STRINGSTRING
pole2 pole2 polr2b polr2b polr2j polr2j I3IUQ0_ORENI I3IUQ0_ORENI I3IV18_ORENI I3IV18_ORENI usp40 usp40 ENSONIP00000002713 ENSONIP00000002713 LOC100708142 LOC100708142 pole4 pole4 COPS6 COPS6 ercc5 ercc5 ercc3 ercc3 ercc1 ercc1 gtf2h4 gtf2h4 polr2i polr2i xrcc1 xrcc1 ercc2 ercc2 rbx1 rbx1 rfc1 rfc1 ercc6 ercc6 phf3 phf3 LOC100696048 LOC100696048 rfc5 rfc5 uvssa uvssa LOC100701531 LOC100701531 rfc3 rfc3 uba52 uba52 LOC100692548 LOC100692548 gtf2h3 gtf2h3 cops2 cops2 pole pole ppp1r42 ppp1r42 rfc2 rfc2 kxd1 kxd1 pold3 pold3 I3KD07_ORENI I3KD07_ORENI usp7 usp7 rps27a rps27a polk polk rpa2 rpa2 xpa xpa LOC102079736 LOC102079736 rfc4 rfc4 Bivm Bivm Pold1 Pold1 I3KTW5_ORENI I3KTW5_ORENI meiob meiob mnat1 mnat1 TCEANC TCEANC ZNF830 ZNF830 RPA1 RPA1 cops4 cops4 polr2c polr2c Cul4b Cul4b pold4 pold4 lig3 lig3 gps1 gps1 POLR2E POLR2E tcea1 tcea1 ercc8 ercc8 cops8 cops8 ccnh ccnh RCBTB1 RCBTB1 prpf19 prpf19 cops5 cops5 xab2 xab2 polr2g polr2g ENSONIP00000047919 ENSONIP00000047919 polr2d polr2d LOC100697269 LOC100697269 aqr aqr ercc4 ercc4 ppie ppie polr2h polr2h cops3 cops3 cdk7 cdk7 I3JI35_ORENI I3JI35_ORENI gtf2h1 gtf2h1 polr2f polr2f pole3 pole3 gtf2h5 gtf2h5 rpa1 rpa1 pcna pcna polr2a polr2a ddb1 ddb1 LOC100698988 LOC100698988 tceanc2 tceanc2 pold2 pold2 LOC100700725 LOC100700725 cul4a cul4a rpa3 rpa3 polr2l polr2l polr2k polr2k
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
polr2jPolymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
I3IUQ0_ORENIISY1 splicing factor homolog. (250 aa)
I3IV18_ORENITranscription elongation factor A (SII), 2. (304 aa)
usp40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1290 aa)
ENSONIP00000002713annotation not available (760 aa)
LOC100708142SCY domain-containing protein. (126 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)
COPS6COP9 signalosome subunit 6. (316 aa)
ercc5Excision repair cross-complementation group 5. (1111 aa)
ercc3Excision repair cross-complementation group 3. (802 aa)
ercc1Excision repair cross-complementation group 1. (352 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (623 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
rfc1Replication factor C subunit 1. (1169 aa)
ercc6Excision repair cross-complementation group 6. (1437 aa)
phf3TFIIS central domain-containing protein. (1691 aa)
LOC100696048General transcription factor IIH subunit. (392 aa)
rfc5Replication factor C (activator 1) 5. (341 aa)
uvssaUV-stimulated scaffold protein A. (773 aa)
LOC100701531Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC100692548COP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (303 aa)
cops2COP9 signalosome subunit 2. (438 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
ppp1r42Protein phosphatase 1, regulatory subunit 42. (303 aa)
rfc2Replication factor C (activator 1) 2. (361 aa)
kxd1KxDL motif containing 1. (184 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
I3KD07_ORENIDNA ligase. (594 aa)
usp7Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1115 aa)
rps27aRibosomal protein S27a. (156 aa)
polkPolymerase (DNA directed) kappa. (875 aa)
rpa2Replication protein A2. (278 aa)
xpaXeroderma pigmentosum, complementation group A. (271 aa)
LOC102079736Uncharacterized protein. (966 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
BivmBasic, immunoglobulin-like variable motif containing. (518 aa)
Pold1DNA polymerase. (1105 aa)
I3KTW5_ORENINRDE-2, necessary for RNA interference, domain containing. (1130 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
TCEANCTranscription elongation factor A N-terminal and central domain containing. (311 aa)
ZNF830Zinc finger protein 830. (451 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
cops4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (421 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C. (309 aa)
Cul4bCullin-4B. (869 aa)
pold4DNA polymerase delta subunit 4. (107 aa)
lig3DNA ligase. (1037 aa)
gps1G protein pathway suppressor 1. (510 aa)
POLR2ERNA polymerase II subunit E. (249 aa)
tcea1Transcription elongation factor A (SII), 1. (344 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
cops8COP9 signalosome subunit 8. (199 aa)
ccnhCyclin H; Belongs to the cyclin family. (325 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (571 aa)
prpf19Pre-mRNA processing factor 19. (1489 aa)
cops5COP9 signalosome subunit 5. (360 aa)
xab2XPA binding protein 2. (854 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (181 aa)
ENSONIP00000047919Ubiquitin B. (354 aa)
polr2dPolymerase (RNA) II (DNA directed) polypeptide D. (509 aa)
LOC100697269Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
aqrAquarius intron-binding spliceosomal factor. (1473 aa)
ercc4Excision repair cross-complementation group 4. (909 aa)
ppiePeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (309 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
cops3COP9 signalosome subunit 3. (423 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa)
I3JI35_ORENITranscription elongation factor A (SII), 3. (423 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (556 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1930 aa)
ddb1Damage-specific DNA binding protein 1. (1140 aa)
LOC100698988E1A binding protein p300 a. (2777 aa)
tceanc2Uncharacterized protein. (207 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (500 aa)
LOC100700725E1A binding protein p300 b. (2799 aa)
cul4aCullin 4A; Belongs to the cullin family. (819 aa)
rpa3Replication protein A3. (122 aa)
polr2lDNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
polr2kDNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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