Groups of genes that are frequently observed in each other's genomic neighborhood.
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Experiments
Co-purification, co-crystallization, Yeast2Hybrid, Genetic Interactions, etc ... as imported from primary sources.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100694653
Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
il10
Interleukin 10. (275 aa)
LOC100707066
Interleukin-1. (244 aa)
LOC100534578
Tumor necrosis factor b (TNF superfamily, member 2). (247 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128 Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica