83 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100695712	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (464 aa)
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	LOC100691708	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (305 aa)
	pak1	Non-specific serine/threonine protein kinase. (669 aa)
	ENSONIP00000001878	annotation not available (597 aa)
	I3IZM5_ORENI	DDE_Tnp_1_7 domain-containing protein. (398 aa)
	LOC100698922	MALT paracaspase 2. (826 aa)
	pag1	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (446 aa)
	LOC100692000	Ig-like domain-containing protein. (206 aa)
	LOC100703880	F-box and WD repeat domain containing 11a. (562 aa)
	card11	Caspase recruitment domain family, member 11. (1162 aa)
	cd247	T-cell surface glycoprotein CD3 zeta chain. (150 aa)
	bcl10	BCL10 immune signaling adaptor. (247 aa)
	LOC100692869	Component of inhibitor of nuclear factor kappa B kinase complex. (757 aa)
	I3KGL6_ORENI	DDE_Tnp_1_7 domain-containing protein. (608 aa)
	LOC100710037	Growth factor receptor-bound protein 2-B isoform X1. (290 aa)
	Plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
	ptpn12	Uncharacterized protein. (797 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	LOC102077990	MALT paracaspase 3. (646 aa)
	I3KGC2_ORENI	Immunoglobulin superfamily, member 3. (1044 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	LOC100710113	Protein tyrosine phosphatase non-receptor type 22. (831 aa)
	LOC100707481	MALT paracaspase 1. (828 aa)
	LOC100710443	GRB2 related adaptor protein 2b. (241 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
	itk	Tyrosine-protein kinase. (617 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (720 aa)
	LOC100698148	Protein kinase domain-containing protein. (777 aa)
	LOC100694531	Si:ch211-188c16.1. (894 aa)
	LOC100711065	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1294 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	I3KZ30_ORENI	DDE_Tnp_1_7 domain-containing protein. (554 aa)
	I3IV31_ORENI	Uncharacterized protein. (212 aa)
	ENSONIP00000028040	annotation not available (116 aa)
	LOC112844729	Uncharacterized protein. (618 aa)
	ENSONIP00000029841	annotation not available (163 aa)
	LOC100712348	Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (254 aa)
	cd3e	T-cell surface glycoprotein CD3 epsilon chain. (172 aa)
	I3KIS7_ORENI	Uncharacterized protein. (145 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (593 aa)
	ENSONIP00000032932	annotation not available (263 aa)
	spns1	Spinster homolog 1 (Drosophila). (510 aa)
	CSK	Tyrosine-protein kinase. (491 aa)
	LOC100712236	Spinster homolog 3 (Drosophila). (509 aa)
	ENSONIP00000034453	Si:ch211-130m23.5. (509 aa)
	CSK-2	Tyrosine-protein kinase. (452 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1133 aa)
	ENSONIP00000036250	annotation not available (123 aa)
	ENSONIP00000036669	annotation not available (165 aa)
	LOC102081483	Ubiquitin-conjugating enzyme E2 variant 1. (153 aa)
	pak2	Non-specific serine/threonine protein kinase. (536 aa)
	ENSONIP00000041848	annotation not available (121 aa)
	map3k20	Uncharacterized protein. (833 aa)
	ENSONIP00000046606	annotation not available (105 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (686 aa)
	ENSONIP00000047667	annotation not available (279 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	ENSONIP00000048192	annotation not available (136 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (757 aa)
	ENSONIP00000053627	annotation not available (118 aa)
	ENSONIP00000055480	annotation not available (155 aa)
	SPNS2	Sphingolipid transporter 2. (513 aa)
	ENSONIP00000055836	annotation not available (1128 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (616 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (570 aa)
	ENSONIP00000057896	annotation not available (185 aa)
	ENSONIP00000058877	annotation not available (454 aa)
	LOC100712512	Sterile alpha motif and leucine zipper containing kinase AZK. (668 aa)
	ikbkg	Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (621 aa)
	LOC100699741	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (138 aa)
	LOC112846904	PiggyBac transposable element-derived protein 4-like. (320 aa)
	ENSONIP00000064494	annotation not available (266 aa)
	LOC100694831	DDE_Tnp_1_7 domain-containing protein. (628 aa)
	ENSONIP00000066230	PiggyBac transposable element-derived protein 4 isoform X3. (523 aa)
	ENSONIP00000068140	annotation not available (128 aa)
	tab2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (738 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (536 aa)
	LOC102078467	DDE_Tnp_1_7 domain-containing protein. (406 aa)
	PAK3	P21 (RAC1) activated kinase 3. (655 aa)
	LOC106098917	Chimeric ERCC6-PGBD3 protein. (737 aa)
	LOC102077259	FYN-binding protein 1 isoform X1. (556 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSK	ENSONIP00000047919	ENSONIP00000033737	ENSONIP00000047919	Tyrosine-protein kinase.	Ubiquitin B.	0.440
CSK	I3KIS7_ORENI	ENSONIP00000033737	ENSONIP00000032182	Tyrosine-protein kinase.	Uncharacterized protein.	0.492
CSK	LOC100695712	ENSONIP00000033737	ENSONIP00000000487	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.500
CSK	LOC100710113	ENSONIP00000033737	ENSONIP00000020960	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.718
CSK	LOC100711065	ENSONIP00000033737	ENSONIP00000024520	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.420
CSK	PTEN	ENSONIP00000033737	ENSONIP00000071682	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.500
CSK	Plcg2	ENSONIP00000033737	ENSONIP00000013486	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.420
CSK	cd247	ENSONIP00000033737	ENSONIP00000011324	Tyrosine-protein kinase.	T-cell surface glycoprotein CD3 zeta chain.	0.601
CSK	cd3e	ENSONIP00000033737	ENSONIP00000032160	Tyrosine-protein kinase.	T-cell surface glycoprotein CD3 epsilon chain.	0.594
CSK	pag1	ENSONIP00000033737	ENSONIP00000003296	Tyrosine-protein kinase.	Phosphoprotein membrane anchor with glycosphingolipid microdomains 1.	0.898
CSK	pdpk1	ENSONIP00000033737	ENSONIP00000032736	Tyrosine-protein kinase.	3-phosphoinositide dependent protein kinase 1b.	0.409
CSK	plcg1	ENSONIP00000033737	ENSONIP00000021988	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.420
CSK	ptpn12	ENSONIP00000033737	ENSONIP00000014783	Tyrosine-protein kinase.	Uncharacterized protein.	0.718
CSK	uba52	ENSONIP00000033737	ENSONIP00000016035	Tyrosine-protein kinase.	Ubiquitin A-52 residue ribosomal protein fusion product 1.	0.434
CSK-2	ENSONIP00000047919	ENSONIP00000035459	ENSONIP00000047919	Tyrosine-protein kinase.	Ubiquitin B.	0.440
CSK-2	I3KIS7_ORENI	ENSONIP00000035459	ENSONIP00000032182	Tyrosine-protein kinase.	Uncharacterized protein.	0.492
CSK-2	LOC100695712	ENSONIP00000035459	ENSONIP00000000487	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.500
CSK-2	LOC100710113	ENSONIP00000035459	ENSONIP00000020960	Tyrosine-protein kinase.	Protein tyrosine phosphatase non-receptor type 22.	0.718
CSK-2	LOC100711065	ENSONIP00000035459	ENSONIP00000024520	Tyrosine-protein kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.420
CSK-2	PTEN	ENSONIP00000035459	ENSONIP00000071682	Tyrosine-protein kinase.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.500