(35 nodes) (2021) Function of Circular RNAs in Fish and Their Potential Application as Biomarkers. network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	MBNL2	Muscleblind like splicing regulator 2. (399 aa)
	Hsp90ab1	Heat shock protein 90, alpha (cytosolic), class B member 1. (752 aa)
	LOC100712433	Muscleblind-like splicing regulator 1. (407 aa)
	LOC100703985	HP domain-containing protein. (2399 aa)
	LOC109204785	Cyclic GMP-AMP synthase. (627 aa)
	LOC100708747	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (903 aa)
	qki	QKI, KH domain containing, RNA binding 2. (349 aa)
	LOC102078106	Cyclic GMP-AMP synthase. (511 aa)
	LOC100711983	Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family. (1058 aa)
	ythdf2	YTH N(6)-methyladenosine RNA binding protein 2. (638 aa)
	Svil	Supervillin a. (2303 aa)
	ccnd1	Cyclin D1; Belongs to the cyclin family. (292 aa)
	LOC102075526	Cyclin E2; Belongs to the cyclin family. (431 aa)
	myog	Myogenin. (262 aa)
	mstn	Myostatin b. (376 aa)
	LOC100691532	Muscleblind-like splicing regulator 3. (365 aa)
	MBNL1	Muscleblind like splicing regulator 1. (416 aa)
	Tmem176b	Uncharacterized protein. (237 aa)
	ampd3	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (779 aa)
	HSPA8	Uncharacterized protein. (664 aa)
	LOC100695201	Muscleblind-like splicing regulator 2. (389 aa)
	LOC100695663	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC100689828	Supervillin isoform X1. (1516 aa)
	myf5	Myogenic factor. (241 aa)
	adar	Adenosine deaminase RNA specific. (1363 aa)
	LOC100694851	Supervillin c. (1655 aa)
	LOC100702954	Interferon regulatory factor 3. (466 aa)
	LOC100708356	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (233 aa)
	KAT6B	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (872 aa)
	mavs	CARD_2 domain-containing protein. (552 aa)
	SRF	Serum response factor. (597 aa)
	hipk3	Homeodomain interacting protein kinase 3b. (1313 aa)
	hspa13	Heat shock protein 70 family, member 13. (479 aa)
	LOC100692568	Cyclin E2; Belongs to the cyclin family. (397 aa)
	myf6	Myogenic factor 6. (225 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSPA8	Hsp90ab1	ENSONIP00000076184	ENSONIP00000032806	Uncharacterized protein.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.873
HSPA8	hspa13	ENSONIP00000076184	ENSONIP00000006547	Uncharacterized protein.	Heat shock protein 70 family, member 13.	0.502
Hsp90ab1	HSPA8	ENSONIP00000032806	ENSONIP00000076184	Heat shock protein 90, alpha (cytosolic), class B member 1.	Uncharacterized protein.	0.873
Hsp90ab1	LOC100702954	ENSONIP00000032806	ENSONIP00000025281	Heat shock protein 90, alpha (cytosolic), class B member 1.	Interferon regulatory factor 3.	0.591
Hsp90ab1	LOC100708747	ENSONIP00000032806	ENSONIP00000046751	Heat shock protein 90, alpha (cytosolic), class B member 1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.401
Hsp90ab1	hspa13	ENSONIP00000032806	ENSONIP00000006547	Heat shock protein 90, alpha (cytosolic), class B member 1.	Heat shock protein 70 family, member 13.	0.824
KAT6B	ampd3	ENSONIP00000020390	ENSONIP00000069866	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.	0.487
LOC100689828	LOC100692568	ENSONIP00000080733	ENSONIP00000001872	Supervillin isoform X1.	Cyclin E2; Belongs to the cyclin family.	0.491
LOC100689828	LOC100708356	ENSONIP00000080733	ENSONIP00000022677	Supervillin isoform X1.	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events.	0.530
LOC100689828	LOC100708747	ENSONIP00000080733	ENSONIP00000046751	Supervillin isoform X1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.472
LOC100689828	LOC102075526	ENSONIP00000080733	ENSONIP00000032266	Supervillin isoform X1.	Cyclin E2; Belongs to the cyclin family.	0.488
LOC100689828	SRF	ENSONIP00000080733	ENSONIP00000012780	Supervillin isoform X1.	Serum response factor.	0.424
LOC100689828	Tmem176b	ENSONIP00000080733	ENSONIP00000069259	Supervillin isoform X1.	Uncharacterized protein.	0.487
LOC100692568	LOC100689828	ENSONIP00000001872	ENSONIP00000080733	Cyclin E2; Belongs to the cyclin family.	Supervillin isoform X1.	0.491
LOC100692568	LOC100694851	ENSONIP00000001872	ENSONIP00000028537	Cyclin E2; Belongs to the cyclin family.	Supervillin c.	0.488
LOC100692568	LOC100703985	ENSONIP00000001872	ENSONIP00000038277	Cyclin E2; Belongs to the cyclin family.	HP domain-containing protein.	0.528
LOC100692568	LOC100708356	ENSONIP00000001872	ENSONIP00000022677	Cyclin E2; Belongs to the cyclin family.	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events.	0.557
LOC100692568	LOC102075526	ENSONIP00000001872	ENSONIP00000032266	Cyclin E2; Belongs to the cyclin family.	Cyclin E2; Belongs to the cyclin family.	0.907
LOC100692568	Svil	ENSONIP00000001872	ENSONIP00000052839	Cyclin E2; Belongs to the cyclin family.	Supervillin a.	0.512
LOC100692568	Tmem176b	ENSONIP00000001872	ENSONIP00000069259	Cyclin E2; Belongs to the cyclin family.	Uncharacterized protein.	0.480