STRINGSTRING
LOC100711032 LOC100711032 pak1 pak1 actr2 actr2 I3IX04_ORENI I3IX04_ORENI PAK2 PAK2 LOC100712288 LOC100712288 LOC100697238 LOC100697238 rock2 rock2 cdc42 cdc42 NCSTN NCSTN ENSONIP00000035480 ENSONIP00000035480 ACTR3B ACTR3B cltb cltb I3JA84_ORENI I3JA84_ORENI LOC100690173 LOC100690173 LOC100708728 LOC100708728 arhgef7 arhgef7 LOC102077129 LOC102077129 I3KJT5_ORENI I3KJT5_ORENI LOC100710620 LOC100710620 LOC100708129 LOC100708129 EPHA6 EPHA6 LOC100708995 LOC100708995 LOC100698758 LOC100698758 LOC100695482 LOC100695482 LOC100696931 LOC100696931 mmp2 mmp2 LOC100712047 LOC100712047 actb actb efnb2 efnb2 itsn1 itsn1 LOC100699012 LOC100699012 LOC100534577 LOC100534577 epha3 epha3 epha10 epha10 mmp9 mmp9 ENSONIP00000049596 ENSONIP00000049596 LOC100705710 LOC100705710 ENSONIP00000048570 ENSONIP00000048570 hras hras hspb6 hspb6 ENSONIP00000047028 ENSONIP00000047028 rasa1 rasa1 grin2b grin2b arpc1a arpc1a epha7 epha7 arpc2 arpc2 LOC100699229 LOC100699229 LOC100709700 LOC100709700 pak2 pak2 VAV1 VAV1 LOC100699342 LOC100699342 LOC100691387 LOC100691387 was was YES1 YES1 LOC100692677 LOC100692677 LOC100711948 LOC100711948 dnm1 dnm1 LOC100711706 LOC100711706 arpc5 arpc5 LOC100700052 LOC100700052 LOC100696557 LOC100696557 LOC100703532 LOC100703532 cltc cltc Urb2 Urb2 LOC100712562 LOC100712562 aph1a aph1a ENSONIP00000069341 ENSONIP00000069341 I3KNJ4_ORENI I3KNJ4_ORENI ap2s1 ap2s1 I3IW35_ORENI I3IW35_ORENI I3JIW9_ORENI I3JIW9_ORENI I3JQQ1_ORENI I3JQQ1_ORENI LOC100696600 LOC100696600 epha5 epha5 fyn fyn EFNA5 EFNA5 LOC100707941 LOC100707941 I3IZQ5_ORENI I3IZQ5_ORENI PAK3 PAK3 LOC100711908 LOC100711908 ENSONIP00000077525 ENSONIP00000077525 fndc3a fndc3a LOC100695691 LOC100695691 vav2 vav2 ephb4 ephb4 LOC100705514 LOC100705514 Arpc3 Arpc3 LOC100691909 LOC100691909 LOC100707472 LOC100707472 clta clta epha4 epha4 LOC100704245 LOC100704245 LOC100706927 LOC100706927 ENSONIP00000016270 ENSONIP00000016270 LOC100702199 LOC100702199 LOC100706624 LOC100706624 ephb3 ephb3 FMN1 FMN1 I3K140_ORENI I3K140_ORENI LOC100706883 LOC100706883 ap2m1 ap2m1 LOC100711975 LOC100711975 LOC100696145 LOC100696145 LOC100691336 LOC100691336 Rock1 Rock1 I3JMN2_ORENI I3JMN2_ORENI I3JM11_ORENI I3JM11_ORENI LOC100705337 LOC100705337 LOC100705703 LOC100705703 LOC100705444 LOC100705444 SRC SRC LOC100703653 LOC100703653 ngef ngef I3JGF8_ORENI I3JGF8_ORENI I3JE78_ORENI I3JE78_ORENI Tiam1 Tiam1 cfl1 cfl1 VAV3 VAV3 LOC100700380 LOC100700380 LOC100711937 LOC100711937 epha8 epha8 LOC100705458 LOC100705458
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100711032Ephrin RBD domain-containing protein; Belongs to the ephrin family. (402 aa)
pak1Non-specific serine/threonine protein kinase. (669 aa)
actr2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
I3IX04_ORENIEphrin-A2a; Belongs to the ephrin family. (224 aa)
PAK2Non-specific serine/threonine protein kinase. (510 aa)
LOC100712288Eph receptor B2b. (1021 aa)
LOC100697238Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (486 aa)
rock2Rho-associated, coiled-coil containing protein kinase 2a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1394 aa)
cdc42Cell division cycle 42. (209 aa)
NCSTNNicastrin. (697 aa)
ENSONIP00000035480Actin related protein 2/3 complex, subunit 4. (203 aa)
ACTR3BActin related protein 3C; Belongs to the actin family. (517 aa)
cltbClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (224 aa)
I3JA84_ORENIEph receptor B4b. (947 aa)
LOC100690173Glutamate receptor, ionotropic, N-methyl D-aspartate 1b. (1060 aa)
LOC100708728Ephrin-A1a; Belongs to the ephrin family. (227 aa)
arhgef7Rho guanine nucleotide exchange factor (GEF) 7a. (862 aa)
LOC102077129Si:dkey-246i14.3; Belongs to the ephrin family. (200 aa)
I3KJT5_ORENIEph receptor B2a. (1019 aa)
LOC100710620Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (460 aa)
LOC100708129Tyrosine-protein kinase. (556 aa)
EPHA6EPH receptor A6. (1005 aa)
LOC100708995Ephrin-A3a; Belongs to the ephrin family. (224 aa)
LOC100698758T cell lymphoma invasion and metastasis 1a. (1674 aa)
LOC100695482Zgc:101810; Belongs to the actin family. (394 aa)
LOC100696931Rho guanine nucleotide exchange factor (GEF) 7b. (849 aa)
mmp2Matrix metallopeptidase 2. (657 aa)
LOC100712047Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (958 aa)
actbUncharacterized protein. (376 aa)
efnb2Ephrin-B2a; Belongs to the ephrin family. (335 aa)
itsn1Intersectin 1 (SH3 domain protein). (1795 aa)
LOC100699012Fibronectin type III domain containing 3Ba. (1174 aa)
LOC100534577Glutamate receptor, ionotropic, N-methyl D-aspartate 1a. (973 aa)
epha3Eph receptor A3. (994 aa)
epha10Uncharacterized protein. (1069 aa)
mmp9Matrix metallopeptidase 9. (691 aa)
ENSONIP00000049596NACHT, LRR and PYD domains-containing protein 1b allele 2 isoform X1. (91 aa)
LOC100705710Fibronectin type-III domain-containing protein. (836 aa)
ENSONIP00000048570annotation not available (155 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
hspb6Heat shock protein, alpha-crystallin-related, b6; Belongs to the small heat shock protein (HSP20) family. (243 aa)
ENSONIP00000047028Actin related protein 2/3 complex, subunit 3. (186 aa)
rasa1RAS p21 protein activator (GTPase activating protein) 1a. (1063 aa)
grin2bUncharacterized protein. (1717 aa)
arpc1aActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
epha7Eph receptor A7. (1015 aa)
arpc2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (463 aa)
LOC100699229Uncharacterized protein; Belongs to the actin family. (454 aa)
LOC100709700Eph receptor A6. (1048 aa)
pak2Non-specific serine/threonine protein kinase. (536 aa)
VAV1Vav guanine nucleotide exchange factor 1. (869 aa)
LOC100699342Cofilin 2 (muscle); Belongs to the actin-binding proteins ADF family. (166 aa)
LOC100691387Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1642 aa)
wasUncharacterized protein. (550 aa)
YES1Tyrosine-protein kinase. (555 aa)
LOC100692677Tyrosine-protein kinase. (593 aa)
LOC100711948Actin related protein 3; Belongs to the actin family. (429 aa)
dnm1Dynamin 1a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (861 aa)
LOC100711706Uncharacterized protein. (1092 aa)
arpc5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (160 aa)
LOC100700052AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (965 aa)
LOC100696557Uncharacterized protein. (191 aa)
LOC100703532Ephrin-B1; Belongs to the ephrin family. (352 aa)
cltcClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1686 aa)
Urb2URB2 ribosome biogenesis homolog. (112 aa)
LOC100712562Uncharacterized protein. (191 aa)
aph1aAPH1B gamma secretase subunit. (258 aa)
ENSONIP00000069341Uncharacterized protein LOC102081220 isoform X1. (350 aa)
I3KNJ4_ORENIGlutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b. (1728 aa)
ap2s1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (155 aa)
I3IW35_ORENIFH2 domain-containing protein. (1091 aa)
I3JIW9_ORENIUncharacterized protein. (195 aa)
I3JQQ1_ORENIUncharacterized protein. (994 aa)
LOC100696600Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (217 aa)
epha5Uncharacterized protein. (1013 aa)
fynTyrosine-protein kinase. (538 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (230 aa)
LOC100707941Ephrin-B3a; Belongs to the ephrin family. (340 aa)
I3IZQ5_ORENIActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (163 aa)
PAK3P21 (RAC1) activated kinase 3. (655 aa)
LOC100711908Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1705 aa)
ENSONIP00000077525annotation not available (311 aa)
fndc3aFibronectin type III domain containing 3A. (1239 aa)
LOC100695691Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (383 aa)
vav2Vav 2 guanine nucleotide exchange factor. (893 aa)
ephb4Eph receptor B4a. (990 aa)
LOC100705514Ephrin-A1b; Belongs to the ephrin family. (274 aa)
Arpc3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
LOC100691909Vav 3 guanine nucleotide exchange factor b. (843 aa)
LOC100707472AP complex subunit beta. (953 aa)
cltaClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (230 aa)
epha4Eph receptor A4, like. (989 aa)
LOC100704245Uncharacterized protein. (407 aa)
LOC100706927Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (216 aa)
ENSONIP00000016270Si:ch211-1o7.3. (518 aa)
LOC100702199Receptor protein-tyrosine kinase. (1009 aa)
LOC100706624Ephrin-A5a; Belongs to the ephrin family. (229 aa)
ephb3Uncharacterized protein. (1013 aa)
FMN1FH2 domain-containing protein. (1246 aa)
I3K140_ORENIWASP like actin nucleation promoting factor b. (523 aa)
LOC100706883Eph receptor B3a. (926 aa)
ap2m1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (434 aa)
LOC100711975Eph receptor A4b. (984 aa)
LOC100696145EPH receptor B1. (1007 aa)
LOC100691336ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (156 aa)
Rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1353 aa)
I3JMN2_ORENIFormin 2b. (1312 aa)
I3JM11_ORENIActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (381 aa)
LOC100705337Ephrin RBD domain-containing protein; Belongs to the ephrin family. (269 aa)
LOC100705703Uncharacterized protein. (190 aa)
LOC100705444Uncharacterized protein. (189 aa)
SRCTyrosine-protein kinase. (550 aa)
LOC100703653Receptor protein-tyrosine kinase. (986 aa)
ngefNeuronal guanine nucleotide exchange factor. (767 aa)
I3JGF8_ORENIEphrin-A3b; Belongs to the ephrin family. (319 aa)
I3JE78_ORENIFormin 1. (1023 aa)
Tiam1T cell lymphoma invasion and metastasis 1b. (1553 aa)
cfl1Cofilin 1; Belongs to the actin-binding proteins ADF family. (150 aa)
VAV3Vav guanine nucleotide exchange factor 3. (864 aa)
LOC100700380Eph receptor A2 a. (974 aa)
LOC100711937WASP like actin nucleation promoting factor a. (538 aa)
epha8Uncharacterized protein. (1029 aa)
LOC100705458Syndecan binding protein (syntenin) 2. (304 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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