47 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpa2	Replication protein A2. (278 aa)
	Chd1l	Chromodomain helicase DNA binding protein 1-like. (1013 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
	rpa3	Replication protein A3. (122 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (819 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (500 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1023 aa)
	ddb1	Damage-specific DNA binding protein 1. (1140 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (556 aa)
	ercc4	Excision repair cross-complementation group 4. (909 aa)
	LOC100697269	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (571 aa)
	pold4	DNA polymerase delta subunit 4. (107 aa)
	Cul4b	Cullin-4B. (869 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
	Pold1	DNA polymerase. (1105 aa)
	Bivm	Basic, immunoglobulin-like variable motif containing. (518 aa)
	rfc4	Replication factor C (activator 1) 4. (358 aa)
	parp3	Poly [ADP-ribose] polymerase. (539 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (271 aa)
	polk	Polymerase (DNA directed) kappa. (875 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	Ddb2	Damage-specific DNA binding protein 2. (443 aa)
	Parp2	Poly [ADP-ribose] polymerase. (619 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	rfc2	Replication factor C (activator 1) 2. (361 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (303 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	LOC100701531	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
	rfc5	Replication factor C (activator 1) 5. (341 aa)
	LOC100696048	General transcription factor IIH subunit. (392 aa)
	rfc1	Replication factor C subunit 1. (1169 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
	ercc1	Excision repair cross-complementation group 1. (352 aa)
	ercc3	Excision repair cross-complementation group 3. (802 aa)
	ercc5	Excision repair cross-complementation group 5. (1111 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Bivm	Chd1l	ENSONIP00000024339	ENSONIP00000081597	Basic, immunoglobulin-like variable motif containing.	Chromodomain helicase DNA binding protein 1-like.	0.702
Bivm	Cul4b	ENSONIP00000024339	ENSONIP00000030664	Basic, immunoglobulin-like variable motif containing.	Cullin-4B.	0.607
Bivm	Ddb2	ENSONIP00000024339	ENSONIP00000019498	Basic, immunoglobulin-like variable motif containing.	Damage-specific DNA binding protein 2.	0.706
Bivm	ENSONIP00000047919	ENSONIP00000024339	ENSONIP00000047919	Basic, immunoglobulin-like variable motif containing.	Ubiquitin B.	0.589
Bivm	LOC100696048	ENSONIP00000024339	ENSONIP00000013134	Basic, immunoglobulin-like variable motif containing.	General transcription factor IIH subunit.	0.883
Bivm	Parp2	ENSONIP00000024339	ENSONIP00000019125	Basic, immunoglobulin-like variable motif containing.	Poly [ADP-ribose] polymerase.	0.595
Bivm	Pold1	ENSONIP00000024339	ENSONIP00000024391	Basic, immunoglobulin-like variable motif containing.	DNA polymerase.	0.734
Bivm	RPA1	ENSONIP00000024339	ENSONIP00000027967	Basic, immunoglobulin-like variable motif containing.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.689
Bivm	cul4a	ENSONIP00000024339	ENSONIP00000076782	Basic, immunoglobulin-like variable motif containing.	Cullin 4A; Belongs to the cullin family.	0.607
Bivm	ddb1	ENSONIP00000024339	ENSONIP00000071715	Basic, immunoglobulin-like variable motif containing.	Damage-specific DNA binding protein 1.	0.765
Bivm	ercc1	ENSONIP00000024339	ENSONIP00000005206	Basic, immunoglobulin-like variable motif containing.	Excision repair cross-complementation group 1.	0.868
Bivm	ercc2	ENSONIP00000024339	ENSONIP00000009743	Basic, immunoglobulin-like variable motif containing.	Excision repair cross-complementation group 2.	0.943
Bivm	ercc3	ENSONIP00000024339	ENSONIP00000004087	Basic, immunoglobulin-like variable motif containing.	Excision repair cross-complementation group 3.	0.968
Bivm	ercc4	ENSONIP00000024339	ENSONIP00000052664	Basic, immunoglobulin-like variable motif containing.	Excision repair cross-complementation group 4.	0.887
Bivm	gtf2h1	ENSONIP00000024339	ENSONIP00000061516	Basic, immunoglobulin-like variable motif containing.	General transcription factor IIH, polypeptide 1.	0.954
Bivm	gtf2h3	ENSONIP00000024339	ENSONIP00000016648	Basic, immunoglobulin-like variable motif containing.	General transcription factor IIH, polypeptide 3.	0.717
Bivm	gtf2h4	ENSONIP00000024339	ENSONIP00000005972	Basic, immunoglobulin-like variable motif containing.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.662
Bivm	gtf2h5	ENSONIP00000024339	ENSONIP00000065995	Basic, immunoglobulin-like variable motif containing.	General transcription factor IIH, polypeptide 5.	0.722
Bivm	parp1	ENSONIP00000024339	ENSONIP00000074983	Basic, immunoglobulin-like variable motif containing.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.643
Bivm	parp3	ENSONIP00000024339	ENSONIP00000023905	Basic, immunoglobulin-like variable motif containing.	Poly [ADP-ribose] polymerase.	0.526