(56 nodes) Gamma carboxylation, hypusine formation and arylsulfatase activation network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	dph5	Diphthamide biosynthesis 5. (288 aa)
	dohh	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family. (305 aa)
	arsj	Arylsulfatase family, member J. (566 aa)
	dph2	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (494 aa)
	LOC100696527	Arylsulfatase family, member Ia. (570 aa)
	LOC100704957	Coagulation factor IXa. (530 aa)
	LOC100691075	Fructosamine 3 kinase related protein; Belongs to the fructosamine kinase family. (309 aa)
	dph6	Diphthamine biosynthesis 6. (708 aa)
	gas6	Uncharacterized protein. (662 aa)
	ENSONIP00000081123	Coagulation factor VII, like. (420 aa)
	LOC100695221	Gla domain-containing protein. (198 aa)
	LOC100703931	Coagulation factor VII. (448 aa)
	bglap	Gla domain-containing protein. (97 aa)
	ENSONIP00000075796	Coagulation factor X. (433 aa)
	LOC100698730	Arylsulfatase A. (499 aa)
	LOC100700322	Protein Z, vitamin K-dependent plasma glycoprotein a; Belongs to the peptidase S1 family. (420 aa)
	Dhps	Deoxyhypusine synthase. (367 aa)
	I3IXF6_ORENI	Si:dkey-174i8.1. (429 aa)
	ENSONIP00000069223	Coagulation factor VII. (447 aa)
	ENSONIP00000068171	annotation not available (103 aa)
	ggcx	Gamma-glutamyl carboxylase. (795 aa)
	LOC100700271	Eukaryotic translation initiation factor 5A. (153 aa)
	I3JZ45_ORENI	SEC14-like lipid binding 7. (394 aa)
	dnajc24	Uncharacterized protein. (173 aa)
	pros1	Protein S. (679 aa)
	LOC100702313	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (658 aa)
	LOC100702471	Tr-type G domain-containing protein. (858 aa)
	sumf2	Inactive C-alpha-formylglycine-generating enzyme 2 isoform X1. (308 aa)
	sumf1	Sulfatase modifying factor 1. (387 aa)
	furin	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (843 aa)
	LOC100705046	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (812 aa)
	Dph1	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (427 aa)
	Sts	Steroid sulfatase (microsomal), isozyme S. (581 aa)
	I3JWG4_ORENI	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (484 aa)
	arsk	Arylsulfatase family, member K. (551 aa)
	SEC14L1	SEC14 like lipid binding 1. (750 aa)
	ARSB	Arylsulfatase B. (525 aa)
	ENSONIP00000044867	LOW QUALITY PROTEIN: coagulation factor VII-like. (167 aa)
	LOC100699661	Sulfatase domain-containing protein. (765 aa)
	eef2	Eukaryotic translation elongation factor 2b. (875 aa)
	LOC100690740	Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family. (361 aa)
	EIF5AL1	Eukaryotic translation initiation factor 5A. (155 aa)
	sec14l2	SEC14-like lipid binding 8. (531 aa)
	LOC100706381	Arylsulfatase H. (604 aa)
	arsg	Arylsulfatase G. (539 aa)
	LOC100700129	SEC14-like lipid binding 1. (700 aa)
	LOC100702351	Diphthamide biosynthesis 3. (83 aa)
	LOC100700156	Eukaryotic translation initiation factor 5A. (157 aa)
	icmt	Protein-S-isoprenylcysteine O-methyltransferase. (291 aa)
	I3KKX7_ORENI	Uncharacterized protein. (473 aa)
	proc	Uncharacterized protein. (442 aa)
	dph7	Diphthamide biosynthesis 7. (442 aa)
	LOC100704738	Uncharacterized protein; Belongs to the peptidase S1 family. (430 aa)
	LOC106096476	Coagulation factor X. (500 aa)
	LOC100703116	Vitamin K-dependent protein Z. (554 aa)
	LOC100710669	Coagulation factor IXb. (529 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARSB	LOC100698730	ENSONIP00000045768	ENSONIP00000072166	Arylsulfatase B.	Arylsulfatase A.	0.959
ARSB	LOC100706381	ENSONIP00000045768	ENSONIP00000032783	Arylsulfatase B.	Arylsulfatase H.	0.547
ARSB	Sts	ENSONIP00000045768	ENSONIP00000050612	Arylsulfatase B.	Steroid sulfatase (microsomal), isozyme S.	0.540
ARSB	arsg	ENSONIP00000045768	ENSONIP00000025013	Arylsulfatase B.	Arylsulfatase G.	0.960
ARSB	arsk	ENSONIP00000045768	ENSONIP00000046508	Arylsulfatase B.	Arylsulfatase family, member K.	0.674
ARSB	sumf1	ENSONIP00000045768	ENSONIP00000052317	Arylsulfatase B.	Sulfatase modifying factor 1.	0.702
ARSB	sumf2	ENSONIP00000045768	ENSONIP00000052784	Arylsulfatase B.	Inactive C-alpha-formylglycine-generating enzyme 2 isoform X1.	0.626
Dhps	EIF5AL1	ENSONIP00000070653	ENSONIP00000037349	Deoxyhypusine synthase.	Eukaryotic translation initiation factor 5A.	0.950
Dhps	LOC100700156	ENSONIP00000070653	ENSONIP00000023864	Deoxyhypusine synthase.	Eukaryotic translation initiation factor 5A.	0.950
Dhps	LOC100700271	ENSONIP00000070653	ENSONIP00000062490	Deoxyhypusine synthase.	Eukaryotic translation initiation factor 5A.	0.950
Dhps	dohh	ENSONIP00000070653	ENSONIP00000009699	Deoxyhypusine synthase.	Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family.	0.964
Dph1	LOC100702351	ENSONIP00000051673	ENSONIP00000024132	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	Diphthamide biosynthesis 3.	0.993
Dph1	LOC100702471	ENSONIP00000051673	ENSONIP00000053649	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	Tr-type G domain-containing protein.	0.913
Dph1	dnajc24	ENSONIP00000051673	ENSONIP00000058960	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	Uncharacterized protein.	0.599
Dph1	dph2	ENSONIP00000051673	ENSONIP00000006170	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.	0.997
Dph1	dph5	ENSONIP00000051673	ENSONIP00000009798	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	Diphthamide biosynthesis 5.	0.960
Dph1	dph7	ENSONIP00000051673	ENSONIP00000013127	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	Diphthamide biosynthesis 7.	0.694
Dph1	eef2	ENSONIP00000051673	ENSONIP00000041374	2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.	Eukaryotic translation elongation factor 2b.	0.913
EIF5AL1	Dhps	ENSONIP00000037349	ENSONIP00000070653	Eukaryotic translation initiation factor 5A.	Deoxyhypusine synthase.	0.950
EIF5AL1	LOC100702471	ENSONIP00000037349	ENSONIP00000053649	Eukaryotic translation initiation factor 5A.	Tr-type G domain-containing protein.	0.854