(8 nodes) (2019) Antioxidative, anti-inflammatory and hepatoprotective effects of resveratrol on oxidative stress-induced liver damage in tilapia (Oreochromis niloticus). network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100534578	Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
	myd88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (288 aa)
	LOC100707066	Interleukin-1. (244 aa)
	TLR2	Uncharacterized protein. (787 aa)
	TLR2-2	Toll-like receptor 2 isoform X1. (786 aa)
	il10	Interleukin 10. (275 aa)
	tlr2	TIR domain-containing protein. (821 aa)
	TLR2-3	Toll-like receptor 2. (670 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100534578	LOC100707066	ENSONIP00000002809	ENSONIP00000010489	Tumor necrosis factor b (TNF superfamily, member 2).	Interleukin-1.	0.953
LOC100534578	TLR2	ENSONIP00000002809	ENSONIP00000025925	Tumor necrosis factor b (TNF superfamily, member 2).	Uncharacterized protein.	0.438
LOC100534578	TLR2-2	ENSONIP00000002809	ENSONIP00000029726	Tumor necrosis factor b (TNF superfamily, member 2).	Toll-like receptor 2 isoform X1.	0.461
LOC100534578	TLR2-3	ENSONIP00000002809	ENSONIP00000054439	Tumor necrosis factor b (TNF superfamily, member 2).	Toll-like receptor 2.	0.446
LOC100534578	il10	ENSONIP00000002809	ENSONIP00000038761	Tumor necrosis factor b (TNF superfamily, member 2).	Interleukin 10.	0.874
LOC100534578	myd88	ENSONIP00000002809	ENSONIP00000007350	Tumor necrosis factor b (TNF superfamily, member 2).	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.774
LOC100534578	tlr2	ENSONIP00000002809	ENSONIP00000044084	Tumor necrosis factor b (TNF superfamily, member 2).	TIR domain-containing protein.	0.438
LOC100707066	LOC100534578	ENSONIP00000010489	ENSONIP00000002809	Interleukin-1.	Tumor necrosis factor b (TNF superfamily, member 2).	0.953
LOC100707066	TLR2	ENSONIP00000010489	ENSONIP00000025925	Interleukin-1.	Uncharacterized protein.	0.668
LOC100707066	TLR2-2	ENSONIP00000010489	ENSONIP00000029726	Interleukin-1.	Toll-like receptor 2 isoform X1.	0.597
LOC100707066	TLR2-3	ENSONIP00000010489	ENSONIP00000054439	Interleukin-1.	Toll-like receptor 2.	0.597
LOC100707066	il10	ENSONIP00000010489	ENSONIP00000038761	Interleukin-1.	Interleukin 10.	0.948
LOC100707066	myd88	ENSONIP00000010489	ENSONIP00000007350	Interleukin-1.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.917
LOC100707066	tlr2	ENSONIP00000010489	ENSONIP00000044084	Interleukin-1.	TIR domain-containing protein.	0.668
TLR2	LOC100534578	ENSONIP00000025925	ENSONIP00000002809	Uncharacterized protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.438
TLR2	LOC100707066	ENSONIP00000025925	ENSONIP00000010489	Uncharacterized protein.	Interleukin-1.	0.668
TLR2	il10	ENSONIP00000025925	ENSONIP00000038761	Uncharacterized protein.	Interleukin 10.	0.632
TLR2	myd88	ENSONIP00000025925	ENSONIP00000007350	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.980
TLR2-2	LOC100534578	ENSONIP00000029726	ENSONIP00000002809	Toll-like receptor 2 isoform X1.	Tumor necrosis factor b (TNF superfamily, member 2).	0.461
TLR2-2	LOC100707066	ENSONIP00000029726	ENSONIP00000010489	Toll-like receptor 2 isoform X1.	Interleukin-1.	0.597