STRINGSTRING
ENSONIP00000047919 ENSONIP00000047919 LOC100534434 LOC100534434 ENSONIP00000080735 ENSONIP00000080735 tbp tbp taf6 taf6 taf5 taf5 LOC100690588 LOC100690588 ENSONIP00000079103 ENSONIP00000079103 cdk2 cdk2 Pwwp2a Pwwp2a LOC100710852 LOC100710852 rpa3 rpa3 ENSONIP00000076285 ENSONIP00000076285 ENSONIP00000075614 ENSONIP00000075614 TAF4 TAF4 ENSONIP00000072645 ENSONIP00000072645 prkag1 prkag1 tpx2 tpx2 rpa1 rpa1 ENSONIP00000069434 ENSONIP00000069434 ENSONIP00000068885 ENSONIP00000068885 I3KPC9_ORENI I3KPC9_ORENI ENSONIP00000067613 ENSONIP00000067613 ENSONIP00000067528 ENSONIP00000067528 taf1 taf1 rad50 rad50 I3KS23_ORENI I3KS23_ORENI prkaa2 prkaa2 I3KLA6_ORENI I3KLA6_ORENI ENSONIP00000062235 ENSONIP00000062235 dyrk4 dyrk4 taf5l taf5l LOC100711637 LOC100711637 ENSONIP00000061540 ENSONIP00000061540 ENSONIP00000061534 ENSONIP00000061534 hus1 hus1 nuak1 nuak1 mapkapk5 mapkapk5 LOC100692416 LOC100692416 LOC100697765 LOC100697765 ENSONIP00000057645 ENSONIP00000057645 LOC100706117 LOC100706117 ENSONIP00000054453 ENSONIP00000054453 ENSONIP00000051045 ENSONIP00000051045 ENSONIP00000050163 ENSONIP00000050163 I3KSC7_ORENI I3KSC7_ORENI ENSONIP00000049587 ENSONIP00000049587 ENSONIP00000049112 ENSONIP00000049112 mre11 mre11 nuak2 nuak2 dna2 dna2 dyrk2 dyrk2 ENSONIP00000044148 ENSONIP00000044148 prkab1 prkab1 ENSONIP00000043492 ENSONIP00000043492 ENSONIP00000042300 ENSONIP00000042300 ENSONIP00000042112 ENSONIP00000042112 ENSONIP00000041826 ENSONIP00000041826 p53 p53 ENSONIP00000041212 ENSONIP00000041212 I3JMT1_ORENI I3JMT1_ORENI ENSONIP00000040630 ENSONIP00000040630 ENSONIP00000039619 ENSONIP00000039619 ENSONIP00000039009 ENSONIP00000039009 ENSONIP00000038409 ENSONIP00000038409 stk11 stk11 LOC109202667 LOC109202667 PRKAB2 PRKAB2 csnk2b csnk2b pin1 pin1 I3JW03_ORENI I3JW03_ORENI taf7l taf7l I3K7Y9_ORENI I3K7Y9_ORENI LOC102077672 LOC102077672 LOC100710911 LOC100710911 ENSONIP00000029324 ENSONIP00000029324 ssrp1 ssrp1 RPA1 RPA1 LOC100710962 LOC100710962 I3JTS5_ORENI I3JTS5_ORENI cdk5r2 cdk5r2 taf13 taf13 LOC102076274 LOC102076274 ENSONIP00000024927 ENSONIP00000024927 meiob meiob I3KTD2_ORENI I3KTD2_ORENI mdm4 mdm4 rfc4 rfc4 ankrd12 ankrd12 cdk5r1 cdk5r1 tp53inp2 tp53inp2 LOC100703206 LOC100703206 taf11 taf11 LOC100706350 LOC100706350 brca1 brca1 rpa2 rpa2 taf12 taf12 rps27a rps27a rad9b rad9b blm blm rmi1 rmi1 kxd1 kxd1 rfc2 rfc2 LOC100695096 LOC100695096 rad17 rad17 uba52 uba52 rfc3 rfc3 ccna1 ccna1 supt16h supt16h LOC100698859 LOC100698859 slf1 slf1 LOC100694821 LOC100694821 LOC100694808 LOC100694808 prkaa1 prkaa1 LOC100704877 LOC100704877 csnk2a2 csnk2a2 cdca7l cdca7l rfc5 rfc5 LOC100700904 LOC100700904 cdk5 cdk5 Exo1 Exo1 LOC100693447 LOC100693447 LOC100693588 LOC100693588 cdca7 cdca7 taf3 taf3 top3a top3a taf2 taf2 rad1 rad1 LOC100704251 LOC100704251 topbp1 topbp1 nbn nbn hipk3 hipk3 atm atm Kat5 Kat5 rad9a rad9a chek1 chek1 rbbp8 rbbp8 I3J6T4_ORENI I3J6T4_ORENI tdrd3 tdrd3 tp53rk tp53rk ankrd11 ankrd11 noc2l noc2l taf10 taf10 tp53inp1 tp53inp1 rmi2 rmi2 ccna2 ccna2 atr atr Chek2 Chek2 Atrip Atrip tbpl1 tbpl1 exd2 exd2 rhno1 rhno1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSONIP00000047919Ubiquitin B. (354 aa)
LOC100534434Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
ENSONIP00000080735annotation not available (540 aa)
tbpTATA box binding protein. (307 aa)
taf6Transcription initiation factor TFIID subunit 6. (695 aa)
taf5TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (792 aa)
LOC100690588Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (445 aa)
ENSONIP00000079103annotation not available (392 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (313 aa)
Pwwp2aPWWP domain containing 2A. (755 aa)
LOC100710852Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (393 aa)
rpa3Replication protein A3. (122 aa)
ENSONIP00000076285annotation not available (418 aa)
ENSONIP00000075614annotation not available (502 aa)
TAF4TATA-box binding protein associated factor 4. (991 aa)
ENSONIP00000072645annotation not available (456 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (427 aa)
tpx2TPX2 microtubule nucleation factor. (748 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (602 aa)
ENSONIP00000069434annotation not available (112 aa)
ENSONIP00000068885annotation not available (461 aa)
I3KPC9_ORENITAFH domain-containing protein. (301 aa)
ENSONIP00000067613annotation not available (348 aa)
ENSONIP00000067528Homeodomain interacting protein kinase. (434 aa)
taf1Transcription initiation factor TFIID subunit. (1991 aa)
rad50RAD50 homolog, double strand break repair protein. (1454 aa)
I3KS23_ORENIAAA_15 domain-containing protein. (1275 aa)
prkaa2Non-specific serine/threonine protein kinase. (577 aa)
I3KLA6_ORENIUncharacterized protein. (780 aa)
ENSONIP00000062235annotation not available (387 aa)
dyrk4Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4. (650 aa)
taf5lTAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor. (600 aa)
LOC100711637Dual specificity tyrosine phosphorylation regulated kinase 3. (604 aa)
ENSONIP00000061540annotation not available (241 aa)
ENSONIP00000061534annotation not available (580 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (301 aa)
nuak1NUAK family, SNF1-like kinase, 1b. (642 aa)
mapkapk5MAPK activated protein kinase 5. (511 aa)
LOC100692416Mitogen-activated protein kinase. (376 aa)
LOC100697765Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (379 aa)
ENSONIP00000057645annotation not available (386 aa)
LOC100706117Aurora kinase B; Belongs to the protein kinase superfamily. (290 aa)
ENSONIP00000054453annotation not available (371 aa)
ENSONIP00000051045annotation not available (389 aa)
ENSONIP00000050163annotation not available (363 aa)
I3KSC7_ORENIUncharacterized protein. (151 aa)
ENSONIP00000049587annotation not available (412 aa)
ENSONIP00000049112annotation not available (316 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (698 aa)
nuak2NUAK family, SNF1-like kinase, 2. (626 aa)
dna2DNA replication helicase/nuclease 2. (1463 aa)
dyrk2Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2. (592 aa)
ENSONIP00000044148annotation not available (371 aa)
prkab1Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (270 aa)
ENSONIP00000043492annotation not available (422 aa)
ENSONIP00000042300annotation not available (425 aa)
ENSONIP00000042112annotation not available (355 aa)
ENSONIP00000041826annotation not available (468 aa)
p53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
ENSONIP00000041212annotation not available (351 aa)
I3JMT1_ORENIDUF4806 domain-containing protein. (599 aa)
ENSONIP00000040630Uncharacterized protein LOC100704737 isoform X1. (474 aa)
ENSONIP00000039619annotation not available (325 aa)
ENSONIP00000039009annotation not available (341 aa)
ENSONIP00000038409annotation not available (370 aa)
stk11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (439 aa)
LOC109202667TAFH domain-containing protein. (1096 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (270 aa)
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (233 aa)
pin1Peptidyl-prolyl cis-trans isomerase. (156 aa)
I3JW03_ORENIHomeodomain interacting protein kinase 2. (1196 aa)
taf7lTAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (366 aa)
I3K7Y9_ORENICyclin-dependent kinase 5 activator. (362 aa)
LOC102077672Putative ankyrin repeat domain-containing protein 31 isoform X1. (673 aa)
LOC100710911Protein kinase domain-containing protein. (1380 aa)
ENSONIP00000029324annotation not available (378 aa)
ssrp1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (752 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (665 aa)
LOC100710962Casein kinase II subunit beta. (228 aa)
I3JTS5_ORENIProtein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (520 aa)
cdk5r2Cyclin-dependent kinase 5, regulatory subunit 2b (p39). (295 aa)
taf13TATA-box binding protein associated factor 13. (124 aa)
LOC102076274TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor. (291 aa)
ENSONIP00000024927RecQ helicase-like 4. (958 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
I3KTD2_ORENISi:ch211-160o17.4. (881 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (512 aa)
rfc4Replication factor C (activator 1) 4. (358 aa)
ankrd12Ankyrin repeat domain 12. (1954 aa)
cdk5r1Cyclin-dependent kinase 5 activator. (308 aa)
tp53inp2Tumor protein p53 inducible nuclear protein 2. (181 aa)
LOC100703206Uncharacterized protein. (312 aa)
taf11TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (204 aa)
LOC100706350Homeodomain interacting protein kinase 1a. (1142 aa)
brca1Uncharacterized protein. (1392 aa)
rpa2Replication protein A2. (278 aa)
taf12TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (162 aa)
rps27aRibosomal protein S27a. (156 aa)
rad9bRAD9 checkpoint clamp component B. (406 aa)
blmBLM RecQ like helicase. (1407 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (681 aa)
kxd1KxDL motif containing 1. (184 aa)
rfc2Replication factor C (activator 1) 2. (361 aa)
LOC100695096TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (261 aa)
rad17RAD17 checkpoint clamp loader component. (630 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (396 aa)
supt16hSPT16 homolog, facilitates chromatin remodeling subunit. (1109 aa)
LOC100698859Si:ch211-117c9.1. (705 aa)
slf1BRCT domain-containing protein. (885 aa)
LOC100694821TATA box binding protein like 2. (313 aa)
LOC100694808Aurora kinase A; Belongs to the protein kinase superfamily. (427 aa)
prkaa1Non-specific serine/threonine protein kinase. (580 aa)
LOC100704877Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (273 aa)
csnk2a2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (355 aa)
cdca7lCell division cycle associated 7b. (449 aa)
rfc5Replication factor C (activator 1) 5. (341 aa)
LOC100700904Mitogen-activated protein kinase. (365 aa)
cdk5Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
Exo1Exonuclease 1. (759 aa)
LOC100693447Mitogen-activated protein kinase. (364 aa)
LOC100693588Uncharacterized protein. (359 aa)
cdca7Cell division cycle associated 7a. (401 aa)
taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated facto. (886 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1037 aa)
taf2TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (1213 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
LOC100704251Cyclin-dependent kinase 5 activator. (327 aa)
topbp1DNA topoisomerase II binding protein 1. (1514 aa)
nbnNibrin. (840 aa)
hipk3Homeodomain interacting protein kinase 3b. (1313 aa)
atmNon-specific serine/threonine protein kinase. (3095 aa)
Kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (537 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (460 aa)
rbbp8Uncharacterized protein. (670 aa)
I3J6T4_ORENIRAD50 homolog, double strand break repair protein. (1260 aa)
tdrd3Tudor domain containing 3. (780 aa)
tp53rkTP53 regulating kinase. (236 aa)
ankrd11Ankyrin repeat domain 11. (2844 aa)
noc2lNOC2-like nucleolar associated transcriptional repressor. (750 aa)
taf10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (186 aa)
tp53inp1Tumor protein p53 inducible nuclear protein 1. (296 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2554 aa)
Chek2Checkpoint kinase 2. (482 aa)
AtripUncharacterized protein. (808 aa)
tbpl1TBP-like 1. (187 aa)
exd2Exonuclease 3'-5' domain containing 2. (640 aa)
rhno1Uncharacterized protein. (296 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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