(42 nodes) Nucleotide salvage network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ada	Adenosine deaminase. (396 aa)
	LOC100697636	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (791 aa)
	ADK	Adenosine kinase. (386 aa)
	pudp	Pseudouridine 5'-phosphatase. (298 aa)
	LOC100699839	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
	LOC100690403	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (311 aa)
	LOC100701068	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (226 aa)
	adal	Adenosine deaminase-like. (353 aa)
	upp2	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
	LOC100704213	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
	I3JYS4_ORENI	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (304 aa)
	dck	Deoxycytidine kinase. (263 aa)
	LOC100702364	GMP reductase 2. (361 aa)
	enkur	Enkurin, TRPC channel interacting protein. (261 aa)
	ENSONIP00000053847	annotation not available (194 aa)
	LOC100692415	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (949 aa)
	I3KMU1_ORENI	Zgc:110540. (285 aa)
	uck1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (282 aa)
	ampd1	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (745 aa)
	ampd3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (779 aa)
	LOC100697759	Zgc:174895. (200 aa)
	tk2	Thymidine kinase 2. (272 aa)
	LOC100705170	Deoxyguanosine kinase. (316 aa)
	LOC100698553	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (212 aa)
	LOC100707455	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (291 aa)
	I3KQN4_ORENI	Uridine-cytidine kinase; Belongs to the uridine kinase family. (268 aa)
	Tk1	Thymidine kinase. (244 aa)
	LOC100693679	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (401 aa)
	LOC100690200	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (295 aa)
	aprt	Adenine phosphoribosyltransferase. (181 aa)
	LOC100698935	Uridine-cytidine kinase; Belongs to the uridine kinase family. (262 aa)
	uckl1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (537 aa)
	LOC100693415	Adenosine kinase a. (374 aa)
	LOC100697655	Uridine-cytidine kinase; Belongs to the uridine kinase family. (580 aa)
	gmpr	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (357 aa)
	hprt1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	LOC100703583	Uridine-cytidine kinase; Belongs to the uridine kinase family. (550 aa)
	ENSONIP00000071933	annotation not available (163 aa)
	ENSONIP00000071939	Cytidine deaminase. (130 aa)
	LOC100709506	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (840 aa)
	TYMP	Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (479 aa)
	ENSONIP00000077782	Enkurin-like. (170 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	I3JYS4_ORENI	ENSONIP00000050544	ENSONIP00000014019	Adenosine kinase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.956
ADK	LOC100690200	ENSONIP00000050544	ENSONIP00000016459	Adenosine kinase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.956
ADK	LOC100690403	ENSONIP00000050544	ENSONIP00000003859	Adenosine kinase.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.677
ADK	LOC100692415	ENSONIP00000050544	ENSONIP00000055682	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.947
ADK	LOC100693415	ENSONIP00000050544	ENSONIP00000034679	Adenosine kinase.	Adenosine kinase a.	0.901
ADK	LOC100697636	ENSONIP00000050544	ENSONIP00000046209	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.947
ADK	LOC100697759	ENSONIP00000050544	ENSONIP00000016571	Adenosine kinase.	Zgc:174895.	0.654
ADK	LOC100699839	ENSONIP00000050544	ENSONIP00000000732	Adenosine kinase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.956
ADK	LOC100707455	ENSONIP00000050544	ENSONIP00000019071	Adenosine kinase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.956
ADK	LOC100709506	ENSONIP00000050544	ENSONIP00000072614	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.947
ADK	TYMP	ENSONIP00000050544	ENSONIP00000077763	Adenosine kinase.	Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.	0.769
ADK	ada	ENSONIP00000050544	ENSONIP00000064404	Adenosine kinase.	Adenosine deaminase.	0.974
ADK	adal	ENSONIP00000050544	ENSONIP00000010611	Adenosine kinase.	Adenosine deaminase-like.	0.624
ADK	ampd1	ENSONIP00000050544	ENSONIP00000066257	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.952
ADK	ampd3	ENSONIP00000050544	ENSONIP00000069866	Adenosine kinase.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.947
ADK	aprt	ENSONIP00000050544	ENSONIP00000041887	Adenosine kinase.	Adenine phosphoribosyltransferase.	0.964
ADK	pudp	ENSONIP00000050544	ENSONIP00000050732	Adenosine kinase.	Pseudouridine 5'-phosphatase.	0.419
ADK	tk2	ENSONIP00000050544	ENSONIP00000016530	Adenosine kinase.	Thymidine kinase 2.	0.444
ADK	upp2	ENSONIP00000050544	ENSONIP00000011260	Adenosine kinase.	Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.	0.677
ENSONIP00000053847	I3JYS4_ORENI	ENSONIP00000053847	ENSONIP00000014019	annotation not available	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.461