STRINGSTRING
ENSONIP00000073729 ENSONIP00000073729 LOC100712315 LOC100712315 trib2 trib2 LOC100710281 LOC100710281 LOC100696779 LOC100696779 mapk15 mapk15 nkpd1 nkpd1 LOC100704913 LOC100704913 LOC100698246 LOC100698246 crkl crkl dusp6 dusp6 RALB RALB LOC100708547 LOC100708547 fosl1 fosl1 LOC100698564 LOC100698564 ppp2r1b ppp2r1b LOC100704141 LOC100704141 LOC100705962 LOC100705962 egr2 egr2 SHC3 SHC3 LOC100693447 LOC100693447 LOC100696389 LOC100696389 LOC100700904 LOC100700904 SRF SRF ap2m1 ap2m1 I3JWC0_ORENI I3JWC0_ORENI I3JWF9_ORENI I3JWF9_ORENI PIK3CA PIK3CA LOC100705099 LOC100705099 LOC100698524 LOC100698524 Egr3 Egr3 LOC100704325 LOC100704325 nab1 nab1 LOC100705713 LOC100705713 chd4 chd4 LOC100697446 LOC100697446 ralgds ralgds irs2 irs2 LOC100703163 LOC100703163 kras kras LOC100534480 LOC100534480 clta clta LOC100707957 LOC100707957 ppp2ca ppp2ca LOC100707472 LOC100707472 LOC100707861 LOC100707861 LOC100700016 LOC100700016 LOC109194293 LOC109194293 MAPKAPK3 MAPKAPK3 LOC100691519 LOC100691519 LOC100706722 LOC100706722 LOC100692989 LOC100692989 LOC100696124 LOC100696124 JUND JUND LOC100707881 LOC100707881 ascl1 ascl1 I3L042_ORENI I3L042_ORENI LOC102082809 LOC102082809 ppp4r4 ppp4r4 LOC100706678 LOC100706678 I3JJI6_ORENI I3JJI6_ORENI LOC102077703 LOC102077703 LOC100695849 LOC100695849 map2k5 map2k5 ENSONIP00000039289 ENSONIP00000039289 I3KZC4_ORENI I3KZC4_ORENI LOC100692096 LOC100692096 hras hras CSDE1 CSDE1 creb1 creb1 ENSONIP00000053841 ENSONIP00000053841 Mapkapk3 Mapkapk3 SGK1 SGK1 ppp4r1 ppp4r1 LOC100696873 LOC100696873 vrk3 vrk3 dusp7 dusp7 LOC100704479 LOC100704479 rapgef1 rapgef1 LOC100692416 LOC100692416 Pik3cb Pik3cb LOC100700052 LOC100700052 grb2 grb2 LOC100703836 LOC100703836 egr1 egr1 Relch Relch map2k1 map2k1 LOC100696314 LOC100696314 ap2s1 ap2s1 LOC100702880 LOC100702880 LOC100697392 LOC100697392 LOC100692909 LOC100692909 ENSONIP00000074581 ENSONIP00000074581 LOC100700010 LOC100700010 LOC100702259 LOC100702259 dnal4 dnal4 LOC100697722 LOC100697722 LOC100708638 LOC100708638 mapkapk2 mapkapk2 mapk1 mapk1 ENSONIP00000078138 ENSONIP00000078138 LOC100697571 LOC100697571
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSONIP00000073729Fibroblast growth factor receptor substrate 2b. (500 aa)
LOC100712315Uncharacterized protein. (933 aa)
trib2Tribbles pseudokinase 2. (345 aa)
LOC100710281Serine/threonine-protein phosphatase. (309 aa)
LOC100696779SHC (Src homology 2 domain containing) transforming protein 2. (728 aa)
mapk15Mitogen-activated protein kinase. (617 aa)
nkpd1NTPase, KAP family P-loop domain containing 1. (736 aa)
LOC100704913Uncharacterized protein. (200 aa)
LOC100698246ANK_REP_REGION domain-containing protein. (1689 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
dusp6Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (383 aa)
RALBRAS like proto-oncogene B. (207 aa)
LOC100708547Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (408 aa)
fosl1FOS-like antigen 1a. (344 aa)
LOC100698564Ribosomal protein S6 kinase. (747 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (676 aa)
LOC100704141Inhibitor of DNA binding 4. (141 aa)
LOC100705962Chromodomain helicase DNA binding protein 4a. (1970 aa)
egr2Early growth response 2b. (446 aa)
SHC3SHC adaptor protein 3. (668 aa)
LOC100693447Mitogen-activated protein kinase. (364 aa)
LOC100696389Uncharacterized protein. (320 aa)
LOC100700904Mitogen-activated protein kinase. (365 aa)
SRFSerum response factor. (597 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
I3JWC0_ORENIFormin binding protein 4. (812 aa)
I3JWF9_ORENIMADS-box domain-containing protein. (506 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
LOC100705099CRK proto-oncogene, adaptor protein. (315 aa)
LOC100698524Uncharacterized protein. (348 aa)
Egr3Early growth response 3. (399 aa)
LOC100704325Insulin receptor substrate 2a. (1052 aa)
nab1NGFI-A binding protein 1a (EGR1 binding protein 1). (502 aa)
LOC100705713Serine/threonine-protein phosphatase. (311 aa)
chd4Uncharacterized protein. (1977 aa)
LOC100697446cAMP responsive element binding protein 1. (318 aa)
ralgdsRal guanine nucleotide dissociation stimulator. (860 aa)
irs2Insulin receptor substrate 2b. (1109 aa)
LOC100703163ETS domain-containing protein Elk-3 isoform X4. (583 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
LOC100534480Uncharacterized protein. (318 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (230 aa)
LOC100707957Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (383 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC100707472AP complex subunit beta. (953 aa)
LOC100707861Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC100700016BHLH domain-containing protein. (468 aa)
LOC109194293Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (217 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (429 aa)
LOC100691519NGFI-A binding protein 2 (EGR1 binding protein 2). (498 aa)
LOC100706722Achaete-scute family bHLH transcription factor 1b. (203 aa)
LOC100692989Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (296 aa)
LOC100696124Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (232 aa)
JUNDBZIP domain-containing protein. (272 aa)
LOC100707881JunB proto-oncogene, AP-1 transcription factor subunit b. (329 aa)
ascl1Achaete-scute family bHLH transcription factor 1a. (188 aa)
I3L042_ORENIJunD proto-oncogene, AP-1 transcription factor subunit. (314 aa)
LOC102082809Mitogen-activated protein kinase 7. (1120 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (950 aa)
LOC100706678Inhibitor of DNA binding 3. (122 aa)
I3JJI6_ORENIDDE_Tnp_1_7 domain-containing protein. (510 aa)
LOC102077703Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (205 aa)
LOC100695849Ribosomal protein S6 kinase. (792 aa)
map2k5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (438 aa)
ENSONIP00000039289annotation not available (471 aa)
I3KZC4_ORENIJunB proto-oncogene, AP-1 transcription factor subunit a. (300 aa)
LOC100692096Ribosomal protein S6 kinase. (763 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (873 aa)
creb1Uncharacterized protein. (340 aa)
ENSONIP00000053841annotation not available (99 aa)
Mapkapk3Mitogen-activated protein kinase-activated protein kinase 3. (417 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (626 aa)
ppp4r1WRNPLPNID domain-containing protein. (982 aa)
LOC100696873Ribosomal protein S6 kinase. (842 aa)
vrk3Inactive serine/threonine-protein kinase VRK3 isoform X1. (589 aa)
dusp7Dual specificity MAP kinase phosphatase. (384 aa)
LOC100704479Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1072 aa)
rapgef1Rap guanine nucleotide exchange factor (GEF) 1b. (1200 aa)
LOC100692416Mitogen-activated protein kinase. (376 aa)
Pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1085 aa)
LOC100700052AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (965 aa)
grb2Growth factor receptor-bound protein 2b. (222 aa)
LOC100703836Zgc:55558. (250 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (514 aa)
RelchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1196 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (396 aa)
LOC100696314AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (994 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
LOC100702880Activating transcription factor 1. (311 aa)
LOC100697392V-ral simian leukemia viral oncogene homolog Aa (ras related). (199 aa)
LOC100692909SH3 domain containing GRB2 like 2a, endophilin A1. (363 aa)
ENSONIP00000074581PiggyBac transposable element-derived protein 4. (431 aa)
LOC100700010Kinase D-interacting substrate 220b. (1753 aa)
LOC100702259Tribbles pseudokinase 1. (362 aa)
dnal4Dynein light chain 4, axonemal. (119 aa)
LOC100697722Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (398 aa)
LOC100708638BZIP domain-containing protein. (207 aa)
mapkapk2MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (434 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
ENSONIP00000078138PiggyBac transposable element-derived protein 4. (371 aa)
LOC100697571Mitogen-activated protein kinase kinase 2b. (397 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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