STRINGSTRING
LOC100709166 LOC100709166 rpa1 rpa1 pcna pcna ddb1 ddb1 sumo1 sumo1 parp1 parp1 pold2 pold2 cul4a cul4a rpa3 rpa3 pole2 pole2 Chd1l Chd1l rfc5 rfc5 LOC100696048 LOC100696048 vwa5b2 vwa5b2 rpap3 rpap3 rfc1 rfc1 ino80d ino80d rbx1 rbx1 ercc2 ercc2 rad23a rad23a ino80c ino80c rnf111 rnf111 nfrkb nfrkb gtf2h4 gtf2h4 LOC100701531 LOC100701531 rfc3 rfc3 uba52 uba52 ino80b ino80b LOC100692548 LOC100692548 gtf2h3 gtf2h3 cops2 cops2 pole pole LOC100704245 LOC100704245 rfc2 rfc2 kxd1 kxd1 RAD23B RAD23B pold3 pold3 Parp2 Parp2 pias1 pias1 Ddb2 Ddb2 rps27a rps27a polk polk rpa2 rpa2 xpa xpa LOC102079736 LOC102079736 kctd2 kctd2 parp3 parp3 ruvbl1 ruvbl1 rfc4 rfc4 Bivm Bivm Pold1 Pold1 meiob meiob LOC100703461 LOC100703461 mnat1 mnat1 RPA1 RPA1 cops4 cops4 LOC100712348 LOC100712348 ercc5 ercc5 ercc3 ercc3 ercc1 ercc1 Cul4b Cul4b ube2v2 ube2v2 pold4 pold4 I3JLC5_ORENI I3JLC5_ORENI LOC109202395 LOC109202395 gps1 gps1 LOC100690637 LOC100690637 LOC100696643 LOC100696643 wdr76 wdr76 cops8 cops8 pole4 pole4 LOC100708142 LOC100708142 ENSONIP00000002713 ENSONIP00000002713 actr5 actr5 actr8 actr8 xpc xpc LOC100695822 LOC100695822 YY1 YY1 ino80 ino80 usp45 usp45 ccnh ccnh RCBTB1 RCBTB1 mcrs1 mcrs1 cops5 cops5 ENSONIP00000047919 ENSONIP00000047919 tfpt tfpt LOC100697269 LOC100697269 ino80e ino80e COPS6 COPS6 cetn3 cetn3 ercc4 ercc4 actb actb cops3 cops3 cdk7 cdk7 LOC100699741 LOC100699741 gtf2h1 gtf2h1 ENSONIP00000061996 ENSONIP00000061996 sumo2 sumo2 ENSONIP00000064374 ENSONIP00000064374 pole3 pole3 gtf2h5 gtf2h5 LOC102083256 LOC102083256 ube2i ube2i LOC100692112 LOC100692112
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100709166Small ubiquitin-related modifier. (94 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ddb1Damage-specific DNA binding protein 1. (1140 aa)
sumo1Small ubiquitin-related modifier. (101 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1023 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (500 aa)
cul4aCullin 4A; Belongs to the cullin family. (819 aa)
rpa3Replication protein A3. (122 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
Chd1lChromodomain helicase DNA binding protein 1-like. (1013 aa)
rfc5Replication factor C (activator 1) 5. (341 aa)
LOC100696048General transcription factor IIH subunit. (392 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1401 aa)
rpap3RNA polymerase II associated protein 3. (663 aa)
rfc1Replication factor C subunit 1. (1169 aa)
ino80dINO80 complex subunit Da. (1005 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
rad23aRAD23 homolog A, nucleotide excision repair protein a. (365 aa)
ino80cINO80 complex subunit C. (203 aa)
rnf111Ring finger protein 111. (1006 aa)
nfrkbNuclear factor related to kappaB binding protein. (1274 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
LOC100701531Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
ino80bINO80 complex subunit B. (342 aa)
LOC100692548COP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (303 aa)
cops2COP9 signalosome subunit 2. (438 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
LOC100704245Uncharacterized protein. (407 aa)
rfc2Replication factor C (activator 1) 2. (361 aa)
kxd1KxDL motif containing 1. (184 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (369 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
Parp2Poly [ADP-ribose] polymerase. (619 aa)
pias1Protein inhibitor of activated STAT, 1b. (657 aa)
Ddb2Damage-specific DNA binding protein 2. (443 aa)
rps27aRibosomal protein S27a. (156 aa)
polkPolymerase (DNA directed) kappa. (875 aa)
rpa2Replication protein A2. (278 aa)
xpaXeroderma pigmentosum, complementation group A. (271 aa)
LOC102079736Uncharacterized protein. (966 aa)
kctd2Potassium channel tetramerization domain containing 2. (273 aa)
parp3Poly [ADP-ribose] polymerase. (539 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
BivmBasic, immunoglobulin-like variable motif containing. (518 aa)
Pold1DNA polymerase. (1105 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
LOC100703461YY1 transcription factor. (350 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
cops4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (421 aa)
LOC100712348Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family. (254 aa)
ercc5Excision repair cross-complementation group 5. (1111 aa)
ercc3Excision repair cross-complementation group 3. (802 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
Cul4bCullin-4B. (869 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (148 aa)
pold4DNA polymerase delta subunit 4. (107 aa)
I3JLC5_ORENIUncharacterized protein. (506 aa)
LOC109202395Small ubiquitin-related modifier 2. (145 aa)
gps1G protein pathway suppressor 1. (510 aa)
LOC100690637Small ubiquitin-related modifier. (94 aa)
LOC100696643Proline-, glutamic acid- and leucine-rich protein 1. (530 aa)
wdr76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (551 aa)
cops8COP9 signalosome subunit 8. (199 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)
LOC100708142SCY domain-containing protein. (126 aa)
ENSONIP00000002713annotation not available (760 aa)
actr5Actin related protein 5; Belongs to the actin family. (625 aa)
actr8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (643 aa)
xpcXeroderma pigmentosum, complementation group C. (930 aa)
LOC100695822Centrin 4. (171 aa)
YY1YY1 transcription factor b. (367 aa)
ino80INO80 complex ATPase subunit. (1573 aa)
usp45Ubiquitin carboxyl-terminal hydrolase. (823 aa)
ccnhCyclin H; Belongs to the cyclin family. (325 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (571 aa)
mcrs1Microspherule protein 1. (467 aa)
cops5COP9 signalosome subunit 5. (360 aa)
ENSONIP00000047919Ubiquitin B. (354 aa)
tfptTCF3 fusion partner isoform X3. (220 aa)
LOC100697269Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
ino80eINO80 complex subunit E. (237 aa)
COPS6COP9 signalosome subunit 6. (316 aa)
cetn3Centrin 3. (181 aa)
ercc4Excision repair cross-complementation group 4. (909 aa)
actbUncharacterized protein. (376 aa)
cops3COP9 signalosome subunit 3. (423 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa)
LOC100699741UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (138 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (556 aa)
ENSONIP00000061996annotation not available (157 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
ENSONIP00000064374Small ubiquitin-related modifier 2. (90 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
LOC102083256Si:ch73-290k24.6. (849 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
LOC100692112Protein inhibitor of activated STAT, 1a. (722 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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