42 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100702193	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (485 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (593 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (288 aa)
	daxx	Death-domain associated protein. (744 aa)
	p53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (313 aa)
	LOC100691860	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (486 aa)
	LOC100708948	USP domain-containing protein; Belongs to the peptidase C19 family. (602 aa)
	ENSONIP00000047919	Ubiquitin B. (354 aa)
	SGK1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (626 aa)
	LOC100695864	Ubiquitin carboxyl-terminal hydrolase. (439 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (336 aa)
	ENSONIP00000069434	annotation not available (112 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	LOC100691293	Ring finger protein 34b. (414 aa)
	ENSONIP00000000047	RAC-gamma serine/threonine-protein kinase. (487 aa)
	Chek2	Checkpoint kinase 2. (482 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (434 aa)
	LOC100710281	Serine/threonine-protein phosphatase. (309 aa)
	txndc11	Thioredoxin domain containing 11. (867 aa)
	LOC100707971	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	atm	Non-specific serine/threonine protein kinase. (3095 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (676 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (848 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2537 aa)
	Rictor	RPTOR independent companion of MTOR, complex 2 a. (1788 aa)
	rnf34	Ring finger protein 34a. (378 aa)
	mapkap1	MAPK associated protein 1. (529 aa)
	LOC100689746	Uncharacterized protein. (473 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (396 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC100705713	Serine/threonine-protein phosphatase. (311 aa)
	LOC100700828	PR domain containing 1b, with ZNF domain. (621 aa)
	LOC109194164	Uncharacterized protein. (784 aa)
	kxd1	KxDL motif containing 1. (184 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1115 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (512 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (327 aa)
	phf20	PHD finger protein 20, a. (1005 aa)
	I3KBQ6_ORENI	C2H2-type domain-containing protein. (98 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Chek2	ENSONIP00000047919	ENSONIP00000000942	ENSONIP00000047919	Checkpoint kinase 2.	Ubiquitin B.	0.530
Chek2	ENSONIP00000069434	ENSONIP00000000942	ENSONIP00000069434	Checkpoint kinase 2.	annotation not available	0.884
Chek2	LOC100705713	ENSONIP00000000942	ENSONIP00000016281	Checkpoint kinase 2.	Serine/threonine-protein phosphatase.	0.582
Chek2	LOC100710281	ENSONIP00000000942	ENSONIP00000002206	Checkpoint kinase 2.	Serine/threonine-protein phosphatase.	0.582
Chek2	atm	ENSONIP00000000942	ENSONIP00000006906	Checkpoint kinase 2.	Non-specific serine/threonine protein kinase.	0.996
Chek2	ccna1	ENSONIP00000000942	ENSONIP00000015894	Checkpoint kinase 2.	Cyclin A1; Belongs to the cyclin family.	0.497
Chek2	ccna2	ENSONIP00000000942	ENSONIP00000001689	Checkpoint kinase 2.	Cyclin A2; Belongs to the cyclin family.	0.603
Chek2	ccng1	ENSONIP00000000942	ENSONIP00000033946	Checkpoint kinase 2.	Cyclin G1; Belongs to the cyclin family.	0.482
Chek2	cdk1	ENSONIP00000000942	ENSONIP00000067132	Checkpoint kinase 2.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.462
Chek2	cdk2	ENSONIP00000000942	ENSONIP00000078153	Checkpoint kinase 2.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.462
Chek2	mdm4	ENSONIP00000000942	ENSONIP00000024311	Checkpoint kinase 2.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.791
Chek2	mtor	ENSONIP00000000942	ENSONIP00000011665	Checkpoint kinase 2.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.585
Chek2	p53	ENSONIP00000000942	ENSONIP00000041809	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.996
Chek2	ppp2ca	ENSONIP00000000942	ENSONIP00000021778	Checkpoint kinase 2.	Serine/threonine-protein phosphatase.	0.582
Chek2	rps27a	ENSONIP00000000942	ENSONIP00000020250	Checkpoint kinase 2.	Ribosomal protein S27a.	0.556
ENSONIP00000000047	ENSONIP00000069434	ENSONIP00000000047	ENSONIP00000069434	RAC-gamma serine/threonine-protein kinase.	annotation not available	0.744
ENSONIP00000000047	I3KBQ6_ORENI	ENSONIP00000000047	ENSONIP00000028095	RAC-gamma serine/threonine-protein kinase.	C2H2-type domain-containing protein.	0.429
ENSONIP00000000047	LOC100695864	ENSONIP00000000047	ENSONIP00000064036	RAC-gamma serine/threonine-protein kinase.	Ubiquitin carboxyl-terminal hydrolase.	0.403
ENSONIP00000000047	LOC100705713	ENSONIP00000000047	ENSONIP00000016281	RAC-gamma serine/threonine-protein kinase.	Serine/threonine-protein phosphatase.	0.570
ENSONIP00000000047	LOC100708948	ENSONIP00000000047	ENSONIP00000079920	RAC-gamma serine/threonine-protein kinase.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.403