STRINGSTRING
LOC100695712 LOC100695712 ippk ippk plcd3 plcd3 PLCB1 PLCB1 LOC100689896 LOC100689896 LOC100691684 LOC100691684 pik3cd pik3cd pip4p2 pip4p2 LOC100706013 LOC100706013 pi4k2b pi4k2b LOC100705971 LOC100705971 LOC100707403 LOC100707403 ip6k1 ip6k1 calml4 calml4 plcd1 plcd1 LOC100710349 LOC100710349 LOC100696589 LOC100696589 dgkb dgkb LOC100708735 LOC100708735 cdipt cdipt LOC100693657 LOC100693657 LOC100701793 LOC100701793 PIK3CA PIK3CA inpp5e inpp5e Plcg2 Plcg2 PLCB2 PLCB2 I3K4E0_ORENI I3K4E0_ORENI plcb3 plcb3 pikfyve pikfyve LOC100712427 LOC100712427 pi4ka pi4ka pik3c2a pik3c2a LOC100707864 LOC100707864 inpp5b inpp5b impad1 impad1 LOC100709397 LOC100709397 inppl1 inppl1 DGKD DGKD inpp4b inpp4b plcg1 plcg1 pi4k2a pi4k2a LOC100707861 LOC100707861 inpp1 inpp1 LOC100711065 LOC100711065 PIP5K1A PIP5K1A mtmr3 mtmr3 LOC100699493 LOC100699493 mtmr2 mtmr2 inpp5f inpp5f LOC100698523 LOC100698523 I3JCX9_ORENI I3JCX9_ORENI LOC100696879 LOC100696879 I3J790_ORENI I3J790_ORENI plce1 plce1 LOC100692694 LOC100692694 LOC100698894 LOC100698894 mtmr6 mtmr6 LOC100691250 LOC100691250 LOC100701963 LOC100701963 Prkca Prkca DGKQ DGKQ pih1d3 pih1d3 I3JK88_ORENI I3JK88_ORENI LOC100695545 LOC100695545 ocrl ocrl dgkz dgkz Itpr3 Itpr3 PRKCB PRKCB mtmr14 mtmr14 I3KQM2_ORENI I3KQM2_ORENI LOC100690473 LOC100690473 LOC100703205 LOC100703205 ppip5k1 ppip5k1 LOC100704479 LOC100704479 LOC100701476 LOC100701476 itpka itpka Pip5k1c Pip5k1c LOC100691757 LOC100691757 Pik3cb Pik3cb pik3c3 pik3c3 calm1 calm1 itpk1 itpk1 LOC100710015 LOC100710015 Mtm1 Mtm1 dgke dgke I3JZ86_ORENI I3JZ86_ORENI Pip4k2c Pip4k2c plcd4 plcd4 LOC100704507 LOC100704507 synj1 synj1 PTEN PTEN mtmr7 mtmr7 pik3r1 pik3r1 MTMR4 MTMR4 I3JAQ2_ORENI I3JAQ2_ORENI LOC100712230 LOC100712230 LOC100698290 LOC100698290 I3KSK9_ORENI I3KSK9_ORENI PIP4K2B PIP4K2B LOC100705399 LOC100705399 LOC100691170 LOC100691170 LOC100695224 LOC100695224
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC100695712Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (464 aa)
ippkInositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (503 aa)
plcd3Phosphoinositide phospholipase C. (791 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1239 aa)
LOC1006898961-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1161 aa)
LOC100691684Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (834 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
pip4p2Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
LOC100706013Inositol polyphosphate phosphatase-like 1b. (1219 aa)
pi4k2bPhosphatidylinositol 4-kinase type 2 beta. (510 aa)
LOC100705971Kinase; Belongs to the inositol phosphokinase (IPK) family. (688 aa)
LOC100707403Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (936 aa)
ip6k1Kinase; Belongs to the inositol phosphokinase (IPK) family. (524 aa)
calml4Calmodulin-like 4a. (153 aa)
plcd1Phosphoinositide phospholipase C. (784 aa)
LOC100710349Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (263 aa)
LOC100696589Inositol-1-monophosphatase. (283 aa)
dgkbDiacylglycerol kinase. (783 aa)
LOC100708735Diacylglycerol kinase. (1233 aa)
cdiptCDP-diacylglycerol--inositol 3-phosphatidyltransferase. (212 aa)
LOC100693657Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (735 aa)
LOC100701793Calmodulin-like 4b. (153 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1070 aa)
inpp5eInositol polyphosphate-5-phosphatase E. (641 aa)
Plcg21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1270 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1267 aa)
I3K4E0_ORENIUncharacterized protein. (469 aa)
plcb31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1261 aa)
pikfyvePhosphoinositide kinase, FYVE finger containing. (2087 aa)
LOC100712427Inositol-1-monophosphatase. (282 aa)
pi4kaPhosphatidylinositol 4-kinase, catalytic, alpha b; Belongs to the PI3/PI4-kinase family. (2135 aa)
pik3c2aPhosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1726 aa)
LOC100707864Phosphatidylinositol-4-phosphate 5-kinase, type I, beta b. (554 aa)
inpp5bInositol polyphosphate-5-phosphatase B. (905 aa)
impad1Inositol monophosphatase domain containing 1. (353 aa)
LOC100709397Diacylglycerol kinase. (747 aa)
inppl1Inositol polyphosphate phosphatase-like 1a. (1248 aa)
DGKDDiacylglycerol kinase. (1206 aa)
inpp4bInositol polyphosphate-4-phosphatase type II B. (958 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1311 aa)
pi4k2aPhosphatidylinositol 4-kinase type 2 alpha. (447 aa)
LOC100707861Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
inpp1Si:ch211-160o17.2. (377 aa)
LOC1007110651-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1294 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (577 aa)
mtmr3Myotubularin related protein 3. (1228 aa)
LOC100699493Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (992 aa)
mtmr2Myotubularin related protein 2. (659 aa)
inpp5fInositol polyphosphate-5-phosphatase F. (1133 aa)
LOC100698523Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa)
I3JCX9_ORENIKinase; Belongs to the inositol phosphokinase (IPK) family. (317 aa)
LOC100696879Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (434 aa)
I3J790_ORENIDiacylglycerol kinase. (1298 aa)
plce1Phospholipase C, epsilon 1. (2342 aa)
LOC100692694Inositol 1,4,5-trisphosphate receptor, type 1b. (2781 aa)
LOC100698894Diacylglycerol kinase. (899 aa)
mtmr6Myotubularin related protein 6. (663 aa)
LOC100691250Diacylglycerol kinase. (767 aa)
LOC100701963Myotubularin related protein 1a. (693 aa)
PrkcaProtein kinase C, alpha, a. (674 aa)
DGKQDiacylglycerol kinase. (974 aa)
pih1d3Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (326 aa)
I3JK88_ORENIPhosphoinositide phospholipase C. (774 aa)
LOC100695545Kinase; Belongs to the inositol phosphokinase (IPK) family. (459 aa)
ocrlOCRL inositol polyphosphate-5-phosphatase. (977 aa)
dgkzDiacylglycerol kinase. (1313 aa)
Itpr3Inositol 1,4,5-trisphosphate receptor, type 3. (2638 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
mtmr14Myotubularin related protein 14. (700 aa)
I3KQM2_ORENIPhosphoinositide-3-kinase, regulatory subunit 3a (gamma). (521 aa)
LOC100690473Phosphatidylinositol 3-kinase regulatory subunit gamma b. (698 aa)
LOC100703205Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (842 aa)
ppip5k1Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1445 aa)
LOC100704479Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1072 aa)
LOC100701476Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b. (610 aa)
itpkaKinase; Belongs to the inositol phosphokinase (IPK) family. (457 aa)
Pip5k1cPhosphatidylinositol-4-phosphate 5-kinase, type I, gamma a. (648 aa)
LOC100691757Phosphoinositide phospholipase C. (774 aa)
Pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1085 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (884 aa)
calm1Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
itpk1Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (389 aa)
LOC100710015Uncharacterized protein. (718 aa)
Mtm1Myotubularin 1. (614 aa)
dgkeDiacylglycerol kinase. (576 aa)
I3JZ86_ORENIPhosphatidylinositol 4-kinase, catalytic, alpha a; Belongs to the PI3/PI4-kinase family. (2085 aa)
Pip4k2cPhosphatidylinositol-5-phosphate 4-kinase, type II, gamma a. (473 aa)
plcd4Phosphoinositide phospholipase C. (780 aa)
LOC100704507Kinase; Belongs to the inositol phosphokinase (IPK) family. (500 aa)
synj1Synaptojanin 1. (1683 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (536 aa)
mtmr7Myotubularin related protein 7a. (649 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (729 aa)
MTMR4Myotubularin related protein 4. (1246 aa)
I3JAQ2_ORENISAC1 like phosphatidylinositide phosphatase a. (616 aa)
LOC100712230Myotubularin related protein 7b. (577 aa)
LOC100698290Phosphatidylinositol-4-phosphate 5-kinase, type I, beta a. (510 aa)
I3KSK9_ORENIInositol 1,4,5-trisphosphate receptor, type 1a. (2718 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (443 aa)
LOC100705399Phosphatidylinositol-5-phosphate 4-kinase, type II, gamma b. (442 aa)
LOC100691170Kinase; Belongs to the inositol phosphokinase (IPK) family. (765 aa)
LOC100695224Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. (471 aa)
Your Current Organism:
Oreochromis niloticus
NCBI taxonomy Id: 8128
Other names: Nile tilapia, O. niloticus, Oreochromis nilotica, Tilapia nilotica
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