(52 nodes) SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain network (Oreochromis niloticus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	kmt5a	Lysine methyltransferase 5Aa. (333 aa)
	LOC100692734	Nuclear receptor binding SET domain protein 1a. (2550 aa)
	setd5	SET domain containing 5. (1521 aa)
	I3IU26_ORENI	Lysine (K)-specific methyltransferase 2E. (1590 aa)
	prdm13	PR domain containing 13. (636 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (768 aa)
	kmt2b	Lysine (K)-specific methyltransferase 2Bb. (3861 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2602 aa)
	prdm2	PR domain containing 2, with ZNF domain b. (1721 aa)
	LOC100699103	MDS1 and EVI1 complex locus. (1252 aa)
	smyd4	SET and MYND domain containing 4. (725 aa)
	KMT2A	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (4124 aa)
	setdb1	SET domain bifurcated histone lysine methyltransferase 1b. (1230 aa)
	prdm1	PR domain containing 1a, with ZNF domain. (848 aa)
	LOC100709898	Uncharacterized protein. (904 aa)
	creg1	Uncharacterized protein. (644 aa)
	I3JTS7_ORENI	Lysine (K)-specific methyltransferase 2Cb. (417 aa)
	setd7	SET domain containing 7, histone lysine methyltransferase. (361 aa)
	suv39h1	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (411 aa)
	kmt2d	Lysine (K)-specific methyltransferase 2D. (5041 aa)
	ENSONIP00000016295	Histone-lysine N-methyltransferase NSD2 isoform X2. (2144 aa)
	LOC100693266	Uncharacterized protein. (440 aa)
	ehmt2	Euchromatic histone-lysine N-methyltransferase 2. (1208 aa)
	PRDM6	PR/SET domain 6. (657 aa)
	LOC100692647	SET domain containing 1B, histone lysine methyltransferase a. (1811 aa)
	prdm8	PR domain containing 8b. (568 aa)
	prdm14	PR domain containing 14. (601 aa)
	prdm12	PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (389 aa)
	LOC100691614	Lysine methyltransferase 5C. (2039 aa)
	I3IW51_ORENI	SET domain-containing protein. (379 aa)
	LOC100708974	SET and MYND domain containing 1b. (535 aa)
	SMYD1	SET and MYND domain containing 1. (493 aa)
	Prdm11	PR domain-containing protein 11. (1081 aa)
	smyd5	SMYD family member 5. (427 aa)
	prdm5	Zinc finger protein. (630 aa)
	ENSONIP00000058389	[histone H4]-lysine20 N-methyltransferase SETD8. (248 aa)
	I3K397_ORENI	Nuclear receptor binding SET domain protein 2. (1109 aa)
	ehmt1	Euchromatic histone-lysine N-methyltransferase 1b. (1325 aa)
	I3JNL0_ORENI	Uncharacterized protein. (842 aa)
	setd1a	[histone H3]-lysine4 N-trimethyltransferase SETD1. (2262 aa)
	ENSONIP00000042957	Uncharacterized protein LOC109194549. (997 aa)
	LOC102078622	Uncharacterized protein LOC102078622 isoform X1. (1147 aa)
	I3KAI1_ORENI	Nuclear receptor binding SET domain protein 3. (1446 aa)
	LOC109194164	Uncharacterized protein. (784 aa)
	Kmt5b	Lysine methyltransferase 5B. (865 aa)
	LOC100698697	SET and MYND domain containing 2a. (435 aa)
	smyd3	SET and MYND domain containing 3. (439 aa)
	ezh2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (763 aa)
	LOC100707110	Ash1 (absent, small, or homeotic)-like (Drosophila). (2966 aa)
	LOC100689867	Histone-lysine N-methyltransferase 2B. (3138 aa)
	LOC100698471	SET domain and mariner transposase fusion gene. (317 aa)
	setd6	N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily. (460 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSONIP00000016295	I3IU26_ORENI	ENSONIP00000016295	ENSONIP00000000116	Histone-lysine N-methyltransferase NSD2 isoform X2.	Lysine (K)-specific methyltransferase 2E.	0.405
ENSONIP00000016295	setd2	ENSONIP00000016295	ENSONIP00000003855	Histone-lysine N-methyltransferase NSD2 isoform X2.	SET domain containing 2, histone lysine methyltransferase.	0.504
ENSONIP00000016295	setd7	ENSONIP00000016295	ENSONIP00000014561	Histone-lysine N-methyltransferase NSD2 isoform X2.	SET domain containing 7, histone lysine methyltransferase.	0.465
ENSONIP00000058389	Kmt5b	ENSONIP00000058389	ENSONIP00000018953	[histone H4]-lysine20 N-methyltransferase SETD8.	Lysine methyltransferase 5B.	0.420
ENSONIP00000058389	LOC100691614	ENSONIP00000058389	ENSONIP00000074042	[histone H4]-lysine20 N-methyltransferase SETD8.	Lysine methyltransferase 5C.	0.420
ENSONIP00000058389	setd7	ENSONIP00000058389	ENSONIP00000014561	[histone H4]-lysine20 N-methyltransferase SETD8.	SET domain containing 7, histone lysine methyltransferase.	0.444
EZH1	LOC100699103	ENSONIP00000001530	ENSONIP00000007027	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	MDS1 and EVI1 complex locus.	0.577
EZH1	suv39h1	ENSONIP00000001530	ENSONIP00000014663	Enhancer of zeste 1 polycomb repressive complex 2 subunit.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.495
I3IU26_ORENI	ENSONIP00000016295	ENSONIP00000000116	ENSONIP00000016295	Lysine (K)-specific methyltransferase 2E.	Histone-lysine N-methyltransferase NSD2 isoform X2.	0.405
I3IU26_ORENI	I3JNL0_ORENI	ENSONIP00000000116	ENSONIP00000055065	Lysine (K)-specific methyltransferase 2E.	Uncharacterized protein.	0.455
I3IU26_ORENI	I3JTS7_ORENI	ENSONIP00000000116	ENSONIP00000012272	Lysine (K)-specific methyltransferase 2E.	Lysine (K)-specific methyltransferase 2Cb.	0.510
I3IU26_ORENI	I3K397_ORENI	ENSONIP00000000116	ENSONIP00000058247	Lysine (K)-specific methyltransferase 2E.	Nuclear receptor binding SET domain protein 2.	0.405
I3IU26_ORENI	I3KAI1_ORENI	ENSONIP00000000116	ENSONIP00000018125	Lysine (K)-specific methyltransferase 2E.	Nuclear receptor binding SET domain protein 3.	0.536
I3IU26_ORENI	KMT2A	ENSONIP00000000116	ENSONIP00000007849	Lysine (K)-specific methyltransferase 2E.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.	0.465
I3IU26_ORENI	LOC100689867	ENSONIP00000000116	ENSONIP00000024873	Lysine (K)-specific methyltransferase 2E.	Histone-lysine N-methyltransferase 2B.	0.465
I3IU26_ORENI	LOC100692647	ENSONIP00000000116	ENSONIP00000017473	Lysine (K)-specific methyltransferase 2E.	SET domain containing 1B, histone lysine methyltransferase a.	0.703
I3IU26_ORENI	LOC100692734	ENSONIP00000000116	ENSONIP00000036851	Lysine (K)-specific methyltransferase 2E.	Nuclear receptor binding SET domain protein 1a.	0.405
I3IU26_ORENI	LOC100693266	ENSONIP00000000116	ENSONIP00000016993	Lysine (K)-specific methyltransferase 2E.	Uncharacterized protein.	0.495
I3IU26_ORENI	LOC100698471	ENSONIP00000000116	ENSONIP00000025548	Lysine (K)-specific methyltransferase 2E.	SET domain and mariner transposase fusion gene.	0.458
I3IU26_ORENI	LOC100698697	ENSONIP00000000116	ENSONIP00000021543	Lysine (K)-specific methyltransferase 2E.	SET and MYND domain containing 2a.	0.495