STRINGSTRING
ENSONIP00000000047 ENSONIP00000000047 cdc6 cdc6 orc5 orc5 LOC100701228 LOC100701228 ccna2 ccna2 mcm8 mcm8 LOC100692568 LOC100692568 LOC100710281 LOC100710281 LOC109194384 LOC109194384 LOC100708142 LOC100708142 pole4 pole4 LOC100707077 LOC100707077 lin37 lin37 psmb3 psmb3 psmd14 psmd14 Ccne1 Ccne1 orc3 orc3 Psmb4 Psmb4 Psmd8 Psmd8 LOC100691373 LOC100691373 LOC100707971 LOC100707971 pola2 pola2 rbl1 rbl1 LOC100705578 LOC100705578 PSMA4 PSMA4 ppp2r1b ppp2r1b dbf4 dbf4 psmd12 psmd12 psme2 psme2 SRC SRC E2F3 E2F3 psma2 psma2 psmd5 psmd5 I3JLK9_ORENI I3JLK9_ORENI orc1 orc1 psme1 psme1 mcm5 mcm5 ENSONIP00000010727 ENSONIP00000010727 cdkn1b cdkn1b LOC100711644 LOC100711644 e2f1 e2f1 cables1 cables1 mcm4 mcm4 prim2 prim2 LOC100712090 LOC100712090 LOC100692625 LOC100692625 I3JWC0_ORENI I3JWC0_ORENI Cdc7 Cdc7 LOC100710763 LOC100710763 psmd2 psmd2 skp2 skp2 LOC100705995 LOC100705995 mcm10 mcm10 CDC25B CDC25B ccna1 ccna1 uba52 uba52 LOC100705713 LOC100705713 cdt1 cdt1 psmd9 psmd9 pole pole psmb2 psmb2 abl1 abl1 tfdp1 tfdp1 pola1 pola1 kxd1 kxd1 psmd7 psmd7 lin54 lin54 wee1 wee1 I3KF05_ORENI I3KF05_ORENI mcm6 mcm6 rps27a rps27a rpa2 rpa2 LOC100701743 LOC100701743 LOC100698501 LOC100698501 LOC100695798 LOC100695798 psmc3 psmc3 skp1 skp1 ppp2ca ppp2ca LOC100706559 LOC100706559 LOC100692495 LOC100692495 psme3 psme3 LOC100690263 LOC100690263 LOC102082412 LOC102082412 psma5 psma5 Ppp2r3c Ppp2r3c I3KUR8_ORENI I3KUR8_ORENI meiob meiob LOC100696839 LOC100696839 LOC100697106 LOC100697106 LOC100697564 LOC100697564 psmb8 psmb8 mnat1 mnat1 mybl2 mybl2 psmc4 psmc4 RPA1 RPA1 mcm9 mcm9 LOC100702193 LOC100702193 e2f2 e2f2 LOC100691978 LOC100691978 psmd1 psmd1 ppp4r4 ppp4r4 LOC102075526 LOC102075526 LOC100710977 LOC100710977 mcm2 mcm2 MYBL2 MYBL2 LOC100710044 LOC100710044 LOC100698323 LOC100698323 LOC100707378 LOC100707378 Psmd10 Psmd10 e2f4 e2f4 cul1 cul1 ccnh ccnh ppp2r3a ppp2r3a ENSONIP00000041766 ENSONIP00000041766 prim1 prim1 psmb1 psmb1 cdkn2d cdkn2d cdc45 cdc45 LOC100693436 LOC100693436 psmd3 psmd3 I3JMM6_ORENI I3JMM6_ORENI ENSONIP00000047919 ENSONIP00000047919 psmc6 psmc6 LOC100710529 LOC100710529 psma1 psma1 lin52 lin52 lin9 lin9 cks1b cks1b LOC100699012 LOC100699012 LOC100708080 LOC100708080 MCM7 MCM7 ppp4r1 ppp4r1 LOC102080582 LOC102080582 cdk6 cdk6 ccnd1 ccnd1 Orc4 Orc4 psmc5 psmc5 mcm3 mcm3 PPP2R3B PPP2R3B LOC100703282 LOC100703282 LOC100692677 LOC100692677 cdk7 cdk7 psma3 psma3 LOC100692090 LOC100692090 ENSONIP00000064494 ENSONIP00000064494 ENSONIP00000064740 ENSONIP00000064740 LOC100694980 LOC100694980 pole3 pole3 Relch Relch rpa1 rpa1 akt1 akt1 psma6 psma6 LOC100707642 LOC100707642 psmc1 psmc1 cdk4 cdk4 rb1 rb1 LOC100692564 LOC100692564 psmc2 psmc2 rpa3 rpa3 fndc3a fndc3a psmd6 psmd6 cdk2 cdk2 LOC100691860 LOC100691860 LOC100690023 LOC100690023 psmd13 psmd13 ENSONIP00000080810 ENSONIP00000080810 LOC100703712 LOC100703712 dyrk1a dyrk1a psmb7 psmb7 psmf1 psmf1 pole2 pole2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSONIP00000000047RAC-gamma serine/threonine-protein kinase. (487 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (604 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
LOC100701228Cdk5 and Abl enzyme substrate 2b; Belongs to the cyclin family. (538 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (876 aa)
LOC100692568Cyclin E2; Belongs to the cyclin family. (397 aa)
LOC100710281Serine/threonine-protein phosphatase. (309 aa)
LOC109194384Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (208 aa)
LOC100708142SCY domain-containing protein. (126 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)
LOC100707077Geminin DNA replication inhibitor. (211 aa)
lin37Lin-37 DREAM MuvB core complex component. (242 aa)
psmb3Proteasome subunit beta. (205 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (333 aa)
Ccne1Cyclin E1; Belongs to the cyclin family. (296 aa)
orc3Origin recognition complex, subunit 3. (720 aa)
Psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
Psmd8Proteasome 26S subunit, non-ATPase 8. (258 aa)
LOC100691373Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (293 aa)
LOC100707971Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
rbl1Retinoblastoma-like 1 (p107). (1064 aa)
LOC100705578E2F_TDP domain-containing protein. (79 aa)
PSMA4Proteasome subunit alpha type. (248 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (676 aa)
dbf4DBF4 zinc finger. (607 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
psme2Proteasome activator subunit 2. (245 aa)
SRCTyrosine-protein kinase. (550 aa)
E2F3E2F transcription factor 3. (444 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (524 aa)
I3JLK9_ORENIE2F_TDP domain-containing protein. (249 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (901 aa)
psme1Proteasome activator subunit 1. (249 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
ENSONIP00000010727Geminin. (215 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
LOC100711644Cyclin-dependent kinase inhibitor 1Cb. (209 aa)
e2f1E2F transcription factor 1. (454 aa)
cables1Cdk5 and Abl enzyme substrate 1. (542 aa)
mcm4DNA helicase; Belongs to the MCM family. (860 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (513 aa)
LOC100712090Cyclin Dx; Belongs to the cyclin family. (296 aa)
LOC100692625Wee1-like protein kinase. (544 aa)
I3JWC0_ORENIFormin binding protein 4. (812 aa)
Cdc7Cell division cycle 7 homolog (S. cerevisiae). (581 aa)
LOC100710763Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (419 aa)
LOC100705995Proteasome subunit beta. (289 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (894 aa)
CDC25BCell division cycle 25B. (571 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (396 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC100705713Serine/threonine-protein phosphatase. (311 aa)
cdt1Chromatin licensing and DNA replication factor 1. (556 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
psmb2Proteasome subunit beta. (204 aa)
abl1Tyrosine-protein kinase. (1104 aa)
tfdp1Transcription factor. (413 aa)
pola1DNA polymerase. (1445 aa)
kxd1KxDL motif containing 1. (184 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (337 aa)
lin54Lin-54 DREAM MuvB core complex component. (805 aa)
wee1Wee1-like protein kinase. (619 aa)
I3KF05_ORENIUncharacterized protein. (510 aa)
mcm6DNA helicase; Belongs to the MCM family. (828 aa)
rps27aRibosomal protein S27a. (156 aa)
rpa2Replication protein A2. (278 aa)
LOC100701743Proteasome subunit alpha type. (246 aa)
LOC100698501Uncharacterized protein. (181 aa)
LOC100695798Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (513 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (428 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC100706559Proteasome 26S subunit, non-ATPase 11b. (424 aa)
LOC100692495Retinoblastoma-like 2 (p130). (1078 aa)
psme3Proteasome activator subunit 3. (256 aa)
LOC100690263Cyclin D3; Belongs to the cyclin family. (317 aa)
LOC102082412Cyclin-dependent kinase inhibitor 1A. (199 aa)
psma5Proteasome subunit alpha type. (241 aa)
Ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (464 aa)
I3KUR8_ORENIProteasome 26S subunit, non-ATPase 4a. (393 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
LOC100696839Proteasome subunit beta. (217 aa)
LOC100697106Proteasome subunit beta 12. (217 aa)
LOC100697564Proteasome subunit beta. (275 aa)
psmb8Proteasome subunit beta. (275 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
mybl2V-myb avian myeloblastosis viral oncogene homolog-like 2b. (626 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1201 aa)
LOC100702193Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
e2f2Si:ch211-160f23.5. (448 aa)
LOC100691978Proteasome subunit alpha type. (256 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (950 aa)
LOC102075526Cyclin E2; Belongs to the cyclin family. (431 aa)
LOC100710977Proteasome subunit beta. (281 aa)
mcm2DNA helicase; Belongs to the MCM family. (899 aa)
MYBL2Uncharacterized protein LOC100690281 isoform X1. (884 aa)
LOC100710044Tyrosine-protein kinase. (1160 aa)
LOC100698323Cyclin D2, a; Belongs to the cyclin family. (297 aa)
LOC100707378Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (127 aa)
Psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
e2f4E2F transcription factor 4. (407 aa)
cul1Cullin 1b; Belongs to the cullin family. (1038 aa)
ccnhCyclin H; Belongs to the cyclin family. (325 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (1403 aa)
ENSONIP00000041766Cyclin-dependent kinase inhibitor 1B. (179 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (454 aa)
psmb1Proteasome subunit beta. (263 aa)
cdkn2dCyclin-dependent kinase 4 inhibitor D. (164 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (574 aa)
LOC100693436Protein-tyrosine kinase 6 isoform X1. (519 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (575 aa)
I3JMM6_ORENIDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B. (647 aa)
ENSONIP00000047919Ubiquitin B. (354 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (435 aa)
LOC100710529Protein lin-54 homolog isoform X1. (456 aa)
psma1Proteasome subunit alpha type. (263 aa)
lin52Protein lin-52 homolog. (155 aa)
lin9Lin-9 DREAM MuvB core complex component. (549 aa)
cks1bCyclin-dependent kinase regulatory subunit CKS1. (109 aa)
LOC100699012Fibronectin type III domain containing 3Ba. (1174 aa)
LOC100708080Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (511 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (743 aa)
ppp4r1WRNPLPNID domain-containing protein. (982 aa)
LOC102080582Proteasome 26S subunit, non-ATPase 4b. (401 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
Orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (454 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (421 aa)
mcm3DNA helicase; Belongs to the MCM family. (817 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (581 aa)
LOC100703282Cyclin-dependent kinase inhibitor 1B. (168 aa)
LOC100692677Tyrosine-protein kinase. (593 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa)
psma3Proteasome subunit alpha type. (285 aa)
LOC100692090Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (77 aa)
ENSONIP00000064494annotation not available (266 aa)
ENSONIP00000064740Cyclin-dependent kinase 4 inhibitor C isoform X2. (172 aa)
LOC100694980Proteasome subunit beta. (327 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
RelchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1196 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
psma6Proteasome 20S subunit alpha 6. (254 aa)
LOC100707642Cyclin D2, b; Belongs to the cyclin family. (294 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (474 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (318 aa)
rb1Retinoblastoma 1. (919 aa)
LOC100692564Tyrosine-protein kinase. (1136 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (487 aa)
rpa3Replication protein A3. (122 aa)
fndc3aFibronectin type III domain containing 3A. (1239 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (407 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (313 aa)
LOC100691860Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
LOC100690023Transcription factor E2F2 isoform X1. (397 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (379 aa)
ENSONIP00000080810annotation not available (186 aa)
LOC100703712PCI domain-containing protein. (445 aa)
dyrk1aDual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, b. (755 aa)
psmb7Proteasome subunit beta. (326 aa)
psmf1Proteasome inhibitor subunit 1. (326 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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