STRINGSTRING
pole2 pole2 polr2k polr2k polr2l polr2l rpa3 rpa3 cul4a cul4a LOC100700725 LOC100700725 pold2 pold2 tceanc2 tceanc2 LOC100698988 LOC100698988 ddb1 ddb1 polr2a polr2a pcna pcna rpa1 rpa1 gtf2h5 gtf2h5 pole3 pole3 polr2f polr2f gtf2h1 gtf2h1 I3JI35_ORENI I3JI35_ORENI cdk7 cdk7 polr2h polr2h ppie ppie aqr aqr LOC100697269 LOC100697269 polr2d polr2d ENSONIP00000047919 ENSONIP00000047919 polr2g polr2g xab2 xab2 prpf19 prpf19 RCBTB1 RCBTB1 ccnh ccnh ercc8 ercc8 tcea1 tcea1 POLR2E POLR2E lig3 lig3 pold4 pold4 Cul4b Cul4b polr2c polr2c RPA1 RPA1 ZNF830 ZNF830 TCEANC TCEANC mnat1 mnat1 meiob meiob I3KTW5_ORENI I3KTW5_ORENI Pold1 Pold1 rfc4 rfc4 LOC102079736 LOC102079736 rpa2 rpa2 polk polk rps27a rps27a usp7 usp7 I3KD07_ORENI I3KD07_ORENI pold3 pold3 kxd1 kxd1 rfc2 rfc2 pole pole gtf2h3 gtf2h3 uba52 uba52 rfc3 rfc3 LOC100701531 LOC100701531 uvssa uvssa rfc5 rfc5 LOC100696048 LOC100696048 phf3 phf3 ercc6 ercc6 rfc1 rfc1 rbx1 rbx1 ercc2 ercc2 xrcc1 xrcc1 polr2i polr2i gtf2h4 gtf2h4 ercc3 ercc3 pole4 pole4 ENSONIP00000002713 ENSONIP00000002713 usp40 usp40 I3IV18_ORENI I3IV18_ORENI I3IUQ0_ORENI I3IUQ0_ORENI polr2j polr2j polr2b polr2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (539 aa)
polr2kDNA-directed RNA polymerases I, II, and III subunit RPABC4. (58 aa)
polr2lDNA-directed RNA polymerases I, II, and III subunit RPABC5. (67 aa)
rpa3Replication protein A3. (122 aa)
cul4aCullin 4A; Belongs to the cullin family. (819 aa)
LOC100700725E1A binding protein p300 b. (2799 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (500 aa)
tceanc2Uncharacterized protein. (207 aa)
LOC100698988E1A binding protein p300 a. (2777 aa)
ddb1Damage-specific DNA binding protein 1. (1140 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1930 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (127 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (556 aa)
I3JI35_ORENITranscription elongation factor A (SII), 3. (423 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (347 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
ppiePeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (309 aa)
aqrAquarius intron-binding spliceosomal factor. (1473 aa)
LOC100697269Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (559 aa)
polr2dPolymerase (RNA) II (DNA directed) polypeptide D. (509 aa)
ENSONIP00000047919Ubiquitin B. (354 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (181 aa)
xab2XPA binding protein 2. (854 aa)
prpf19Pre-mRNA processing factor 19. (1489 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (571 aa)
ccnhCyclin H; Belongs to the cyclin family. (325 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
tcea1Transcription elongation factor A (SII), 1. (344 aa)
POLR2ERNA polymerase II subunit E. (249 aa)
lig3DNA ligase. (1037 aa)
pold4DNA polymerase delta subunit 4. (107 aa)
Cul4bCullin-4B. (869 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C. (309 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
ZNF830Zinc finger protein 830. (451 aa)
TCEANCTranscription elongation factor A N-terminal and central domain containing. (311 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
I3KTW5_ORENINRDE-2, necessary for RNA interference, domain containing. (1130 aa)
Pold1DNA polymerase. (1105 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
LOC102079736Uncharacterized protein. (966 aa)
rpa2Replication protein A2. (278 aa)
polkPolymerase (DNA directed) kappa. (875 aa)
rps27aRibosomal protein S27a. (156 aa)
usp7Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1115 aa)
I3KD07_ORENIDNA ligase. (594 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (447 aa)
kxd1KxDL motif containing 1. (184 aa)
rfc2Replication factor C (activator 1) 2. (361 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2292 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (303 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC100701531Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (591 aa)
uvssaUV-stimulated scaffold protein A. (773 aa)
rfc5Replication factor C (activator 1) 5. (341 aa)
LOC100696048General transcription factor IIH subunit. (392 aa)
phf3TFIIS central domain-containing protein. (1691 aa)
ercc6Excision repair cross-complementation group 6. (1437 aa)
rfc1Replication factor C subunit 1. (1169 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (107 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (623 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (479 aa)
ercc3Excision repair cross-complementation group 3. (802 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (128 aa)
ENSONIP00000002713annotation not available (760 aa)
usp40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1290 aa)
I3IV18_ORENITranscription elongation factor A (SII), 2. (304 aa)
I3IUQ0_ORENIISY1 splicing factor homolog. (250 aa)
polr2jPolymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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