(23 nodes) Toll/interleukin-1 receptor homology (TIR) domain superfamily network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102076024	TIR domain-containing protein; Belongs to the Toll-like receptor family. (827 aa)
	BANK1	B cell scaffold protein with ankyrin repeats 1. (679 aa)
	LOC100696189	Toll-like receptor 9; Belongs to the Toll-like receptor family. (1078 aa)
	LOC100693228	Uncharacterized protein. (715 aa)
	pik3ap1	Phosphoinositide-3-kinase adaptor protein 1. (863 aa)
	LOC100703629	Toll-like receptor 3; Belongs to the Toll-like receptor family. (912 aa)
	sarm1	Sterile alpha and TIR motif containing 1. (725 aa)
	LOC100708279	Interleukin 1 receptor accessory protein-like 1a. (681 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (291 aa)
	I3J7X5_ORENI	TIR domain-containing protein; Belongs to the Toll-like receptor family. (576 aa)
	il1rap	Uncharacterized protein. (612 aa)
	LOC100702929	Zmp:0000000936. (639 aa)
	LOC100705953	Toll-like receptor 18. (889 aa)
	tlr2	TIR domain-containing protein. (821 aa)
	LOC102075875	Uncharacterized protein. (530 aa)
	LOC100702389	TIR domain-containing protein. (565 aa)
	LOC100692776	Toll-like receptor 22. (961 aa)
	TLR5	Toll like receptor 5; Belongs to the Toll-like receptor family. (884 aa)
	tlr7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1053 aa)
	TLR2	Uncharacterized protein. (787 aa)
	LOC100702660	Uncharacterized protein. (554 aa)
	I3KFT0_ORENI	Interleukin 1 receptor accessory protein-like 2. (704 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3J7X5_ORENI	myd88	ENSONIP00000004965	ENSONIP00000007350	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.657
LOC100692776	myd88	ENSONIP00000042046	ENSONIP00000007350	Toll-like receptor 22.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.787
LOC100692776	tirap	ENSONIP00000042046	ENSONIP00000006704	Toll-like receptor 22.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.514
LOC100696189	myd88	ENSONIP00000015638	ENSONIP00000007350	Toll-like receptor 9; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.982
LOC100696189	pik3ap1	ENSONIP00000015638	ENSONIP00000012992	Toll-like receptor 9; Belongs to the Toll-like receptor family.	Phosphoinositide-3-kinase adaptor protein 1.	0.449
LOC100696189	tirap	ENSONIP00000015638	ENSONIP00000006704	Toll-like receptor 9; Belongs to the Toll-like receptor family.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.498
LOC100702389	il1rap	ENSONIP00000048247	ENSONIP00000001486	TIR domain-containing protein.	Uncharacterized protein.	0.973
LOC100702389	myd88	ENSONIP00000048247	ENSONIP00000007350	TIR domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.812
LOC100702660	LOC102075875	ENSONIP00000021433	ENSONIP00000047429	Uncharacterized protein.	Uncharacterized protein.	0.909
LOC100702660	il1rap	ENSONIP00000021433	ENSONIP00000001486	Uncharacterized protein.	Uncharacterized protein.	0.993
LOC100702660	myd88	ENSONIP00000021433	ENSONIP00000007350	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.986
LOC100702929	il1rap	ENSONIP00000056860	ENSONIP00000001486	Zmp:0000000936.	Uncharacterized protein.	0.937
LOC100702929	myd88	ENSONIP00000056860	ENSONIP00000007350	Zmp:0000000936.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.871
LOC100703629	myd88	ENSONIP00000012793	ENSONIP00000007350	Toll-like receptor 3; Belongs to the Toll-like receptor family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.940
LOC100703629	tirap	ENSONIP00000012793	ENSONIP00000006704	Toll-like receptor 3; Belongs to the Toll-like receptor family.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.602
LOC100705953	LOC102076024	ENSONIP00000075939	ENSONIP00000017788	Toll-like receptor 18.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.900
LOC100705953	myd88	ENSONIP00000075939	ENSONIP00000007350	Toll-like receptor 18.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.968
LOC100705953	tirap	ENSONIP00000075939	ENSONIP00000006704	Toll-like receptor 18.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.933
LOC102075875	LOC100702660	ENSONIP00000047429	ENSONIP00000021433	Uncharacterized protein.	Uncharacterized protein.	0.909
LOC102075875	il1rap	ENSONIP00000047429	ENSONIP00000001486	Uncharacterized protein.	Uncharacterized protein.	0.924