STRINGSTRING
Chek2 Chek2 znf385c znf385c ccna2 ccna2 LOC100692568 LOC100692568 psmb3 psmb3 psmd14 psmd14 Ccne1 Ccne1 Psmb4 Psmb4 Psmd8 Psmd8 atm atm PSMA4 PSMA4 psmd12 psmd12 psme2 psme2 znf385b znf385b psma2 psma2 psmd5 psmd5 psme1 psme1 cdkn1b cdkn1b LOC100711644 LOC100711644 psma8 psma8 LOC100705995 LOC100705995 ccna1 ccna1 uba52 uba52 psmd9 psmd9 psmb2 psmb2 kxd1 kxd1 psmd7 psmd7 rps27a rps27a LOC100706998 LOC100706998 LOC100701743 LOC100701743 LOC100698501 LOC100698501 psmc3 psmc3 LOC100706559 LOC100706559 psme3 psme3 LOC102082412 LOC102082412 LOC100702076 LOC100702076 mdm4 mdm4 psmf1 psmf1 psma5 psma5 I3KUR8_ORENI I3KUR8_ORENI LOC100696839 LOC100696839 LOC100697106 LOC100697106 psmb8 psmb8 phf20 phf20 psmc4 psmc4 I3KBQ6_ORENI I3KBQ6_ORENI LOC100691978 LOC100691978 psmd1 psmd1 LOC102075526 LOC102075526 LOC100710977 LOC100710977 Psmd10 Psmd10 I3K295_ORENI I3K295_ORENI ENSONIP00000041766 ENSONIP00000041766 p53 p53 psmb1 psmb1 psmd3 psmd3 ENSONIP00000047919 ENSONIP00000047919 psmc6 psmc6 psma1 psma1 LOC102080582 LOC102080582 psmc5 psmc5 ENSONIP00000058178 ENSONIP00000058178 LOC100703282 LOC100703282 psma3 psma3 ENSONIP00000064494 ENSONIP00000064494 LOC100694980 LOC100694980 ENSONIP00000069434 ENSONIP00000069434 psme4 psme4 psma6 psma6 psmc1 psmc1 psmc2 psmc2 Pwwp2a Pwwp2a psmd6 psmd6 cdk2 cdk2 LOC100698550 LOC100698550 psmd13 psmd13 psmb7 psmb7 I3KG36_ORENI I3KG36_ORENI cop1 cop1 LOC100703712 LOC100703712
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Chek2Checkpoint kinase 2. (482 aa)
znf385cZinc finger protein 385C. (589 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
LOC100692568Cyclin E2; Belongs to the cyclin family. (397 aa)
psmb3Proteasome subunit beta. (205 aa)
psmd14Proteasome 26S subunit, non-ATPase 14. (333 aa)
Ccne1Cyclin E1; Belongs to the cyclin family. (296 aa)
Psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
Psmd8Proteasome 26S subunit, non-ATPase 8. (258 aa)
atmNon-specific serine/threonine protein kinase. (3095 aa)
PSMA4Proteasome subunit alpha type. (248 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
psme2Proteasome activator subunit 2. (245 aa)
znf385bC2H2-type domain-containing protein. (692 aa)
psma2Proteasome subunit alpha type. (234 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (524 aa)
psme1Proteasome activator subunit 1. (249 aa)
cdkn1bCyclin-dependent kinase inhibitor 1Bb. (184 aa)
LOC100711644Cyclin-dependent kinase inhibitor 1Cb. (209 aa)
psma8Proteasome subunit alpha type. (270 aa)
LOC100705995Proteasome subunit beta. (289 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (396 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (212 aa)
psmb2Proteasome subunit beta. (204 aa)
kxd1KxDL motif containing 1. (184 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (337 aa)
rps27aRibosomal protein S27a. (156 aa)
LOC100706998Uncharacterized protein. (558 aa)
LOC100701743Proteasome subunit alpha type. (246 aa)
LOC100698501Uncharacterized protein. (181 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (428 aa)
LOC100706559Proteasome 26S subunit, non-ATPase 11b. (424 aa)
psme3Proteasome activator subunit 3. (256 aa)
LOC102082412Cyclin-dependent kinase inhibitor 1A. (199 aa)
LOC100702076Uncharacterized protein. (429 aa)
mdm4MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (512 aa)
psmf1Proteasome inhibitor subunit 1. (326 aa)
psma5Proteasome subunit alpha type. (241 aa)
I3KUR8_ORENIProteasome 26S subunit, non-ATPase 4a. (393 aa)
LOC100696839Proteasome subunit beta. (217 aa)
LOC100697106Proteasome subunit beta 12. (217 aa)
psmb8Proteasome subunit beta. (275 aa)
phf20PHD finger protein 20, a. (1005 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
I3KBQ6_ORENIC2H2-type domain-containing protein. (98 aa)
LOC100691978Proteasome subunit alpha type. (256 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
LOC102075526Cyclin E2; Belongs to the cyclin family. (431 aa)
LOC100710977Proteasome subunit beta. (281 aa)
Psmd10Proteasome 26S subunit, non-ATPase 10. (228 aa)
I3K295_ORENIZinc finger protein 385A. (398 aa)
ENSONIP00000041766Cyclin-dependent kinase inhibitor 1B. (179 aa)
p53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
psmb1Proteasome subunit beta. (263 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (575 aa)
ENSONIP00000047919Ubiquitin B. (354 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (435 aa)
psma1Proteasome subunit alpha type. (263 aa)
LOC102080582Proteasome 26S subunit, non-ATPase 4b. (401 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (421 aa)
ENSONIP00000058178Proteasome subunit beta type-11-like. (305 aa)
LOC100703282Cyclin-dependent kinase inhibitor 1B. (168 aa)
psma3Proteasome subunit alpha type. (285 aa)
ENSONIP00000064494annotation not available (266 aa)
LOC100694980Proteasome subunit beta. (327 aa)
ENSONIP00000069434annotation not available (112 aa)
psme4Proteasome activator subunit 4a. (1847 aa)
psma6Proteasome 20S subunit alpha 6. (254 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (474 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (487 aa)
Pwwp2aPWWP domain containing 2A. (755 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (407 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (313 aa)
LOC100698550Proteasome subunit beta. (390 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (379 aa)
psmb7Proteasome subunit beta. (326 aa)
I3KG36_ORENIProteasome activator subunit 4b. (1840 aa)
cop1COP1 E3 ubiquitin ligase. (717 aa)
LOC100703712PCI domain-containing protein. (445 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.