(43 nodes) Porphyrin and chlorophyll metabolism network (Oreochromis niloticus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	cpox	Coproporphyrinogen oxidase. (455 aa)
	LOC100534482	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (527 aa)
	LOC100705244	Heme oxygenase 2b. (309 aa)
	blvra	Biliverdin reductase A. (289 aa)
	Ppox	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (479 aa)
	LOC100692842	Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (267 aa)
	LOC100708292	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (648 aa)
	alas1	5-aminolevulinate synthase. (621 aa)
	LOC100700023	Heme oxygenase 2a. (320 aa)
	LOC100700287	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (281 aa)
	ENSONIP00000023642	UDP-glucuronosyltransferase 2C1. (380 aa)
	LOC100707235	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (535 aa)
	ENSONIP00000026434	UDP-glucuronosyltransferase 2A2. (566 aa)
	uros	Uroporphyrinogen-III synthase. (261 aa)
	LOC109204569	UDP-glucuronosyltransferase 2B31-like isoform X1. (526 aa)
	Fxn	Frataxin, mitochondrial. (122 aa)
	LOC100710567	Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. (271 aa)
	LOC112841656	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (616 aa)
	LOC100694776	UDP-glucuronosyltransferase 2C1 isoform X1. (547 aa)
	ENSONIP00000039960	UDP-glucuronosyltransferase 2C1-like isoform X2. (553 aa)
	ENSONIP00000041519	UDP-glucuronosyltransferase 2A2 isoform X3. (242 aa)
	ENSONIP00000041707	UDP-glucuronosyltransferase 2A2. (242 aa)
	ENSONIP00000042409	UDP-glucuronosyltransferase isoform X1. (528 aa)
	Mmab	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. (233 aa)
	fech	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (403 aa)
	urod	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (369 aa)
	ENSONIP00000051256	LOW QUALITY PROTEIN: uncharacterized protein LOC109201007. (530 aa)
	LOC100695060	Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family. (477 aa)
	LOC100699240	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family. (647 aa)
	LOC100706335	UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (530 aa)
	blvrb	Biliverdin reductase B. (220 aa)
	LOC100697245	5-aminolevulinate synthase. (591 aa)
	LOC100708305	Uncharacterized protein. (527 aa)
	LOC102077353	Uncharacterized protein. (526 aa)
	LOC100708034	Uncharacterized protein. (562 aa)
	LOC100702684	Ceruloplasmin; Belongs to the multicopper oxidase family. (1080 aa)
	LOC102077549	UDP-glucuronosyltransferase 2B17. (543 aa)
	LOC106098479	UDP-glucuronosyltransferase 2B31. (533 aa)
	LOC109204527	Uncharacterized protein. (531 aa)
	EARS2	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (543 aa)
	eprs1	Glutamyl-prolyl-tRNA synthetase. (1684 aa)
	hmbs	Hydroxymethylbilane synthase a. (360 aa)
	I3JST3_ORENI	Cytochrome c oxidase assembly homolog 15 (yeast). (407 aa)

Your Current Organism:

Oreochromis niloticus

NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EARS2	I3JST3_ORENI	ENSONIP00000078552	ENSONIP00000080308	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Cytochrome c oxidase assembly homolog 15 (yeast).	0.448
EARS2	Mmab	ENSONIP00000078552	ENSONIP00000045939	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Corrinoid adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family.	0.419
EARS2	Ppox	ENSONIP00000078552	ENSONIP00000010114	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.	0.480
EARS2	cpox	ENSONIP00000078552	ENSONIP00000002155	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Coproporphyrinogen oxidase.	0.576
EARS2	eprs1	ENSONIP00000078552	ENSONIP00000078992	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Glutamyl-prolyl-tRNA synthetase.	0.991
EARS2	fech	ENSONIP00000078552	ENSONIP00000049512	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.452
EARS2	hmbs	ENSONIP00000078552	ENSONIP00000079127	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Hydroxymethylbilane synthase a.	0.591
EARS2	urod	ENSONIP00000078552	ENSONIP00000050717	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.	0.447
EARS2	uros	ENSONIP00000078552	ENSONIP00000027332	Glutamyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.	Uroporphyrinogen-III synthase.	0.431
ENSONIP00000023642	LOC100699240	ENSONIP00000023642	ENSONIP00000053521	UDP-glucuronosyltransferase 2C1.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.667
ENSONIP00000023642	LOC100708292	ENSONIP00000023642	ENSONIP00000016134	UDP-glucuronosyltransferase 2C1.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.667
ENSONIP00000023642	blvra	ENSONIP00000023642	ENSONIP00000007975	UDP-glucuronosyltransferase 2C1.	Biliverdin reductase A.	0.666
ENSONIP00000023642	blvrb	ENSONIP00000023642	ENSONIP00000057637	UDP-glucuronosyltransferase 2C1.	Biliverdin reductase B.	0.650
ENSONIP00000026434	LOC100699240	ENSONIP00000026434	ENSONIP00000053521	UDP-glucuronosyltransferase 2A2.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.667
ENSONIP00000026434	LOC100708292	ENSONIP00000026434	ENSONIP00000016134	UDP-glucuronosyltransferase 2A2.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.667
ENSONIP00000026434	blvra	ENSONIP00000026434	ENSONIP00000007975	UDP-glucuronosyltransferase 2A2.	Biliverdin reductase A.	0.658
ENSONIP00000026434	blvrb	ENSONIP00000026434	ENSONIP00000057637	UDP-glucuronosyltransferase 2A2.	Biliverdin reductase B.	0.650
ENSONIP00000039960	LOC100699240	ENSONIP00000039960	ENSONIP00000053521	UDP-glucuronosyltransferase 2C1-like isoform X2.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.702
ENSONIP00000039960	LOC100708292	ENSONIP00000039960	ENSONIP00000016134	UDP-glucuronosyltransferase 2C1-like isoform X2.	Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.	0.702
ENSONIP00000039960	blvra	ENSONIP00000039960	ENSONIP00000007975	UDP-glucuronosyltransferase 2C1-like isoform X2.	Biliverdin reductase A.	0.659