55 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100697238	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (486 aa)
	egf	Epidermal growth factor. (1169 aa)
	LOC100700666	ArfGAP with dual PH domains 2. (378 aa)
	LOC100701023	WW domain containing E3 ubiquitin protein ligase 1. (961 aa)
	LOC100709873	Receptor protein-tyrosine kinase. (1374 aa)
	LOC100711745	Neuregulin 2a. (747 aa)
	yap1	Yes-associated protein 1. (455 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	gng10	Betacellulin, epidermal growth factor family member. (185 aa)
	LOC100694113	Crystallin, beta B1, like 3; Belongs to the beta/gamma-crystallin family. (209 aa)
	LOC100697163	E3 ubiquitin-protein ligase. (888 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
	I3K0I9_ORENI	Neuregulin 1. (649 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	nrg4	EGF-like domain-containing protein. (109 aa)
	LOC100698076	Neuregulin 2b. (726 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	mxd4	MAX dimerization protein 4. (210 aa)
	LOC100707861	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ADAP2	ArfGAP with dual PH domains 2. (384 aa)
	LOC100693401	Uncharacterized protein. (380 aa)
	LOC102077535	Pro-neuregulin-3, membrane-bound isoform. (678 aa)
	LOC100710620	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (460 aa)
	ENSONIP00000029870	annotation not available (570 aa)
	LOC100707819	Erb-b2 receptor tyrosine kinase 3b. (1374 aa)
	LOC100690945	Signal transducer and activator of transcription. (802 aa)
	I3JJI6_ORENI	DDE_Tnp_1_7 domain-containing protein. (510 aa)
	NCSTN	Nicastrin. (697 aa)
	I3JEG4_ORENI	NEDD4 E3 ubiquitin protein ligase a. (960 aa)
	LOC100707756	Uncharacterized protein. (382 aa)
	LOC100709722	EGF-like domain-containing protein. (133 aa)
	ENSONIP00000039289	annotation not available (471 aa)
	LOC100692331	Signal transducer and activator of transcription. (803 aa)
	LOC100706837	ArfGAP with dual PH domains 1. (377 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	wwox	WW domain containing oxidoreductase. (478 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (873 aa)
	LOC100699012	Fibronectin type III domain containing 3Ba. (1174 aa)
	I3KS89_ORENI	Protein kinase domain-containing protein. (1325 aa)
	LOC100694718	E3 ubiquitin-protein ligase. (877 aa)
	LOC100704479	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1072 aa)
	SHC4	SHC adaptor protein 4. (349 aa)
	LOC100692677	Tyrosine-protein kinase. (593 aa)
	LOC102080562	Pro-neuregulin-3, membrane-bound isoform isoform X2. (718 aa)
	grb2	Growth factor receptor-bound protein 2b. (222 aa)
	LOC100703836	Zgc:55558. (250 aa)
	aph1a	APH1B gamma secretase subunit. (258 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (615 aa)
	LOC100701577	Receptor protein-tyrosine kinase. (1408 aa)
	ENSONIP00000074581	PiggyBac transposable element-derived protein 4. (431 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1239 aa)
	ENSONIP00000078138	PiggyBac transposable element-derived protein 4. (371 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSONIP00000029870	ENSONIP00000052211	ENSONIP00000029870	Cold shock domain containing E1, RNA-binding.	annotation not available	0.458
CSDE1	ENSONIP00000047919	ENSONIP00000052211	ENSONIP00000047919	Cold shock domain containing E1, RNA-binding.	Ubiquitin B.	0.488
CSDE1	I3KS89_ORENI	ENSONIP00000052211	ENSONIP00000055115	Cold shock domain containing E1, RNA-binding.	Protein kinase domain-containing protein.	0.458
CSDE1	LOC100692677	ENSONIP00000052211	ENSONIP00000059722	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.404
CSDE1	LOC100701577	ENSONIP00000052211	ENSONIP00000073007	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.458
CSDE1	LOC100704479	ENSONIP00000052211	ENSONIP00000058182	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.508
CSDE1	LOC100707819	ENSONIP00000052211	ENSONIP00000029882	Cold shock domain containing E1, RNA-binding.	Erb-b2 receptor tyrosine kinase 3b.	0.458
CSDE1	LOC100707861	ENSONIP00000052211	ENSONIP00000022585	Cold shock domain containing E1, RNA-binding.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.508
CSDE1	LOC100709722	ENSONIP00000052211	ENSONIP00000039207	Cold shock domain containing E1, RNA-binding.	EGF-like domain-containing protein.	0.441
CSDE1	LOC100709873	ENSONIP00000052211	ENSONIP00000005301	Cold shock domain containing E1, RNA-binding.	Receptor protein-tyrosine kinase.	0.458
CSDE1	PIK3CA	ENSONIP00000052211	ENSONIP00000013444	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.508
CSDE1	SHC4	ENSONIP00000052211	ENSONIP00000058468	Cold shock domain containing E1, RNA-binding.	SHC adaptor protein 4.	0.416
CSDE1	SRC	ENSONIP00000052211	ENSONIP00000008685	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.404
CSDE1	egf	ENSONIP00000052211	ENSONIP00000001408	Cold shock domain containing E1, RNA-binding.	Epidermal growth factor.	0.504
CSDE1	gng10	ENSONIP00000052211	ENSONIP00000009591	Cold shock domain containing E1, RNA-binding.	Betacellulin, epidermal growth factor family member.	0.444
CSDE1	grb2	ENSONIP00000052211	ENSONIP00000064237	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.639
CSDE1	rps27a	ENSONIP00000052211	ENSONIP00000020250	Cold shock domain containing E1, RNA-binding.	Ribosomal protein S27a.	0.479
CSDE1	shc1	ENSONIP00000052211	ENSONIP00000007937	Cold shock domain containing E1, RNA-binding.	SHC (Src homology 2 domain containing) transforming protein 1.	0.416
CSDE1	uba52	ENSONIP00000052211	ENSONIP00000016035	Cold shock domain containing E1, RNA-binding.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.475
ENSONIP00000029870	CSDE1	ENSONIP00000029870	ENSONIP00000052211	annotation not available	Cold shock domain containing E1, RNA-binding.	0.458