STRINGSTRING
GOT1 GOT1 pdhb pdhb LOC100706096 LOC100706096 mmut mmut pgls pgls LOC100704840 LOC100704840 mcee mcee LOC100692119 LOC100692119 hao1 hao1 glyctk glyctk I3J820_ORENI I3J820_ORENI h6pd h6pd glud1 glud1 ACSS1 ACSS1 hibch hibch sdha sdha I3JKS7_ORENI I3JKS7_ORENI psph psph pdha1 pdha1 eno4 eno4 Echs1 Echs1 LOC100707770 LOC100707770 SDS SDS dld dld LOC100705870 LOC100705870 Acads Acads idh3g idh3g rpia rpia LOC100703707 LOC100703707 gpt gpt acss2 acss2 hao2 hao2 LOC100692108 LOC100692108 pgk1 pgk1 prps1 prps1 I3KPD3_ORENI I3KPD3_ORENI got1 got1 LOC100692737 LOC100692737 LOC102082087 LOC102082087 LOC100710799 LOC100710799 pgp pgp ald ald I3KWE4_ORENI I3KWE4_ORENI mdh2 mdh2 fh fh I3KCF1_ORENI I3KCF1_ORENI acat2 acat2 LOC109194175 LOC109194175 LOC100702337 LOC100702337 gck gck Idh1 Idh1 LOC100690586 LOC100690586 aco2 aco2 me1 me1 I3KIC5_ORENI I3KIC5_ORENI LOC100691863 LOC100691863 LOC100694159 LOC100694159 LOC100704344 LOC100704344 TKT TKT psat1 psat1 idh3b idh3b LOC100704158 LOC100704158 LOC100697261 LOC100697261 pfk pfk PC PC LOC100690242 LOC100690242 me2 me2 ENSONIP00000041052 ENSONIP00000041052 LOC100711978 LOC100711978 LOC100534543 LOC100534543 LOC100699677 LOC100699677 LOC100705311 LOC100705311 ehhadh ehhadh LOC100702997 LOC100702997 LOC100703946 LOC100703946 acat1 acat1 LOC100709338 LOC100709338 DLST DLST pfkl pfkl HK1 HK1 LOC100695852 LOC100695852 ENSONIP00000047436 ENSONIP00000047436 LOC100707874 LOC100707874 acox3 acox3 LOC100694503 LOC100694503 Amt Amt LOC100712084 LOC100712084 pcca pcca adpgk adpgk Ogdhl Ogdhl idnk idnk LOC100712210 LOC100712210 sdhc sdhc TK TK esd esd LOC100696823 LOC100696823 pgam1 pgam1 LOC100695998 LOC100695998 taldo1 taldo1 suclg2 suclg2 cs cs I3JTA4_ORENI I3JTA4_ORENI LOC100699774 LOC100699774 I3JH18_ORENI I3JH18_ORENI tpi tpi pccb pccb eno1 eno1 G6pdh G6pdh I3K606_ORENI I3K606_ORENI OGDH OGDH LOC100696295 LOC100696295 LOC100702375 LOC100702375 LOC100703423 LOC100703423 LOC100706008 LOC100706008 tkfc tkfc pkm pkm LOC100702682 LOC100702682 LOC100705758 LOC100705758 sucla2 sucla2 SHMT2 SHMT2 ALDH6A1 ALDH6A1 LOC100695823 LOC100695823 me3 me3 rgn rgn LOC100711262 LOC100711262 LOC100691871 LOC100691871 gldc gldc Shmt1 Shmt1 suclg1 suclg1 LOC100707972 LOC100707972 SDHB SDHB cps1 cps1 LOC100696029 LOC100696029 LOC100712533 LOC100712533
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
GOT1Aspartate aminotransferase. (410 aa)
pdhbPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (360 aa)
LOC100706096Aldedh domain-containing protein. (525 aa)
mmutMethylmalonyl CoA mutase. (798 aa)
pgls6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (253 aa)
LOC100704840Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
mceeMethylmalonyl CoA epimerase. (173 aa)
LOC100692119Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (367 aa)
hao1Hydroxyacid oxidase (glycolate oxidase) 1. (371 aa)
glyctkGlycerate kinase. (524 aa)
I3J820_ORENIPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (264 aa)
h6pdHexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
glud1Glutamate dehydrogenase 1a; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (548 aa)
ACSS1Acetyl-coenzyme A synthetase. (688 aa)
hibch3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (382 aa)
sdhaSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (663 aa)
I3JKS7_ORENIPALP domain-containing protein. (523 aa)
psphPhosphoserine phosphatase. (227 aa)
pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (393 aa)
eno4Enolase 4. (568 aa)
Echs1Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family. (401 aa)
LOC100707770Serine--pyruvate aminotransferase. (430 aa)
SDSSerine dehydratase. (329 aa)
dldDihydrolipoyl dehydrogenase. (508 aa)
LOC100705870Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (339 aa)
AcadsAcyl-CoA dehydrogenase short chain. (495 aa)
idh3gIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
rpiaRibose 5-phosphate isomerase A (ribose 5-phosphate epimerase). (287 aa)
LOC100703707Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family. (709 aa)
gptSi:ch211-217a12.1. (994 aa)
acss2Acyl-CoA synthetase short chain family member 2. (698 aa)
hao2Hydroxyacid oxidase 2 (long chain). (356 aa)
LOC100692108Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (228 aa)
pgk1Phosphoglycerate kinase. (417 aa)
prps1Phosphoribosyl pyrophosphate synthetase 1B. (386 aa)
I3KPD3_ORENIGlucose-6-phosphate isomerase; Belongs to the GPI family. (552 aa)
got1Aspartate aminotransferase. (414 aa)
LOC100692737Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
LOC102082087Aminotran_1_2 domain-containing protein. (468 aa)
LOC100710799Aminotran_1_2 domain-containing protein. (435 aa)
pgpPhosphoglycolate phosphatase; Belongs to the HAD-like hydrolase superfamily. (306 aa)
aldFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (363 aa)
I3KWE4_ORENIDihydrolipoamide S-succinyltransferase. (480 aa)
mdh2Malate dehydrogenase. (331 aa)
fhFumarate hydratase. (499 aa)
I3KCF1_ORENIATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (777 aa)
acat2Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
LOC109194175Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (164 aa)
LOC100702337Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (174 aa)
gckPhosphotransferase. (478 aa)
Idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (429 aa)
LOC100690586Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (501 aa)
aco2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (833 aa)
me1Malic enzyme. (588 aa)
I3KIC5_ORENIIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (436 aa)
LOC100691863Transketolase a. (649 aa)
LOC100694159Hexokinase 2. (937 aa)
LOC100704344Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (422 aa)
TKTTransketolase. (632 aa)
psat1Phosphoserine aminotransferase. (416 aa)
idh3bIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
LOC100704158Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha a. (779 aa)
LOC100697261Acetyl-coenzyme A synthetase. (684 aa)
pfkATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (797 aa)
PCPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1209 aa)
LOC100690242Glutamic pyruvate transaminase (alanine aminotransferase) 2, like. (560 aa)
me2Malic enzyme. (591 aa)
ENSONIP00000041052Succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial-like. (148 aa)
LOC100711978Malate dehydrogenase. (383 aa)
LOC100534543Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
LOC100699677Enolase 3, (beta, muscle). (464 aa)
LOC100705311Aspartate aminotransferase. (449 aa)
ehhadhEnoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (719 aa)
LOC100702997ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (784 aa)
LOC100703946Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (560 aa)
acat1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (420 aa)
LOC100709338Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (395 aa)
DLSTDihydrolipoamide S-succinyltransferase. (448 aa)
pfklATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (799 aa)
HK1Hexokinase 1. (970 aa)
LOC100695852Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (539 aa)
ENSONIP00000047436Ribose-phosphate pyrophosphokinase 2. (342 aa)
LOC100707874Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (456 aa)
acox3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (698 aa)
LOC100694503Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (419 aa)
AmtAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (415 aa)
LOC100712084Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (351 aa)
pccaPropionyl-CoA carboxylase subunit alpha. (734 aa)
adpgkADP-dependent glucokinase. (497 aa)
OgdhlOxoglutarate dehydrogenase like. (1019 aa)
idnkGluconokinase; Belongs to the gluconokinase GntK/GntV family. (189 aa)
LOC100712210Acetyl-coenzyme A synthetase. (685 aa)
sdhcSuccinate dehydrogenase cytochrome b560 subunit, mitochondrial. (191 aa)
TKTransketolase b. (625 aa)
esdS-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (318 aa)
LOC100696823Glyceraldehyde-3-phosphate dehydrogenase. (361 aa)
pgam1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (254 aa)
LOC100695998Serine--pyruvate aminotransferase. (422 aa)
taldo1Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (355 aa)
suclg2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (431 aa)
csCitrate synthase; Belongs to the citrate synthase family. (481 aa)
I3JTA4_ORENIAminotran_1_2 domain-containing protein. (490 aa)
LOC100699774ADP-dependent glucokinase 2. (493 aa)
I3JH18_ORENIPyruvate kinase; Belongs to the pyruvate kinase family. (575 aa)
tpiTriosephosphate isomerase. (247 aa)
pccbPropionyl-CoA carboxylase subunit beta. (574 aa)
eno1Enolase 1a, (alpha). (451 aa)
G6pdhGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (559 aa)
I3K606_ORENIFructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family. (405 aa)
OGDHOxoglutarate dehydrogenase. (1029 aa)
LOC100696295Enolase 2. (459 aa)
LOC100702375ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (794 aa)
LOC100703423Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family. (763 aa)
LOC100706008Zgc:77938. (385 aa)
tkfcTriokinase/FMN cyclase. (580 aa)
pkmPyruvate kinase; Belongs to the pyruvate kinase family. (596 aa)
LOC100702682Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (593 aa)
LOC100705758Serine dehydratase-like. (329 aa)
sucla2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (466 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (548 aa)
ALDH6A1Aldehyde dehydrogenase 6 family member A1. (519 aa)
LOC100695823S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (395 aa)
me3Malic enzyme. (628 aa)
rgnRegucalcin. (297 aa)
LOC100711262Malate dehydrogenase, cytoplasmic isoform X2. (364 aa)
LOC100691871Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (394 aa)
gldcGlycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1030 aa)
Shmt1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (561 aa)
suclg1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (360 aa)
LOC100707972Glutamate dehydrogenase 1b; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (542 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (282 aa)
cps1Carbamoyl-phosphate synthase 1, mitochondrial. (1506 aa)
LOC100696029Triosephosphate isomerase. (248 aa)
LOC100712533Glycine cleavage system H protein, mitochondrial. (170 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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