENI	I3JTS5_ORENI	ENSONIP00000062938	ENSONIP00000027328	Uncharacterized protein.	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	0.902
I3KLA6_ORENI	LOC100697765	ENSONIP00000062938	ENSONIP00000058577	Uncharacterized protein.	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	0.915
I3KLA6_ORENI	prkag1	ENSONIP00000062938	ENSONIP00000072597	Uncharacterized protein.	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	0.918
LOC100693341	LOC100701529	ENSONIP00000050245	ENSONIP00000058675	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.900
LOC100693341	impdh2	ENSONIP00000050245	ENSONIP00000073439	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.938
LOC100697765	I3JTS5_ORENI	ENSONIP00000058577	ENSONIP00000027328	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	0.915
LOC100697765	I3KLA6_ORENI	ENSONIP00000058577	ENSONIP00000062938	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	Uncharacterized protein.	0.915
LOC100697765	prkag1	ENSONIP00000058577	ENSONIP00000072597	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	0.920
LOC100701529	LOC100693341	ENSONIP00000058675	ENSONIP00000050245	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.900
LOC100701529	impdh2	ENSONIP00000058675	ENSONIP00000073439	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.938
impdh2	LOC100693341	ENSONIP00000073439	ENSONIP00000050245	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.938
impdh2	LOC100701529	ENSONIP00000073439	ENSONIP00000058675	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.938
prkag1	I3JTS5_ORENI	ENSONIP00000072597	ENSONIP00000027328	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b.	0.918
prkag1	I3KLA6_ORENI	ENSONIP00000072597	ENSONIP00000062938	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	Uncharacterized protein.	0.918
prkag1	LOC100697765	ENSONIP00000072597	ENSONIP00000058577	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit.	Protein kinase, AMP-activated, gamma 3a non-catalytic subunit.	0.920