46 items (Oreochromis niloticus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100707265	Retinol dehydrogenase 8a; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (317 aa)
	I3IZP7_ORENI	Zmp:0000001048; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (324 aa)
	SPPL2A	Signal peptide peptidase like 2A. (538 aa)
	LOC100710041	Ribonucleotide reductase M2 b. (379 aa)
	LOC100704840	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	GCDH	Glutaryl-CoA dehydrogenase b. (446 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2537 aa)
	pars2	Prolyl-tRNA synthetase 2, mitochondrial. (483 aa)
	iars2	Isoleucyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1014 aa)
	pgk1	Phosphoglycerate kinase. (417 aa)
	I3KPD3_ORENI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (552 aa)
	LOC100534494	Alpha-amylase. (518 aa)
	I3KRC2_ORENI	Uncharacterized protein. (407 aa)
	RRM2	Ribonucleotide reductase regulatory subunit M2. (406 aa)
	LOC100693336	Zgc:109982; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (315 aa)
	gclc	Glutamate-cysteine ligase, catalytic subunit. (639 aa)
	COX1	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (531 aa)
	kars1	Lysine--tRNA ligase. (608 aa)
	LOC100694159	Hexokinase 2. (937 aa)
	LOC112841648	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	LOC100704022	Tubulin alpha chain-like. (499 aa)
	LOC100701127	Glutaryl-CoA dehydrogenase a. (443 aa)
	LOC100708633	Carboxypeptidase A1 (pancreatic). (455 aa)
	LOC109194289	Alpha-amylase. (511 aa)
	LOC100694900	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (813 aa)
	LOC100534543	Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
	LOC100694867	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (501 aa)
	LOC100695265	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	iars	Isoleucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (1295 aa)
	HK1	Hexokinase 1. (970 aa)
	LOC109197098	Tubulin alpha-1A chain isoform X1. (560 aa)
	TUBA4A	Tubulin, alpha 8 like 2; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (577 aa)
	hadhb	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (480 aa)
	LOC109194398	Tubulin alpha chain-like. (473 aa)
	LOC100698696	Acyl-CoA dehydrogenase long chain. (443 aa)
	CYTB	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
	I3JH18_ORENI	Pyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
	tpi	Triosephosphate isomerase. (247 aa)
	LOC100706008	Zgc:77938. (385 aa)
	pkm	Pyruvate kinase; Belongs to the pyruvate kinase family. (596 aa)
	LOC109197651	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (545 aa)
	LOC100695823	S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (395 aa)
	rdh8	Retinol dehydrogenase 8b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (339 aa)
	TUBA1B	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (476 aa)
	LOC100696029	Triosephosphate isomerase. (248 aa)
	Sec13	SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (326 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COX1	CYTB	ENSONIP00000032108	ENSONIP00000061682	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	0.999
COX1	I3KPD3_ORENI	ENSONIP00000032108	ENSONIP00000022978	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.467
COX1	LOC100696029	ENSONIP00000032108	ENSONIP00000080720	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Triosephosphate isomerase.	0.569
COX1	LOC100704840	ENSONIP00000032108	ENSONIP00000003599	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.467
COX1	tpi	ENSONIP00000032108	ENSONIP00000065668	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	Triosephosphate isomerase.	0.569
CYTB	COX1	ENSONIP00000061682	ENSONIP00000032108	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.	0.999
CYTB	LOC100696029	ENSONIP00000061682	ENSONIP00000080720	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Triosephosphate isomerase.	0.404
CYTB	tpi	ENSONIP00000061682	ENSONIP00000065668	Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.	Triosephosphate isomerase.	0.404
GCDH	LOC100701127	ENSONIP00000010164	ENSONIP00000037553	Glutaryl-CoA dehydrogenase b.	Glutaryl-CoA dehydrogenase a.	0.900
GCDH	hadhb	ENSONIP00000010164	ENSONIP00000052738	Glutaryl-CoA dehydrogenase b.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.606
HK1	I3JH18_ORENI	ENSONIP00000046818	ENSONIP00000064832	Hexokinase 1.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.642
HK1	I3KPD3_ORENI	ENSONIP00000046818	ENSONIP00000022978	Hexokinase 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.964
HK1	LOC100534543	ENSONIP00000046818	ENSONIP00000041402	Hexokinase 1.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.586
HK1	LOC100694159	ENSONIP00000046818	ENSONIP00000033188	Hexokinase 1.	Hexokinase 2.	0.902
HK1	LOC100704840	ENSONIP00000046818	ENSONIP00000003599	Hexokinase 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.964
HK1	pgk1	ENSONIP00000046818	ENSONIP00000021862	Hexokinase 1.	Phosphoglycerate kinase.	0.469
HK1	pkm	ENSONIP00000046818	ENSONIP00000070522	Hexokinase 1.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.646
I3JH18_ORENI	HK1	ENSONIP00000064832	ENSONIP00000046818	Pyruvate kinase; Belongs to the pyruvate kinase family.	Hexokinase 1.	0.642
I3JH18_ORENI	I3KPD3_ORENI	ENSONIP00000064832	ENSONIP00000022978	Pyruvate kinase; Belongs to the pyruvate kinase family.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.950
I3JH18_ORENI	I3KRC2_ORENI	ENSONIP00000064832	ENSONIP00000023667	Pyruvate kinase; Belongs to the pyruvate kinase family.	Uncharacterized protein.	0.900