STRINGSTRING
SHC4 SHC4 LOC100704479 LOC100704479 polr2h polr2h LOC100694765 LOC100694765 LOC100695324 LOC100695324 LOC100699012 LOC100699012 CSDE1 CSDE1 I3KNU7_ORENI I3KNU7_ORENI fgf17 fgf17 ENSONIP00000047919 ENSONIP00000047919 hras hras ENSONIP00000046810 ENSONIP00000046810 polr2g polr2g LOC100699655 LOC100699655 fgf6 fgf6 fgf5 fgf5 fgf10 fgf10 ENSONIP00000039289 ENSONIP00000039289 fgfbp2 fgfbp2 POLR2E POLR2E I3JJI6_ORENI I3JJI6_ORENI tia1 tia1 ENSONIP00000031680 ENSONIP00000031680 polr2c polr2c LOC100703764 LOC100703764 LOC100692879 LOC100692879 fgf4 fgf4 LOC100707861 LOC100707861 LOC100693787 LOC100693787 fgf16 fgf16 fgf20b fgf20b LOC100707945 LOC100707945 plcg1 plcg1 ppp2ca ppp2ca fgf20a fgf20a rps27a rps27a Fgfbp3 Fgfbp3 kras kras fgf7 fgf7 LOC100691488 LOC100691488 LOC100705713 LOC100705713 uba52 uba52 hnrnpa1 hnrnpa1 LOC100699525 LOC100699525 PIK3CA PIK3CA tial1 tial1 mknk2 mknk2 I3JUL5_ORENI I3JUL5_ORENI LOC100692645 LOC100692645 LOC100710677 LOC100710677 SRC SRC LOC100707394 LOC100707394 shc1 shc1 ppp2r1b ppp2r1b polr2i polr2i I3J6X6_ORENI I3J6X6_ORENI gtf2f2 gtf2f2 fgf22 fgf22 fgf23 fgf23 gtf2f1 gtf2f1 LOC100710281 LOC100710281 I3J012_ORENI I3J012_ORENI fgf2 fgf2 I3IWZ7_ORENI I3IWZ7_ORENI polr2j polr2j polr2b polr2b polr2k polr2k polr2l polr2l ENSONIP00000078138 ENSONIP00000078138 fndc3a fndc3a mapk1 mapk1 LOC100697722 LOC100697722 ENSONIP00000075314 ENSONIP00000075314 ENSONIP00000074581 ENSONIP00000074581 ENSONIP00000073729 ENSONIP00000073729 esrp1 esrp1 fgf1 fgf1 PTBP3 PTBP3 LOC100708453 LOC100708453 LOC100702413 LOC100702413 polr2a polr2a LOC100704516 LOC100704516 LOC100698788 LOC100698788 LOC100703836 LOC100703836 grb2 grb2 polr2f polr2f PTBP2 PTBP2 Fgfr2 Fgfr2 LOC100692677 LOC100692677 LOC100711270 LOC100711270 I3JG35_ORENI I3JG35_ORENI LOC100699171 LOC100699171 NCBP1 NCBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SHC4SHC adaptor protein 4. (349 aa)
LOC100704479Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1072 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
LOC100694765Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
LOC100695324Uncharacterized protein. (528 aa)
LOC100699012Fibronectin type III domain containing 3Ba. (1174 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (873 aa)
I3KNU7_ORENIFibroblast growth factor; Belongs to the heparin-binding growth factors family. (262 aa)
fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
ENSONIP00000047919Ubiquitin B. (354 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
ENSONIP00000046810Nuclear cap-binding protein subunit 2-like. (91 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (181 aa)
LOC100699655General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (322 aa)
fgf6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (228 aa)
fgf10Fibroblast growth factor 10. (251 aa)
ENSONIP00000039289annotation not available (471 aa)
fgfbp2Fibroblast growth factor-binding protein 2. (261 aa)
POLR2ERNA polymerase II subunit E. (249 aa)
I3JJI6_ORENIDDE_Tnp_1_7 domain-containing protein. (510 aa)
tia1TIA1 cytotoxic granule-associated RNA binding protein. (406 aa)
ENSONIP00000031680Nuclear cap-binding protein subunit 2-like. (120 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C. (309 aa)
LOC100703764Cytotoxic granule-associated RNA binding protein 1, like. (391 aa)
LOC100692879Fibroblast growth factor binding protein 1b. (211 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (193 aa)
LOC100707861Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC100693787Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (154 aa)
fgf16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
fgf20bFibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC100707945Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (201 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
fgf20aFibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
rps27aRibosomal protein S27a. (156 aa)
Fgfbp3Fibroblast growth factor binding protein 3. (297 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
fgf7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (200 aa)
LOC100691488Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC100705713Serine/threonine-protein phosphatase. (311 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
hnrnpa1Heterogeneous nuclear ribonucleoprotein A1b. (332 aa)
LOC100699525Cbl proto-oncogene C, E3 ubiquitin protein ligase. (600 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
tial1TIA1 cytotoxic granule-associated RNA binding protein-like 1. (398 aa)
mknk2MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
I3JUL5_ORENIGRB2-associated binding protein 1. (777 aa)
LOC100692645Uncharacterized protein. (863 aa)
LOC100710677Uncharacterized protein. (538 aa)
SRCTyrosine-protein kinase. (550 aa)
LOC100707394PH domain-containing protein. (781 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
ppp2r1bProtein phosphatase 2, regulatory subunit A, beta b. (676 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
I3J6X6_ORENIFibroblast growth factor; Belongs to the heparin-binding growth factors family. (246 aa)
gtf2f2General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. (297 aa)
fgf22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (255 aa)
gtf2f1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (547 aa)
LOC100710281Serine/threonine-protein phosphatase. (309 aa)
I3J012_ORENIHeterogeneous nuclear ribonucleoprotein M. (679 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
I3IWZ7_ORENIPolypyrimidine tract binding protein 1a. (631 aa)
polr2jPolymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
polr2kDNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
polr2lDNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
ENSONIP00000078138PiggyBac transposable element-derived protein 4. (371 aa)
fndc3aFibronectin type III domain containing 3A. (1239 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
LOC100697722Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (398 aa)
ENSONIP00000075314annotation not available (120 aa)
ENSONIP00000074581PiggyBac transposable element-derived protein 4. (431 aa)
ENSONIP00000073729Fibroblast growth factor receptor substrate 2b. (500 aa)
esrp1Epithelial splicing regulatory protein 1. (749 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (182 aa)
PTBP3Polypyrimidine tract binding protein 3. (533 aa)
LOC100708453Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
LOC100702413Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (164 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1930 aa)
LOC100704516Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC100698788Fibroblast growth factor receptor substrate 3. (613 aa)
LOC100703836Zgc:55558. (250 aa)
grb2Growth factor receptor-bound protein 2b. (222 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
PTBP2Polypyrimidine tract binding protein 2a. (532 aa)
Fgfr2Fibroblast growth factor receptor. (865 aa)
LOC100692677Tyrosine-protein kinase. (593 aa)
LOC100711270MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (466 aa)
I3JG35_ORENICbl proto-oncogene, E3 ubiquitin protein ligase. (807 aa)
LOC100699171Epithelial splicing regulatory protein 2. (742 aa)
NCBP1Nuclear cap binding protein subunit 1. (816 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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