84 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSONIP00000061996	annotation not available (157 aa)
	smc5	SMC_N domain-containing protein. (1089 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	smc1a	Structural maintenance of chromosomes protein. (1231 aa)
	ENSONIP00000064374	Small ubiquitin-related modifier 2. (90 aa)
	ube2i	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	nup133	Nucleoporin 133. (1135 aa)
	ENSONIP00000067816	annotation not available (1740 aa)
	LOC100709166	Small ubiquitin-related modifier. (94 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	LOC100699832	Necdin-like 2. (323 aa)
	sumo1	Small ubiquitin-related modifier. (101 aa)
	smc3	Structural maintenance of chromosomes protein. (1223 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1023 aa)
	nup58	Nucleoporin 58. (599 aa)
	cbx2	Chromobox homolog 2 (Drosophila Pc class). (527 aa)
	cbx8	Chromobox homolog 8b. (362 aa)
	nup107	Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (920 aa)
	LOC100696737	POM121 transmembrane nucleoporin. (1177 aa)
	LOC100691685	E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (442 aa)
	I3KKM5_ORENI	Chromobox homolog 8a (Pc class homolog, Drosophila). (350 aa)
	aaas	Achalasia, adrenocortical insufficiency, alacrimia. (520 aa)
	LOC100698455	RAD21 cohesin complex component like 1. (547 aa)
	LOC100694797	Translocated promoter region a, nuclear basket protein. (2505 aa)
	brca1	Uncharacterized protein. (1392 aa)
	LOC102077312	Calcyon neuron-specific vesicular protein. (201 aa)
	nsmce1	NSE1 homolog, SMC5-SMC6 complex component. (285 aa)
	nup35	Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family. (294 aa)
	scmh1	SAM domain-containing protein. (774 aa)
	Xrcc4	Uncharacterized protein. (165 aa)
	I3KER7_ORENI	Thymine DNA glycosylase, tandem duplicate 2. (410 aa)
	tdg	Thymine DNA glycosylase, tandem duplicate 1. (449 aa)
	blm	BLM RecQ like helicase. (1407 aa)
	rad52	DNA repair and recombination protein RAD52. (417 aa)
	nup155	Nucleoporin 155. (1365 aa)
	LOC100705420	RAD21 cohesin complex component b. (649 aa)
	Smc6	Si:dkey-119f1.1. (1100 aa)
	I3K4Y7_ORENI	Uncharacterized protein. (768 aa)
	LOC100705560	X-ray repair complementing defective repair in Chinese hamster cells 4. (336 aa)
	tpr	Translocated promoter region b, nuclear basket protein. (2364 aa)
	I3JPJ2_ORENI	Uncharacterized protein. (587 aa)
	nup50	Nucleoporin 50. (468 aa)
	nup188	Nucleoporin 188. (1746 aa)
	nsmce2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (230 aa)
	LOC100710134	RAD21 cohesin complex component a. (637 aa)
	LOC100707304	Uncharacterized protein. (984 aa)
	nup43	Nucleoporin 43. (372 aa)
	LOC100699925	Scm polycomb group protein like 2. (685 aa)
	SCML2	Scm polycomb group protein like 2. (685 aa)
	xpc	Xeroderma pigmentosum, complementation group C. (930 aa)
	LOC100695822	Centrin 4. (171 aa)
	LOC100705580	Structural maintenance of chromosomes 6. (1100 aa)
	kctd2	Potassium channel tetramerization domain containing 2. (273 aa)
	phc3	Uncharacterized protein. (938 aa)
	CBX2	Chromobox 2. (533 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	ENSONIP00000024927	RecQ helicase-like 4. (958 aa)
	nup88	Nucleoporin 88. (719 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
	LOC100703806	Stromal antigen 2b. (1280 aa)
	I3J9E8_ORENI	Stromal antigen 2a. (1218 aa)
	LOC109202395	Small ubiquitin-related modifier 2. (145 aa)
	Bmi1	Bmi1 polycomb ring finger oncogene 1a. (335 aa)
	nup85	Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (652 aa)
	LOC100690637	Small ubiquitin-related modifier. (94 aa)
	nsmce4a	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (351 aa)
	seh1l	SEH1-like (S. cerevisiae); Belongs to the WD repeat SEC13 family. (415 aa)
	ENSONIP00000047290	annotation not available (102 aa)
	nup42	Nucleoporin 42. (439 aa)
	LOC100692890	RAN binding protein 2. (3035 aa)
	nup37	Nucleoporin 37. (325 aa)
	pcgf2	RING-type domain-containing protein. (331 aa)
	cetn3	Centrin 3. (181 aa)
	RING1	RING-type domain-containing protein. (394 aa)
	I3KKM2_ORENI	Chromobox homolog 4 (Pc class homolog, Drosophila). (548 aa)
	ENSONIP00000055510	annotation not available (59 aa)
	nup210	Nucleoporin 210. (1886 aa)
	nup93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (820 aa)
	stag1	Stromal antigen 1a. (1264 aa)
	rnf2	Ring finger protein 2. (397 aa)
	rae1	Ribonucleic acid export 1. (398 aa)
	cbx4	Chromobox 4. (573 aa)
	nup160	Nucleoporin 160. (1399 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bmi1	CBX2	ENSONIP00000034886	ENSONIP00000024026	Bmi1 polycomb ring finger oncogene 1a.	Chromobox 2.	0.867
Bmi1	ENSONIP00000061996	ENSONIP00000034886	ENSONIP00000061996	Bmi1 polycomb ring finger oncogene 1a.	annotation not available	0.543
Bmi1	I3K4Y7_ORENI	ENSONIP00000034886	ENSONIP00000016183	Bmi1 polycomb ring finger oncogene 1a.	Uncharacterized protein.	0.599
Bmi1	I3KKM2_ORENI	ENSONIP00000034886	ENSONIP00000053659	Bmi1 polycomb ring finger oncogene 1a.	Chromobox homolog 4 (Pc class homolog, Drosophila).	0.848
Bmi1	I3KKM5_ORENI	ENSONIP00000034886	ENSONIP00000021670	Bmi1 polycomb ring finger oncogene 1a.	Chromobox homolog 8a (Pc class homolog, Drosophila).	0.859
Bmi1	LOC100699925	ENSONIP00000034886	ENSONIP00000004307	Bmi1 polycomb ring finger oncogene 1a.	Scm polycomb group protein like 2.	0.815
Bmi1	LOC100707304	ENSONIP00000034886	ENSONIP00000008853	Bmi1 polycomb ring finger oncogene 1a.	Uncharacterized protein.	0.599
Bmi1	RING1	ENSONIP00000034886	ENSONIP00000053310	Bmi1 polycomb ring finger oncogene 1a.	RING-type domain-containing protein.	0.948
Bmi1	SCML2	ENSONIP00000034886	ENSONIP00000003960	Bmi1 polycomb ring finger oncogene 1a.	Scm polycomb group protein like 2.	0.815
Bmi1	cbx2	ENSONIP00000034886	ENSONIP00000075634	Bmi1 polycomb ring finger oncogene 1a.	Chromobox homolog 2 (Drosophila Pc class).	0.858
Bmi1	cbx4	ENSONIP00000034886	ENSONIP00000060916	Bmi1 polycomb ring finger oncogene 1a.	Chromobox 4.	0.848
Bmi1	cbx8	ENSONIP00000034886	ENSONIP00000075927	Bmi1 polycomb ring finger oncogene 1a.	Chromobox homolog 8b.	0.859
Bmi1	kctd2	ENSONIP00000034886	ENSONIP00000022883	Bmi1 polycomb ring finger oncogene 1a.	Potassium channel tetramerization domain containing 2.	0.502
Bmi1	phc3	ENSONIP00000034886	ENSONIP00000023436	Bmi1 polycomb ring finger oncogene 1a.	Uncharacterized protein.	0.860
Bmi1	rnf2	ENSONIP00000034886	ENSONIP00000057751	Bmi1 polycomb ring finger oncogene 1a.	Ring finger protein 2.	0.948
Bmi1	scmh1	ENSONIP00000034886	ENSONIP00000020379	Bmi1 polycomb ring finger oncogene 1a.	SAM domain-containing protein.	0.815
Bmi1	sumo1	ENSONIP00000034886	ENSONIP00000072692	Bmi1 polycomb ring finger oncogene 1a.	Small ubiquitin-related modifier.	0.437
Bmi1	ube2i	ENSONIP00000034886	ENSONIP00000066419	Bmi1 polycomb ring finger oncogene 1a.	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family.	0.543
CBX2	Bmi1	ENSONIP00000024026	ENSONIP00000034886	Chromobox 2.	Bmi1 polycomb ring finger oncogene 1a.	0.867
CBX2	I3K4Y7_ORENI	ENSONIP00000024026	ENSONIP00000016183	Chromobox 2.	Uncharacterized protein.	0.573