(35 nodes) Azathioprine ADME network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100693341	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (611 aa)
	I3JTG9_ORENI	GST N-terminal domain-containing protein. (336 aa)
	ENSONIP00000077782	Enkurin-like. (170 aa)
	slc28a1	Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (674 aa)
	LOC100691053	Solute carrier family 29 member 1a. (447 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (893 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (864 aa)
	LOC100701068	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (226 aa)
	LOC100704213	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (225 aa)
	LOC100701074	Uncharacterized protein. (1340 aa)
	LOC100698553	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (212 aa)
	LOC100710729	Solute carrier family 29 member 2. (433 aa)
	LOC100691909	Vav 3 guanine nucleotide exchange factor b. (843 aa)
	SLC28A3	Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family. (627 aa)
	guk1	Guanylate kinase 1a. (207 aa)
	ABCC4	ATP binding cassette subfamily C member 4. (1286 aa)
	LOC100707189	Uncharacterized protein. (366 aa)
	gsta	Glutathione S-transferase. (222 aa)
	LOC100696772	NME/NM23 nucleoside diphosphate kinase 2a; Belongs to the NDK family. (152 aa)
	LOC100702162	ATP-binding cassette, sub-family C (CFTR/MRP), member 4. (1359 aa)
	hprt1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
	LOC100704394	Uncharacterized protein. (432 aa)
	gmps	Guanine monophosphate synthase. (704 aa)
	setbp1	SET-binding protein. (1374 aa)
	dalrd3	DALR anticodon binding domain containing 3. (617 aa)
	enkur	Enkurin, TRPC channel interacting protein. (261 aa)
	nudt15	Nucleotide triphosphate diphosphatase NUDT15. (150 aa)
	ENSONIP00000053847	annotation not available (194 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (869 aa)
	LOC100701529	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (625 aa)
	LOC100707138	Solute carrier family 29 member 2. (478 aa)
	ENSONIP00000071933	annotation not available (163 aa)
	impdh2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (565 aa)
	LOC100701070	Guanylate kinase 1b. (261 aa)
	ENSONIP00000076806	annotation not available (163 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
I3JTG9_ORENI	gsta	ENSONIP00000077302	ENSONIP00000035864	GST N-terminal domain-containing protein.	Glutathione S-transferase.	0.653
LOC100693341	LOC100698553	ENSONIP00000050245	ENSONIP00000018682	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.925
LOC100693341	LOC100701529	ENSONIP00000050245	ENSONIP00000058675	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.900
LOC100693341	LOC100707189	ENSONIP00000050245	ENSONIP00000032169	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Uncharacterized protein.	0.916
LOC100693341	gmps	ENSONIP00000050245	ENSONIP00000046462	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Guanine monophosphate synthase.	0.993
LOC100693341	hprt1	ENSONIP00000050245	ENSONIP00000043675	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.925
LOC100693341	impdh2	ENSONIP00000050245	ENSONIP00000073439	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.938
LOC100696772	LOC100701070	ENSONIP00000042960	ENSONIP00000074400	NME/NM23 nucleoside diphosphate kinase 2a; Belongs to the NDK family.	Guanylate kinase 1b.	0.930
LOC100696772	guk1	ENSONIP00000042960	ENSONIP00000031220	NME/NM23 nucleoside diphosphate kinase 2a; Belongs to the NDK family.	Guanylate kinase 1a.	0.930
LOC100696772	nudt15	ENSONIP00000042960	ENSONIP00000052937	NME/NM23 nucleoside diphosphate kinase 2a; Belongs to the NDK family.	Nucleotide triphosphate diphosphatase NUDT15.	0.424
LOC100698553	LOC100693341	ENSONIP00000018682	ENSONIP00000050245	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.925
LOC100698553	LOC100701070	ENSONIP00000018682	ENSONIP00000074400	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanylate kinase 1b.	0.920
LOC100698553	LOC100701529	ENSONIP00000018682	ENSONIP00000058675	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.925
LOC100698553	LOC100707189	ENSONIP00000018682	ENSONIP00000032169	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Uncharacterized protein.	0.909
LOC100698553	gmps	ENSONIP00000018682	ENSONIP00000046462	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanine monophosphate synthase.	0.936
LOC100698553	guk1	ENSONIP00000018682	ENSONIP00000031220	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanylate kinase 1a.	0.920
LOC100698553	hprt1	ENSONIP00000018682	ENSONIP00000043675	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.901
LOC100698553	impdh2	ENSONIP00000018682	ENSONIP00000073439	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.	0.925
LOC100701068	LOC100701070	ENSONIP00000008134	ENSONIP00000074400	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanylate kinase 1b.	0.670
LOC100701068	guk1	ENSONIP00000008134	ENSONIP00000031220	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	Guanylate kinase 1a.	0.649