(59 nodes) RHOD GTPase cycle network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	WHAMM	WASP homolog associated with actin, golgi membranes and microtubules. (712 aa)
	LOC100702944	Uncharacterized protein. (499 aa)
	arhgap5	Rho GTPase activating protein 5. (1502 aa)
	I3J2P4_ORENI	Diaphanous-related formin 2. (1022 aa)
	golga2	Golgin A2. (1136 aa)
	CPNE9	Copine family member IX. (571 aa)
	I3J5A5_ORENI	Diaphanous-related formin 3. (1109 aa)
	LOC100697014	Uncharacterized protein. (430 aa)
	LOC100710886	Rho GTPase activating protein 35b. (1529 aa)
	LOC100691052	EF-hand domain family, member D1. (233 aa)
	vapb	VAMP (vesicle-associated membrane protein)-associated protein B and C. (242 aa)
	I3JLB3_ORENI	Rho GTPase activating protein 39. (1007 aa)
	LOC100708294	Non-specific serine/threonine protein kinase. (657 aa)
	LOC100698755	Filamin A interacting protein 1a. (1210 aa)
	cpne8	Copine 8. (564 aa)
	LOC100709543	CTTNBP2 N-terminal like a. (592 aa)
	LOC100708087	Extended synaptotagmin-like protein 1a. (983 aa)
	pak6	Non-specific serine/threonine protein kinase. (698 aa)
	LOC100696724	CTTNBP2 N-terminal like b. (588 aa)
	LOC100692045	RNA binding motif protein 39b. (498 aa)
	ankfy1	Ankyrin repeat and FYVE domain containing 1. (1176 aa)
	efhd2	EF-hand domain family, member D2. (233 aa)
	LOC100696183	Non-specific serine/threonine protein kinase. (632 aa)
	LOC100693947	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (165 aa)
	I3KSL0_ORENI	Si:ch1073-416j23.1. (397 aa)
	VAMP3	Vesicle associated membrane protein 3. (121 aa)
	LOC100704408	Uncharacterized protein. (634 aa)
	LOC100704392	Rho GTPase activating protein 17. (883 aa)
	LOC100701626	Zgc:92107. (1147 aa)
	LOC100696865	Uncharacterized protein. (311 aa)
	Vrk2	VRK serine/threonine kinase 2; Belongs to the protein kinase superfamily. (593 aa)
	LOC100699310	A kinase (PRKA) anchor protein 12b. (1506 aa)
	mospd2	Motile sperm domain containing 2. (552 aa)
	LOC100693200	Rho GTPase activating protein 17b. (900 aa)
	LOC102079346	Melanoma cell adhesion molecule a. (622 aa)
	DIAPH1	Diaphanous related formin 1. (1142 aa)
	LOC100693678	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
	lemd3	LEM domain containing 3. (844 aa)
	depdc1b	DEP domain containing 1B. (532 aa)
	LOC100694516	Copine-9. (566 aa)
	LOC102076290	Ras-related protein Rab-7A. (210 aa)
	LOC100704372	Ras homolog family member F. (208 aa)
	pgrmc2	Progesterone receptor membrane component 2; Belongs to the cytochrome b5 family. (198 aa)
	LOC100711250	Rho GTPase activating protein 21b. (1782 aa)
	pak5	Non-specific serine/threonine protein kinase. (767 aa)
	ENSONIP00000065651	Torsin-1A-interacting protein 2 isoform X1. (284 aa)
	ENSONIP00000067233	Copine VIII. (543 aa)
	I3KSL7_ORENI	Extended synaptotagmin-like protein 1b. (1644 aa)
	racgap1	Rac GTPase activating protein 1. (648 aa)
	arhgap21	Rho GTPase activating protein 21a. (2025 aa)
	ENSONIP00000072855	Uncharacterized protein LOC100691034. (154 aa)
	LOC100691877	Copine Va. (577 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	lman1	Lectin, mannose-binding, 1. (549 aa)
	stbd1	Starch-binding domain-containing protein 1. (892 aa)
	capzb	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (306 aa)
	VANGL1	Vang-like protein. (540 aa)
	filip1	Filamin A interacting protein 1b. (1194 aa)
	arhgap35	Uncharacterized protein. (1549 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPNE9	VAMP3	ENSONIP00000004021	ENSONIP00000024327	Copine family member IX.	Vesicle associated membrane protein 3.	0.411
CPNE9	capzb	ENSONIP00000004021	ENSONIP00000079320	Copine family member IX.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.406
DIAPH1	I3JLB3_ORENI	ENSONIP00000044242	ENSONIP00000009658	Diaphanous related formin 1.	Rho GTPase activating protein 39.	0.406
DIAPH1	LOC100697014	ENSONIP00000044242	ENSONIP00000004673	Diaphanous related formin 1.	Uncharacterized protein.	0.522
DIAPH1	LOC100701626	ENSONIP00000044242	ENSONIP00000025590	Diaphanous related formin 1.	Zgc:92107.	0.406
DIAPH1	LOC100704372	ENSONIP00000044242	ENSONIP00000050266	Diaphanous related formin 1.	Ras homolog family member F.	0.699
DIAPH1	VANGL1	ENSONIP00000044242	ENSONIP00000079425	Diaphanous related formin 1.	Vang-like protein.	0.401
DIAPH1	ankfy1	ENSONIP00000044242	ENSONIP00000022075	Diaphanous related formin 1.	Ankyrin repeat and FYVE domain containing 1.	0.504
DIAPH1	capzb	ENSONIP00000044242	ENSONIP00000079320	Diaphanous related formin 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.521
ENSONIP00000065651	LOC100704372	ENSONIP00000065651	ENSONIP00000050266	Torsin-1A-interacting protein 2 isoform X1.	Ras homolog family member F.	0.509
ENSONIP00000065651	VAMP3	ENSONIP00000065651	ENSONIP00000024327	Torsin-1A-interacting protein 2 isoform X1.	Vesicle associated membrane protein 3.	0.412
ENSONIP00000067233	VAMP3	ENSONIP00000067233	ENSONIP00000024327	Copine VIII.	Vesicle associated membrane protein 3.	0.411
ENSONIP00000067233	capzb	ENSONIP00000067233	ENSONIP00000079320	Copine VIII.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.406
I3J2P4_ORENI	I3JLB3_ORENI	ENSONIP00000003134	ENSONIP00000009658	Diaphanous-related formin 2.	Rho GTPase activating protein 39.	0.406
I3J2P4_ORENI	LOC100697014	ENSONIP00000003134	ENSONIP00000004673	Diaphanous-related formin 2.	Uncharacterized protein.	0.522
I3J2P4_ORENI	LOC100701626	ENSONIP00000003134	ENSONIP00000025590	Diaphanous-related formin 2.	Zgc:92107.	0.406
I3J2P4_ORENI	LOC100704372	ENSONIP00000003134	ENSONIP00000050266	Diaphanous-related formin 2.	Ras homolog family member F.	0.699
I3J2P4_ORENI	VANGL1	ENSONIP00000003134	ENSONIP00000079425	Diaphanous-related formin 2.	Vang-like protein.	0.401
I3J2P4_ORENI	ankfy1	ENSONIP00000003134	ENSONIP00000022075	Diaphanous-related formin 2.	Ankyrin repeat and FYVE domain containing 1.	0.504
I3J2P4_ORENI	capzb	ENSONIP00000003134	ENSONIP00000079320	Diaphanous-related formin 2.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.521