(30 nodes) Galactose metabolism network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	gla	Alpha-galactosidase. (430 aa)
	LOC100695517	Si:ch73-12o23.1; Belongs to the glycosyl hydrolase 31 family. (976 aa)
	Galk1	Galactokinase 1. (398 aa)
	gale	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (352 aa)
	efcab7	EF-hand calcium binding domain 7. (620 aa)
	G6PC2	Glucose-6-phosphatase catalytic subunit 2. (358 aa)
	pgm2	Phosphoglucomutase 2. (611 aa)
	LOC100708354	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (644 aa)
	b4galt2	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2. (382 aa)
	LOC100691259	Uncharacterized protein. (359 aa)
	LOC100710204	UTP--glucose-1-phosphate uridylyltransferase. (501 aa)
	glb1	Beta-galactosidase. (663 aa)
	LOC100534530	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
	g6pc	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (354 aa)
	I3KCF1_ORENI	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (777 aa)
	gck	Phosphotransferase. (478 aa)
	LOC100694159	Hexokinase 2. (937 aa)
	pfk	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (797 aa)
	galt	Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. (384 aa)
	g6pc3	Glucose-6-phosphatase 3. (339 aa)
	LOC100702997	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
	pfkl	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (799 aa)
	HK1	Hexokinase 1. (970 aa)
	gaa	Glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II); Belongs to the glycosyl hydrolase 31 family. (938 aa)
	LOC100692426	DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like. (479 aa)
	LOC100703330	Uncharacterized protein. (1893 aa)
	LOC100700843	Aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2. (324 aa)
	LOC100702375	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (794 aa)
	ugp2	UTP--glucose-1-phosphate uridylyltransferase. (517 aa)
	I3KQP7_ORENI	Uncharacterized protein. (598 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G6PC2	HK1	ENSONIP00000011110	ENSONIP00000046818	Glucose-6-phosphatase catalytic subunit 2.	Hexokinase 1.	0.953
G6PC2	I3KCF1_ORENI	ENSONIP00000011110	ENSONIP00000027936	Glucose-6-phosphatase catalytic subunit 2.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.511
G6PC2	I3KQP7_ORENI	ENSONIP00000011110	ENSONIP00000081332	Glucose-6-phosphatase catalytic subunit 2.	Uncharacterized protein.	0.911
G6PC2	LOC100534530	ENSONIP00000011110	ENSONIP00000023005	Glucose-6-phosphatase catalytic subunit 2.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.916
G6PC2	LOC100694159	ENSONIP00000011110	ENSONIP00000033188	Glucose-6-phosphatase catalytic subunit 2.	Hexokinase 2.	0.953
G6PC2	LOC100700843	ENSONIP00000011110	ENSONIP00000056473	Glucose-6-phosphatase catalytic subunit 2.	Aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 2.	0.802
G6PC2	LOC100702375	ENSONIP00000011110	ENSONIP00000070105	Glucose-6-phosphatase catalytic subunit 2.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.509
G6PC2	LOC100702997	ENSONIP00000011110	ENSONIP00000043892	Glucose-6-phosphatase catalytic subunit 2.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.507
G6PC2	LOC100703330	ENSONIP00000011110	ENSONIP00000055121	Glucose-6-phosphatase catalytic subunit 2.	Uncharacterized protein.	0.900
G6PC2	LOC100708354	ENSONIP00000011110	ENSONIP00000011338	Glucose-6-phosphatase catalytic subunit 2.	Galactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family.	0.900
G6PC2	efcab7	ENSONIP00000011110	ENSONIP00000011090	Glucose-6-phosphatase catalytic subunit 2.	EF-hand calcium binding domain 7.	0.911
G6PC2	g6pc	ENSONIP00000011110	ENSONIP00000023008	Glucose-6-phosphatase catalytic subunit 2.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.902
G6PC2	g6pc3	ENSONIP00000011110	ENSONIP00000042253	Glucose-6-phosphatase catalytic subunit 2.	Glucose-6-phosphatase 3.	0.904
G6PC2	gck	ENSONIP00000011110	ENSONIP00000030038	Glucose-6-phosphatase catalytic subunit 2.	Phosphotransferase.	0.953
G6PC2	glb1	ENSONIP00000011110	ENSONIP00000022152	Glucose-6-phosphatase catalytic subunit 2.	Beta-galactosidase.	0.900
G6PC2	pfk	ENSONIP00000011110	ENSONIP00000038521	Glucose-6-phosphatase catalytic subunit 2.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.510
G6PC2	pfkl	ENSONIP00000011110	ENSONIP00000045556	Glucose-6-phosphatase catalytic subunit 2.	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.	0.510
G6PC2	pgm2	ENSONIP00000011110	ENSONIP00000011259	Glucose-6-phosphatase catalytic subunit 2.	Phosphoglucomutase 2.	0.900
Galk1	I3KQP7_ORENI	ENSONIP00000010154	ENSONIP00000081332	Galactokinase 1.	Uncharacterized protein.	0.485
Galk1	LOC100710204	ENSONIP00000010154	ENSONIP00000020155	Galactokinase 1.	UTP--glucose-1-phosphate uridylyltransferase.	0.646