37 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
	rpa3	Replication protein A3. (122 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (819 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (500 aa)
	oxtr	RAD18 E3 ubiquitin protein ligase. (497 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	LOC100697269	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
	ENSONIP00000002713	annotation not available (760 aa)
	LOC100708142	SCY domain-containing protein. (126 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)
	dtl	Denticleless E3 ubiquitin protein ligase homolog (Drosophila). (661 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (830 aa)
	rfc1	Replication factor C subunit 1. (1169 aa)
	rfc5	Replication factor C (activator 1) 5. (341 aa)
	LOC100701531	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
	rfc2	Replication factor C (activator 1) 2. (361 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
	wdr48	WD repeat domain 48b. (690 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	rpa2	Replication protein A2. (278 aa)
	LOC102079736	Uncharacterized protein. (966 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	Pold1	DNA polymerase. (1105 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
	Cul4b	Cullin-4B. (869 aa)
	pold4	DNA polymerase delta subunit 4. (107 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (571 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cul4b	ENSONIP00000002713	ENSONIP00000030664	ENSONIP00000002713	Cullin-4B.	annotation not available	0.525
Cul4b	ENSONIP00000047919	ENSONIP00000030664	ENSONIP00000047919	Cullin-4B.	Ubiquitin B.	0.716
Cul4b	LOC100708142	ENSONIP00000030664	ENSONIP00000002941	Cullin-4B.	SCY domain-containing protein.	0.539
Cul4b	LOC102079736	ENSONIP00000030664	ENSONIP00000022806	Cullin-4B.	Uncharacterized protein.	0.525
Cul4b	Pold1	ENSONIP00000030664	ENSONIP00000024391	Cullin-4B.	DNA polymerase.	0.633
Cul4b	RPA1	ENSONIP00000030664	ENSONIP00000027967	Cullin-4B.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.463
Cul4b	cul4a	ENSONIP00000030664	ENSONIP00000076782	Cullin-4B.	Cullin 4A; Belongs to the cullin family.	0.919
Cul4b	ddb1	ENSONIP00000030664	ENSONIP00000071715	Cullin-4B.	Damage-specific DNA binding protein 1.	0.988
Cul4b	dtl	ENSONIP00000030664	ENSONIP00000007591	Cullin-4B.	Denticleless E3 ubiquitin protein ligase homolog (Drosophila).	0.948
Cul4b	meiob	ENSONIP00000030664	ENSONIP00000024921	Cullin-4B.	Methionine sulfoxide reductase B1b.	0.407
Cul4b	oxtr	ENSONIP00000030664	ENSONIP00000073825	Cullin-4B.	RAD18 E3 ubiquitin protein ligase.	0.679
Cul4b	pcna	ENSONIP00000030664	ENSONIP00000070559	Cullin-4B.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.699
Cul4b	pold2	ENSONIP00000030664	ENSONIP00000075122	Cullin-4B.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.612
Cul4b	pole	ENSONIP00000030664	ENSONIP00000017005	Cullin-4B.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.669
Cul4b	pole2	ENSONIP00000030664	ENSONIP00000081592	Cullin-4B.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.636
Cul4b	pole4	ENSONIP00000030664	ENSONIP00000002942	Cullin-4B.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.621
Cul4b	rbx1	ENSONIP00000030664	ENSONIP00000010640	Cullin-4B.	Ring-box 1, E3 ubiquitin protein ligase.	0.969
Cul4b	rfc1	ENSONIP00000030664	ENSONIP00000011300	Cullin-4B.	Replication factor C subunit 1.	0.647
Cul4b	rfc2	ENSONIP00000030664	ENSONIP00000018572	Cullin-4B.	Replication factor C (activator 1) 2.	0.636
Cul4b	rfc3	ENSONIP00000030664	ENSONIP00000015916	Cullin-4B.	Replication factor C (activator 1) 3.	0.626