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I3ITT5_ORENI I3ITT5_ORENI gar1 gar1 Mdn1 Mdn1 rexo2 rexo2 tbl3 tbl3 Lsg1 Lsg1 utp4 utp4 LOC100706520 LOC100706520 fbl fbl rrp7a rrp7a utp18 utp18 imp4 imp4 csnk2a2 csnk2a2 pop5 pop5 Fcf1 Fcf1 wdr36 wdr36 emg1 emg1 nvl nvl nop58 nop58 riok2 riok2 dkc1 dkc1 utp15 utp15 wdr3 wdr3 gnl2 gnl2 pop1 pop1 wdr75 wdr75 gtpbp4 gtpbp4 utp6 utp6 eif6 eif6 Xrn2 Xrn2 rpp30 rpp30 gnl3 gnl3 nop56 nop56 rpp38 rpp38 LOC100701316 LOC100701316 LOC109194537 LOC109194537 riok1 riok1 nmd3 nmd3 ran ran rcl1 rcl1 nob1 nob1 nat10 nat10 ak6 ak6 nxf1 nxf1 csnk2b csnk2b xrn1 xrn1 nol6 nol6 I3J3L9_ORENI I3J3L9_ORENI ENSONIP00000042235 ENSONIP00000042235 LOC100705890 LOC100705890 Pop4 Pop4 imp3 imp3 bms1 bms1 nop10 nop10 rexo1 rexo1 sbds sbds LOC100707405 LOC100707405 Rpp40 Rpp40 Snu13 Snu13 nxt2 nxt2 LOC100703095 LOC100703095 EFL1 EFL1 rbm28 rbm28 SPATA5 SPATA5 nhp2 nhp2 gnl3l gnl3l wdr43 wdr43 LOC100710852 LOC100710852 LOC100690588 LOC100690588 mphosph10 mphosph10 LOC100534434 LOC100534434
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I3ITT5_ORENIExportin 1 (CRM1 homolog, yeast) a. (1075 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (242 aa)
Mdn1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5480 aa)
rexo2Small fragment nuclease. (267 aa)
tbl3Transducin (beta)-like 3. (930 aa)
Lsg1Large 60S subunit nuclear export GTPase 1. (642 aa)
utp4UTP4 small subunit processome component. (690 aa)
LOC100706520PWP2 small subunit processome component. (921 aa)
fblFibrillarin. (320 aa)
rrp7aRibosomal RNA processing 7 homolog A. (282 aa)
utp18WD_REPEATS_REGION domain-containing protein. (531 aa)
imp4IMP U3 small nucleolar ribonucleoprotein 4. (307 aa)
csnk2a2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (355 aa)
pop5Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (168 aa)
Fcf1FCF1 rRNA-processing protein. (198 aa)
wdr36WD repeat domain 36. (886 aa)
emg1EMG1 N1-specific pseudouridine methyltransferase. (237 aa)
nvlNuclear VCP like. (847 aa)
nop58NOP58 ribonucleoprotein homolog (yeast). (537 aa)
riok2RIO kinase 2 (yeast). (524 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (501 aa)
utp15UTP15 small subunit processome component. (531 aa)
wdr3WD repeat domain 3. (941 aa)
gnl2Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (732 aa)
pop1POP1 homolog, ribonuclease P/MRP subunit. (982 aa)
wdr75WD repeat domain 75. (834 aa)
gtpbp4Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (635 aa)
utp6UTP6 small subunit processome component. (595 aa)
eif6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (246 aa)
Xrn25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (922 aa)
rpp30Ribonuclease P/MRP 30 subunit. (301 aa)
gnl3Guanine nucleotide binding protein-like 3 (nucleolar). (556 aa)
nop56NOP56 ribonucleoprotein homolog. (571 aa)
rpp38Ribonuclease P/MRP 38 subunit. (263 aa)
LOC100701316UTP14C small subunit processome component. (748 aa)
LOC109194537Ribonuclease P/MRP 25 subunit-like. (221 aa)
riok1Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (606 aa)
nmd360S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (505 aa)
ranGTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (260 aa)
rcl1RNA terminal phosphate cyclase-like 1. (376 aa)
nob1RNA-binding protein NOB1; May play a role in mRNA degradation. Belongs to the NOB1 family. (483 aa)
nat10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1055 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (176 aa)
nxf1Zgc:153681. (659 aa)
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (233 aa)
xrn15'-3' exoribonuclease 1. (1707 aa)
nol6Nucleolar protein 6. (1182 aa)
I3J3L9_ORENIRibonuclease P and MRP subunit p25, b. (235 aa)
ENSONIP00000042235Ribonuclease P protein subunit p25-like protein. (180 aa)
LOC100705890Exonuclease domain-containing protein. (1164 aa)
Pop4Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (211 aa)
imp3IMP U3 small nucleolar ribonucleoprotein 3. (183 aa)
bms1BMS1 ribosome biogenesis factor. (1209 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
rexo1REX1, RNA exonuclease 1 homolog. (1259 aa)
sbdsSBDS ribosome maturation factor. (253 aa)
LOC100707405Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. (151 aa)
Rpp40Ribonuclease P/MRP 40 subunit. (339 aa)
Snu13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (221 aa)
nxt2Nuclear transport factor 2-like export factor 2. (143 aa)
LOC100703095Exportin 1 (CRM1 homolog, yeast) b. (1083 aa)
EFL1Elongation factor like GTPase 1. (1098 aa)
rbm28RNA binding motif protein 28. (772 aa)
SPATA5Spermatogenesis associated 5. (900 aa)
nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (154 aa)
gnl3lGuanine nucleotide-binding protein-like 3-like protein isoform X2. (566 aa)
wdr43WD repeat domain 43. (654 aa)
LOC100710852Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (393 aa)
LOC100690588Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (445 aa)
mphosph10U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family. (701 aa)
LOC100534434Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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