STRINGSTRING
ntmt1 ntmt1 LOC100699470 LOC100699470 dimt1 dimt1 setd3 setd3 dnmt1 dnmt1 I3JAV9_ORENI I3JAV9_ORENI LOC100698471 LOC100698471 TRMT5 TRMT5 LOC100702922 LOC100702922 lcmt1 lcmt1 LOC100707110 LOC100707110 mettl1 mettl1 LOC100691285 LOC100691285 icmt icmt tfb2m tfb2m rrp8 rrp8 LOC100696323 LOC100696323 LOC100711761 LOC100711761 pnmt pnmt prmt5 prmt5 rnmt rnmt Kmt5b Kmt5b I3KC42_ORENI I3KC42_ORENI LOC100710512 LOC100710512 I3KAI1_ORENI I3KAI1_ORENI LOC100692647 LOC100692647 Nop2 Nop2 kmt2d kmt2d suv39h1 suv39h1 setd7 setd7 coq5 coq5 nsun4 nsun4 PRMT8 PRMT8 Prmt9 Prmt9 I3JTS7_ORENI I3JTS7_ORENI I3JR99_ORENI I3JR99_ORENI bmt2 bmt2 gnmt gnmt tfb1m tfb1m mettl11b mettl11b dph5 dph5 nsun2 nsun2 mtr mtr Prmt3 Prmt3 bcdin3d bcdin3d setdb1 setdb1 Carm1 Carm1 KMT2A KMT2A nsun6 nsun6 cmtr2 cmtr2 Pcmt1 Pcmt1 dph2 dph2 asmt asmt prmt2 prmt2 setd2 setd2 kmt2b kmt2b trmt12 trmt12 rsad1 rsad1 Nsun5 Nsun5 ftsj3 ftsj3 EEF1AKMT2 EEF1AKMT2 COQ3 COQ3 trmt1 trmt1 Trmt2a Trmt2a prdm12 prdm12 Amd1 Amd1 prmt1 prmt1 LOC100691614 LOC100691614 LOC100690123 LOC100690123 elp3 elp3 mrm2 mrm2 I3JRJ0_ORENI I3JRJ0_ORENI nsun3 nsun3 mettl16 mettl16 trmt61a trmt61a I3K397_ORENI I3K397_ORENI pemt pemt lias lias LOC100693331 LOC100693331 Dph1 Dph1 asmtl asmtl LOC100692897 LOC100692897 gamt gamt LOC100705938 LOC100705938 LOC100692734 LOC100692734 dot1l dot1l kmt5a kmt5a setd6 setd6 LOC100702269 LOC100702269 trmt1l trmt1l prmt7 prmt7
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ntmt1N-terminal Xaa-Pro-Lys N-methyltransferase 1. (275 aa)
LOC100699470NOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (1200 aa)
dimt1rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (309 aa)
setd3Protein-histidine N-methyltransferase. (657 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1510 aa)
I3JAV9_ORENIProtein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (315 aa)
LOC100698471SET domain and mariner transposase fusion gene. (317 aa)
TRMT5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (523 aa)
LOC100702922Protein-L-isoaspartate O-methyltransferase. (249 aa)
lcmt1Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (325 aa)
LOC100707110Ash1 (absent, small, or homeotic)-like (Drosophila). (2966 aa)
mettl1tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (244 aa)
LOC100691285tRNA methyltransferase 2 homolog B; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (538 aa)
icmtProtein-S-isoprenylcysteine O-methyltransferase. (291 aa)
tfb2mrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (453 aa)
rrp8Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (539 aa)
LOC100696323DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1475 aa)
LOC100711761CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (495 aa)
pnmtPhenylethanolamine N-methyltransferase. (274 aa)
prmt5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (635 aa)
rnmtmRNA cap guanine-N7 methyltransferase. (381 aa)
Kmt5bLysine methyltransferase 5B. (865 aa)
I3KC42_ORENIDNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (784 aa)
LOC100710512DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1623 aa)
I3KAI1_ORENINuclear receptor binding SET domain protein 3. (1446 aa)
LOC100692647SET domain containing 1B, histone lysine methyltransferase a. (1811 aa)
Nop2NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (587 aa)
kmt2dLysine (K)-specific methyltransferase 2D. (5041 aa)
suv39h1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (411 aa)
setd7SET domain containing 7, histone lysine methyltransferase. (361 aa)
coq52-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (321 aa)
nsun4NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (392 aa)
PRMT8Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (412 aa)
Prmt9Protein arginine methyltransferase 9; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (868 aa)
I3JTS7_ORENILysine (K)-specific methyltransferase 2Cb. (417 aa)
I3JR99_ORENINOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (596 aa)
bmt2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (392 aa)
gnmtGlycine N-methyltransferase. (295 aa)
tfb1mrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (358 aa)
mettl11bMethyltransferase like 11B. (292 aa)
dph5Diphthamide biosynthesis 5. (288 aa)
nsun2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (775 aa)
mtrMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1269 aa)
Prmt3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (526 aa)
bcdin3dBCDIN3 domain containing. (247 aa)
setdb1SET domain bifurcated histone lysine methyltransferase 1b. (1230 aa)
Carm1Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (605 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4124 aa)
nsun6NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (462 aa)
cmtr2Cap methyltransferase 2. (770 aa)
Pcmt1Protein-L-isoaspartate O-methyltransferase. (270 aa)
dph22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (494 aa)
asmtAcetylserotonin O-methyltransferase. (358 aa)
prmt2Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (443 aa)
setd2SET domain containing 2, histone lysine methyltransferase. (2602 aa)
kmt2bLysine (K)-specific methyltransferase 2Bb. (3861 aa)
trmt12tRNA methyltransferase 12 homolog. (409 aa)
rsad1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
Nsun5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (482 aa)
ftsj3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (858 aa)
EEF1AKMT2EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family. (239 aa)
COQ3Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (328 aa)
trmt1tRNA (guanine(26)-N(2))-dimethyltransferase. (676 aa)
Trmt2atRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (611 aa)
prdm12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (389 aa)
Amd1S-adenosylmethionine decarboxylase proenzyme. (338 aa)
prmt1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (434 aa)
LOC100691614Lysine methyltransferase 5C. (2039 aa)
LOC100690123Methylphosphate capping enzyme. (753 aa)
elp3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (575 aa)
mrm2Mitochondrial rRNA methyltransferase 2. (239 aa)
I3JRJ0_ORENIBin3-type SAM domain-containing protein. (429 aa)
nsun3NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (464 aa)
mettl16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (590 aa)
trmt61atRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. (296 aa)
I3K397_ORENINuclear receptor binding SET domain protein 2. (1109 aa)
pemtPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (239 aa)
liasLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (423 aa)
LOC100693331DNA (cytosine-5-)-methyltransferase 3 alpha b; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (929 aa)
Dph12-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (427 aa)
asmtlAcetylserotonin O-methyltransferase-like. (662 aa)
LOC100692897Acetylserotonin O-methyltransferase 2. (350 aa)
gamtGuanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (235 aa)
LOC100705938Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (411 aa)
LOC100692734Nuclear receptor binding SET domain protein 1a. (2550 aa)
dot1lHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1610 aa)
kmt5aLysine methyltransferase 5Aa. (333 aa)
setd6N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (460 aa)
LOC100702269DNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (829 aa)
trmt1ltRNA methyltransferase 1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (731 aa)
prmt7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (697 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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