(32 nodes) (2023) TGF-beta1 suppresses the T-cell response in teleost fish by initiating Smad3- and Foxp3-mediated transcriptional networks. network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	LOC100702560	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (274 aa)
	ENSONIP00000005595	Granzyme-like protein 1 isoform X1. (253 aa)
	I3J946_ORENI	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (255 aa)
	HNRNPUL1	Heterogeneous nuclear ribonucleoprotein U like 1. (867 aa)
	LOC100692779	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (286 aa)
	LOC100691973	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (290 aa)
	I3JLC0_ORENI	Interferon regulatory factor 2 binding protein 1. (433 aa)
	LOC100691703	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (285 aa)
	TYR	Tyrosinase. (555 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	LOC100697584	Galectin. (366 aa)
	furin	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family. (843 aa)
	LOC102082461	Mast cell protease 1A. (266 aa)
	LOC100696446	Tyrosine-protein kinase. (634 aa)
	egr1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (514 aa)
	ENSONIP00000036217	Histone H3. (165 aa)
	il10	Interleukin 10. (275 aa)
	LOC100693160	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (238 aa)
	LOC100702133	Forkhead box A3. (466 aa)
	LOC100707066	Interleukin-1. (244 aa)
	irf4	Interferon regulatory factor 4a. (460 aa)
	LOC100705046	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family. (812 aa)
	LOC100700684	Galectin. (229 aa)
	smad3	Mothers against decapentaplegic homolog. (448 aa)
	LOC100710325	Mothers against decapentaplegic homolog. (467 aa)
	gata3	GATA binding protein 3. (443 aa)
	LOC100706816	Galectin-3 isoform X2. (376 aa)
	LOC100691280	Histone H3; Belongs to the histone H3 family. (136 aa)
	foxp1	Forkhead box P1. (679 aa)
	LOC100694027	G protein-coupled receptor 173. (394 aa)
	foxp3	Fork-head domain-containing protein. (390 aa)
	LOC100702374	Interferon regulatory factor 2 binding protein 1. (574 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000036217	gata3	ENSONIP00000036217	ENSONIP00000022592	Histone H3.	GATA binding protein 3.	0.418
LOC100691280	gata3	ENSONIP00000025156	ENSONIP00000022592	Histone H3; Belongs to the histone H3 family.	GATA binding protein 3.	0.418
LOC100696446	LOC100705046	ENSONIP00000062031	ENSONIP00000051758	Tyrosine-protein kinase.	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	0.404
LOC100696446	furin	ENSONIP00000062031	ENSONIP00000051905	Tyrosine-protein kinase.	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.	0.404
LOC100702133	gata3	ENSONIP00000040302	ENSONIP00000022592	Forkhead box A3.	GATA binding protein 3.	0.529
LOC100705046	LOC100696446	ENSONIP00000051758	ENSONIP00000062031	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Tyrosine-protein kinase.	0.404
LOC100707066	LOC100710325	ENSONIP00000010489	ENSONIP00000020038	Interleukin-1.	Mothers against decapentaplegic homolog.	0.586
LOC100707066	SMAD3	ENSONIP00000010489	ENSONIP00000071836	Interleukin-1.	Mothers against decapentaplegic homolog.	0.586
LOC100707066	il10	ENSONIP00000010489	ENSONIP00000038761	Interleukin-1.	Interleukin 10.	0.948
LOC100707066	smad3	ENSONIP00000010489	ENSONIP00000019456	Interleukin-1.	Mothers against decapentaplegic homolog.	0.586
LOC100710325	LOC100707066	ENSONIP00000020038	ENSONIP00000010489	Mothers against decapentaplegic homolog.	Interleukin-1.	0.586
LOC100710325	SMAD3	ENSONIP00000020038	ENSONIP00000071836	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
SMAD3	LOC100707066	ENSONIP00000071836	ENSONIP00000010489	Mothers against decapentaplegic homolog.	Interleukin-1.	0.586
SMAD3	LOC100710325	ENSONIP00000071836	ENSONIP00000020038	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.901
foxp3	gata3	ENSONIP00000049270	ENSONIP00000022592	Fork-head domain-containing protein.	GATA binding protein 3.	0.559
foxp3	il10	ENSONIP00000049270	ENSONIP00000038761	Fork-head domain-containing protein.	Interleukin 10.	0.671
furin	LOC100696446	ENSONIP00000051905	ENSONIP00000062031	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.	Tyrosine-protein kinase.	0.404
gata3	ENSONIP00000036217	ENSONIP00000022592	ENSONIP00000036217	GATA binding protein 3.	Histone H3.	0.418
gata3	LOC100691280	ENSONIP00000022592	ENSONIP00000025156	GATA binding protein 3.	Histone H3; Belongs to the histone H3 family.	0.418
gata3	LOC100702133	ENSONIP00000022592	ENSONIP00000040302	GATA binding protein 3.	Forkhead box A3.	0.529