(49 nodes) Valine, leucine and isoleucine degradation network (Oreochromis niloticus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100706096	Aldedh domain-containing protein. (525 aa)
	mmut	Methylmalonyl CoA mutase. (798 aa)
	LOC100691671	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (329 aa)
	mcee	Methylmalonyl CoA epimerase. (173 aa)
	bckdha	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)
	hibch	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (382 aa)
	LOC100701752	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (533 aa)
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (715 aa)
	LOC100698670	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (489 aa)
	Echs1	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (401 aa)
	LOC100707807	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (367 aa)
	dld	Dihydrolipoyl dehydrogenase. (508 aa)
	LOC100700973	AU RNA binding protein/enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (328 aa)
	Acads	Acyl-CoA dehydrogenase short chain. (495 aa)
	aox1	Aldehyde oxidase 6. (1332 aa)
	abat	4-aminobutyrate aminotransferase. (564 aa)
	I3K9G5_ORENI	Amine oxidase. (529 aa)
	LOC100703044	Amine oxidase. (528 aa)
	aacs	Acetoacetyl-CoA synthetase. (676 aa)
	hadh	Uncharacterized protein. (309 aa)
	LOC100703463	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family. (518 aa)
	LOC100697026	Si:ch211-198n5.11. (619 aa)
	acat2	Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
	hsd17b10	Hydroxysteroid (17-beta) dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
	I3JQQ9_ORENI	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (375 aa)
	I3JTP3_ORENI	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (412 aa)
	acaa2	Acetyl-CoA acyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
	aldh16a1	Aldehyde dehydrogenase 16 family, member A1. (801 aa)
	LOC100704158	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a. (779 aa)
	LOC100712075	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (529 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (613 aa)
	ehhadh	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (719 aa)
	acat1	Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
	LOC100696541	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (329 aa)
	aldh2	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family. (589 aa)
	ivd	Isovaleryl-CoA dehydrogenase. (417 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (734 aa)
	LOC102078289	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (540 aa)
	acadsb	Acyl-CoA dehydrogenase short/branched chain. (453 aa)
	LOC100693723	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (498 aa)
	bckdhb	Branched chain keto acid dehydrogenase E1 subunit beta. (402 aa)
	pccb	Propionyl-CoA carboxylase subunit beta. (574 aa)
	LOC100697201	Amine oxidase. (546 aa)
	LOC100703423	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
	LOC100707943	Amine oxidase. (522 aa)
	ALDH6A1	Aldehyde dehydrogenase 6 family member A1. (519 aa)
	hmgcll1	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1. (356 aa)
	acadm	Acyl-CoA dehydrogenase medium chain. (436 aa)
	Acad8	Acyl-CoA dehydrogenase family, member 8. (396 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSF3	Acads	ENSONIP00000041028	ENSONIP00000014344	Acyl-CoA synthetase family member 3.	Acyl-CoA dehydrogenase short chain.	0.477
ACSF3	LOC100693723	ENSONIP00000041028	ENSONIP00000062318	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.927
ACSF3	LOC100698670	ENSONIP00000041028	ENSONIP00000010925	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.927
ACSF3	LOC100703423	ENSONIP00000041028	ENSONIP00000070131	Acyl-CoA synthetase family member 3.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.	0.409
ACSF3	LOC100703463	ENSONIP00000041028	ENSONIP00000023425	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase 9 family, member A1b; Belongs to the aldehyde dehydrogenase family.	0.932
ACSF3	LOC100704158	ENSONIP00000041028	ENSONIP00000037793	Acyl-CoA synthetase family member 3.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a.	0.409
ACSF3	LOC102078289	ENSONIP00000041028	ENSONIP00000054826	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.927
ACSF3	aacs	ENSONIP00000041028	ENSONIP00000021384	Acyl-CoA synthetase family member 3.	Acetoacetyl-CoA synthetase.	0.480
ACSF3	acadsb	ENSONIP00000041028	ENSONIP00000056126	Acyl-CoA synthetase family member 3.	Acyl-CoA dehydrogenase short/branched chain.	0.477
ACSF3	aldh16a1	ENSONIP00000041028	ENSONIP00000037445	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase 16 family, member A1.	0.932
ACSF3	aldh2	ENSONIP00000041028	ENSONIP00000050125	Acyl-CoA synthetase family member 3.	Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family.	0.932
ACSF3	aox1	ENSONIP00000041028	ENSONIP00000015395	Acyl-CoA synthetase family member 3.	Aldehyde oxidase 6.	0.920
ACSF3	ehhadh	ENSONIP00000041028	ENSONIP00000041857	Acyl-CoA synthetase family member 3.	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.494
ACSF3	hadh	ENSONIP00000041028	ENSONIP00000022073	Acyl-CoA synthetase family member 3.	Uncharacterized protein.	0.535
ACSF3	hibch	ENSONIP00000041028	ENSONIP00000009031	Acyl-CoA synthetase family member 3.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.437
ACSF3	mcee	ENSONIP00000041028	ENSONIP00000003752	Acyl-CoA synthetase family member 3.	Methylmalonyl CoA epimerase.	0.940
ACSF3	mmut	ENSONIP00000041028	ENSONIP00000001293	Acyl-CoA synthetase family member 3.	Methylmalonyl CoA mutase.	0.907
ALDH6A1	Acads	ENSONIP00000072252	ENSONIP00000014344	Aldehyde dehydrogenase 6 family member A1.	Acyl-CoA dehydrogenase short chain.	0.944
ALDH6A1	Echs1	ENSONIP00000072252	ENSONIP00000012057	Aldehyde dehydrogenase 6 family member A1.	Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.	0.510
ALDH6A1	LOC100691671	ENSONIP00000072252	ENSONIP00000003703	Aldehyde dehydrogenase 6 family member A1.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.981