(30 nodes) Translesion Synthesis by POLH network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	I3IUX9_ORENI	Polymerase (DNA directed), eta. (640 aa)
	LOC100701531	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	rfc5	Replication factor C (activator 1) 5. (341 aa)
	rfc1	Replication factor C subunit 1. (1169 aa)
	sprtn	SprT-like N-terminal domain. (499 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (571 aa)
	ENSONIP00000002713	annotation not available (760 aa)
	rpa3	Replication protein A3. (122 aa)
	LOC100702196	Zgc:136908; Belongs to the AAA ATPase family. (826 aa)
	SPATA5	Spermatogenesis associated 5. (900 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	LOC100697269	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
	vcp	Valosin containing protein; Belongs to the AAA ATPase family. (816 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	LOC102079736	Uncharacterized protein. (966 aa)
	nploc4	NPL4 homolog, ubiquitin recognition factor. (624 aa)
	rpa2	Replication protein A2. (278 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	Rchy1	Ring finger and CHY zinc finger domain containing 1. (262 aa)
	LOC100709230	Si:dkey-24l11.2. (632 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	rfc2	Replication factor C (activator 1) 2. (361 aa)
	ufd1	Ubiquitin recognition factor in ER associated degradation 1. (310 aa)
	spata5l1	Spermatogenesis associated 5-like 1. (748 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000002713	I3IUX9_ORENI	ENSONIP00000002713	ENSONIP00000000419	annotation not available	Polymerase (DNA directed), eta.	0.633
ENSONIP00000002713	LOC100702196	ENSONIP00000002713	ENSONIP00000075385	annotation not available	Zgc:136908; Belongs to the AAA ATPase family.	0.473
ENSONIP00000002713	RPA1	ENSONIP00000002713	ENSONIP00000027967	annotation not available	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.711
ENSONIP00000002713	SPATA5	ENSONIP00000002713	ENSONIP00000071571	annotation not available	Spermatogenesis associated 5.	0.473
ENSONIP00000002713	meiob	ENSONIP00000002713	ENSONIP00000024921	annotation not available	Methionine sulfoxide reductase B1b.	0.711
ENSONIP00000002713	pcna	ENSONIP00000002713	ENSONIP00000070559	annotation not available	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.965
ENSONIP00000002713	rfc1	ENSONIP00000002713	ENSONIP00000011300	annotation not available	Replication factor C subunit 1.	0.572
ENSONIP00000002713	rfc2	ENSONIP00000002713	ENSONIP00000018572	annotation not available	Replication factor C (activator 1) 2.	0.971
ENSONIP00000002713	rfc3	ENSONIP00000002713	ENSONIP00000015916	annotation not available	Replication factor C (activator 1) 3.	0.977
ENSONIP00000002713	rfc4	ENSONIP00000002713	ENSONIP00000024158	annotation not available	Replication factor C (activator 1) 4.	0.971
ENSONIP00000002713	rfc5	ENSONIP00000002713	ENSONIP00000013302	annotation not available	Replication factor C (activator 1) 5.	0.971
ENSONIP00000002713	rpa1	ENSONIP00000002713	ENSONIP00000069956	annotation not available	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.711
ENSONIP00000002713	rpa2	ENSONIP00000002713	ENSONIP00000020396	annotation not available	Replication protein A2.	0.566
ENSONIP00000002713	rpa3	ENSONIP00000002713	ENSONIP00000077053	annotation not available	Replication protein A3.	0.594
ENSONIP00000002713	rps27a	ENSONIP00000002713	ENSONIP00000020250	annotation not available	Ribosomal protein S27a.	0.595
ENSONIP00000002713	spata5l1	ENSONIP00000002713	ENSONIP00000016753	annotation not available	Spermatogenesis associated 5-like 1.	0.473
ENSONIP00000002713	sprtn	ENSONIP00000002713	ENSONIP00000023055	annotation not available	SprT-like N-terminal domain.	0.702
ENSONIP00000002713	ufd1	ENSONIP00000002713	ENSONIP00000018099	annotation not available	Ubiquitin recognition factor in ER associated degradation 1.	0.612
ENSONIP00000002713	vcp	ENSONIP00000002713	ENSONIP00000048463	annotation not available	Valosin containing protein; Belongs to the AAA ATPase family.	0.473
ENSONIP00000047919	I3IUX9_ORENI	ENSONIP00000047919	ENSONIP00000000419	Ubiquitin B.	Polymerase (DNA directed), eta.	0.940