29 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (500 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
	ENSONIP00000002713	annotation not available (760 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)
	rfc1	Replication factor C subunit 1. (1169 aa)
	rfc5	Replication factor C (activator 1) 5. (341 aa)
	LOC100701531	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
	rfc2	Replication factor C (activator 1) 2. (361 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	polk	Polymerase (DNA directed) kappa. (875 aa)
	rpa2	Replication protein A2. (278 aa)
	LOC102079736	Uncharacterized protein. (966 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	Pold1	DNA polymerase. (1105 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
	pold4	DNA polymerase delta subunit 4. (107 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (571 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	LOC100697269	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa3	Replication protein A3. (122 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000002713	Pold1	ENSONIP00000002713	ENSONIP00000024391	annotation not available	DNA polymerase.	0.794
ENSONIP00000002713	RPA1	ENSONIP00000002713	ENSONIP00000027967	annotation not available	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.711
ENSONIP00000002713	meiob	ENSONIP00000002713	ENSONIP00000024921	annotation not available	Methionine sulfoxide reductase B1b.	0.711
ENSONIP00000002713	pcna	ENSONIP00000002713	ENSONIP00000070559	annotation not available	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.965
ENSONIP00000002713	pold2	ENSONIP00000002713	ENSONIP00000075122	annotation not available	Polymerase (DNA directed), delta 2, regulatory subunit.	0.691
ENSONIP00000002713	pold3	ENSONIP00000002713	ENSONIP00000018937	annotation not available	Polymerase (DNA-directed), delta 3, accessory subunit.	0.605
ENSONIP00000002713	pold4	ENSONIP00000002713	ENSONIP00000031245	annotation not available	DNA polymerase delta subunit 4.	0.474
ENSONIP00000002713	pole	ENSONIP00000002713	ENSONIP00000017005	annotation not available	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.865
ENSONIP00000002713	pole2	ENSONIP00000002713	ENSONIP00000081592	annotation not available	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.823
ENSONIP00000002713	pole3	ENSONIP00000002713	ENSONIP00000065492	annotation not available	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.756
ENSONIP00000002713	pole4	ENSONIP00000002713	ENSONIP00000002942	annotation not available	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.610
ENSONIP00000002713	polk	ENSONIP00000002713	ENSONIP00000020317	annotation not available	Polymerase (DNA directed) kappa.	0.652
ENSONIP00000002713	rfc1	ENSONIP00000002713	ENSONIP00000011300	annotation not available	Replication factor C subunit 1.	0.572
ENSONIP00000002713	rfc2	ENSONIP00000002713	ENSONIP00000018572	annotation not available	Replication factor C (activator 1) 2.	0.971
ENSONIP00000002713	rfc3	ENSONIP00000002713	ENSONIP00000015916	annotation not available	Replication factor C (activator 1) 3.	0.977
ENSONIP00000002713	rfc4	ENSONIP00000002713	ENSONIP00000024158	annotation not available	Replication factor C (activator 1) 4.	0.971
ENSONIP00000002713	rfc5	ENSONIP00000002713	ENSONIP00000013302	annotation not available	Replication factor C (activator 1) 5.	0.971
ENSONIP00000002713	rpa1	ENSONIP00000002713	ENSONIP00000069956	annotation not available	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.711
ENSONIP00000002713	rpa2	ENSONIP00000002713	ENSONIP00000020396	annotation not available	Replication protein A2.	0.566
ENSONIP00000002713	rpa3	ENSONIP00000002713	ENSONIP00000077053	annotation not available	Replication protein A3.	0.594